Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TRPS1 (from a repository: Fri Jan 13 03:55:43 2017)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)18
The number (and %) of the onco-proteins5 (27.78 %)
The number (and %) of the tumor suppressors3 (16.67 %)
Total number of binary PPIs (saturation %)41 (26.80 %)
The number (and %) of affected PPIs17 (41.46 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI3.444
Assortativity coefficient-0.4823
The network average Clustering coefficient0.567
The number (and %) of a zero Clustering coefficients5 (27.78 %)
The number (and %) of a zero Betweenness Centrality13 (72.22 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TRPS1 All fusions
Proteins found in more fusions CTBP1 (see 2 fusions); NLK (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TRPS1parental protein170.103220.667Rubredoxin (PF00301, IPR024935): Rubredoxin
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_7 (PF15269): Zinc-finger
2 CDK18oncoprotein100APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
3 CDK2AP1suppressor21.0000CDK2AP (PF09806, IPR019187): Cyclin-dependent kinase 2-associated protein
4 CEP170P1interactor200NA
5 CTBP1protein found in more fusions41.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
6 DYNLL1interactor31.0000Dynein_light (PF01221, IPR001372): Dynein light chain type 1
7 FOXJ2interactor100SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
Spt20 (PF12090, IPR021950): Spt20 family
Pro-rich (PF15240, IPR026086): Proline-rich
8 HDAC1suppressor60.6003.667FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
9 MAPK3oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
10 MCM6interactor31.0000MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
YmgB (PF10798, IPR024753): Biofilm development protein YmgB/AriR
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
11 NFATC1oncoprotein40.6672.000RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
12 NLKprotein found in more fusions200Pkinase (PF00069, IPR000719): Protein kinase domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
13 RNF4interactor41.0000Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
14 SEC16Ainteractor100APC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
15 SUMO1interactor41.0000Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
16 TEAD2interactor21.0000TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
17 TP53BP1suppressor50.4006.00053-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
18 UBE2Iinteractor80.42911.667UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

B a c k    t o    T o p ⇑