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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RAP2A, TRPS1 (from a repository: Wed Jan 9 01:35:52 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)53
The number (and %) of the onco-proteins14 (26.42 %)
The number (and %) of the tumor suppressors7 (13.21 %)
Total number of binary PPIs (saturation %)122 (8.85 %)
The number (and %) of affected PPIs51 (41.80 %)
The number of possible different fusions9
PPI diameter5
PPI radius3
The average degree of PPI3.774
Assortativity coefficient-0.5897
The network average Clustering coefficient0.168
The number (and %) of a zero Clustering coefficients28 (52.83 %)
The number (and %) of a zero Betweenness Centrality24 (45.28 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TRPS1,RAP2A All fusions
Proteins found in more fusions FTL (see 3 fusions); CTBP1 (see 2 fusions); NLK (see 4 fusions); NEDD4 (see 1 fusions); RASSF5 (see 2 fusions); HDAC1 (see 1 fusions); MTOR (see 1 fusions); SGK1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TRPS1parental protein170.103509.854Rubredoxin (PF00301, IPR024935): Rubredoxin
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_7 (PF15269): Zinc-finger
2 RAP2Aparental protein340.0271829.781Ras (PF00071, IPR001806, SM00173): Ras family
3 ATMsuppressor50.16775.061FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
4 CCT6Ainteractor2038.386Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
5 CDK18oncoprotein100APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
6 CDK2AP1suppressor30.33315.533CDK2AP (PF09806, IPR019187): Cyclin-dependent kinase 2-associated protein
7 CEP170P1interactor200NA
8 CTBP1protein found in more fusions50.50019.8382-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
9 DDX39Ainteractor3022.106DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
10 DYNLL1interactor40.33324.400Dynein_light (PF01221, IPR001372): Dynein light chain type 1
11 EEF1A1suppressor50.33360.810GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
12 ELAVL1oncoprotein100.083321.528RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
13 ENSAinteractor100Endosulfine (PF04667, IPR006760): cAMP-regulated phosphoprotein/endosulfine conserved region
14 FKBP2interactor2033.317FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
15 FOXJ2interactor2014.066SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
Spt20 (PF12090, IPR021950): Spt20 family
Pro-rich (PF15240, IPR026086): Proline-rich
16 FTLprotein found in more fusions200Ferritin (PF00210, IPR008331): Ferritin-like domain
17 GABARAPL2interactor30.6672.100Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
18 HDAC1suppressor80.28667.895FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
19 MAPK3oncoprotein50.16766.333Pkinase (PF00069, IPR000719): Protein kinase domain
20 MCM6interactor31.0000MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
YmgB (PF10798, IPR024753): Biofilm development protein YmgB/AriR
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
21 MOV10interactor60.20068.997AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
22 MTORoncoprotein70.26797.156DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
TPR_19 (PF14559): Tetratricopeptide repeat
23 NEDD4suppressor60.30034.250Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
24 NFATC1oncoprotein40.6674.138RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
25 NLKprotein found in more fusions3014.066Pkinase (PF00069, IPR000719): Protein kinase domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
26 NSFinteractor200AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
ATPase (PF06745, IPR014774): KaiC
AAA_19 (PF13245): AAA domain
27 NXF1interactor80.190163.396NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
28 P2RY14oncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
Ni_hydr_CYTB (PF01292, IPR011577): Prokaryotic cytochrome b561
29 PHF19interactor200PHD (PF00628, IPR019787, SM00249): PHD-finger
Mtf2_C (PF14061, IPR025894): Polycomb-like MTF2 factor 2
DUF4537 (PF15057, IPR032770): Domain of unknown function (DUF4537)
30 PIFOinteractor100SHIPPO-rpt (PF07004, IPR010736): Sperm-tail PG-rich repeat
31 PLGinteractor100Kringle (PF00051, IPR000001): Kringle domain
PAN_1 (PF00024, IPR003014): PAN domain
Trypsin (PF00089, IPR001254, SM00020): Trypsin
32 RABGGTBoncoprotein100Prenyltrans (PF00432, IPR001330): Prenyltransferase and squalene oxidase repeat
33 RALGDSoncoprotein2033.317RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
34 RAPGEF3interactor100DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
BAT (PF15915, IPR031803): GAF and HTH_10 associated domain
35 RAPGEF4interactor100DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
36 RAPGEF5interactor100DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
37 RAPGEF6interactor50.4005.128PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
38 RASSF5suppressor200RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
39 RGS14interactor100GoLoco (PF02188, IPR003109, SM00390): GoLoco motif
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
RGS12_us1 (PF16613): Unstructured region of RGS12
40 RNF4interactor41.0000Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
41 RRP9oncoprotein100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
HPS3_N (PF14761, IPR029437): Hermansky-Pudlak syndrome 3
42 RUNDC3Ainteractor100Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20
RUN (PF02759, IPR004012, SM00593): RUN domain
43 SEC16Ainteractor100APC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
44 SERPINA1oncoprotein100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
45 SGK1oncoprotein50.5007.417Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
46 SHMT2interactor40.33336.215SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
47 SLC30A4interactor100Cation_efflux (PF01545, IPR002524): Cation efflux family
48 SUMO1interactor50.50049.684Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
49 TEAD2interactor70.048159.470TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
50 TM7SF2interactor100ERG4_ERG24 (PF01222, IPR001171): Ergosterol biosynthesis ERG4/ERG24 family
51 TMEM185Ainteractor100Tmemb_185A (PF10269, IPR019396): Transmembrane Fragile-X-F protein
52 TP53BP1suppressor90.139165.41653-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
53 UBE2Iinteractor90.35776.342UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

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