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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins HLA-DQA1, TRPS1 (from a repository: Thu Jul 25 10:29:12 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)48
The number (and %) of the onco-proteins10 (20.83 %)
The number (and %) of the tumor suppressors5 (10.42 %)
Total number of binary PPIs (saturation %)89 (7.89 %)
The number (and %) of affected PPIs46 (51.69 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI3.000
Assortativity coefficient-0.5681
The network average Clustering coefficient0.264
The number (and %) of a zero Clustering coefficients28 (58.33 %)
The number (and %) of a zero Betweenness Centrality32 (66.67 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HLA-DQA1,TRPS1 All fusions
Proteins found in more fusions CTBP1 (see 2 fusions); NLK (see 4 fusions); NR2F2 (see 1 fusions); SH3GL2 (see 1 fusions); CD74 (see 13 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HLA-DQA1parental protein290.0071610.771MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
2 TRPS1parental protein170.103472.790Rubredoxin (PF00301, IPR024935): Rubredoxin
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_7 (PF15269): Zinc-finger
3 APLP1interactor21.0000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
Ints3 (PF10189, IPR019333): Integrator complex subunit 3
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 ATP2B2interactor100Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
ATP_Ca_trans_C (PF12424, IPR022141): Plasma membrane calcium transporter ATPase C terminal
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
5 ATP6V0A1interactor100V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
6 ATP6V0A2interactor100V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
7 CD74oncoprotein200MHC2-interact (PF09307, IPR015386): CLIP, MHC2 interacting
MHCassoc_trimer (PF08831, IPR011988): Class II MHC-associated invariant chain trimerisation domain
Thyroglobulin_1 (PF00086, IPR000716, SM00211): Thyroglobulin type-1 repeat
8 CDK18oncoprotein100APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
9 CDK2AP1suppressor21.0000CDK2AP (PF09806, IPR019187): Cyclin-dependent kinase 2-associated protein
10 CDK7oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
11 CEP170P1interactor200NA
12 CTBP1protein found in more fusions41.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
13 CUX1suppressor50.100370.595Baculo_p24 (PF05073, IPR007765): Baculovirus P24 capsid protein
CUT (PF02376, IPR003350, SM01109): CUT domain
DegS (PF05384, IPR008595): Sensor protein DegS
DivIC (PF04977, IPR007060): Septum formation initiator
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Swi5 (PF07061, IPR010760): Swi5
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
ApoO (PF09769, IPR019166): Apolipoprotein O
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
RIC3 (PF15361, IPR032763): Resistance to inhibitors of cholinesterase homologue 3
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
14 DDX19Binteractor21.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
15 DYNLL1interactor31.0000Dynein_light (PF01221, IPR001372): Dynein light chain type 1
16 EFNB1interactor100Ephrin (PF00812, IPR001799): Ephrin
DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
TMEM132D_C (PF15706, IPR031436): Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
17 FOXJ2interactor2027.797SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
Spt20 (PF12090, IPR021950): Spt20 family
Pro-rich (PF15240, IPR026086): Proline-rich
18 GALTinteractor100GalP_UDP_tr_C (PF02744, IPR005850): Galactose-1-phosphate uridyl transferase, C-terminal domain
GalP_UDP_transf (PF01087, IPR005849): Galactose-1-phosphate uridyl transferase, N-terminal domain
19 HDAC1suppressor80.286171.578FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
20 HLA-Aoncoprotein100DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
21 IKBKGinteractor40.333107.808CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
22 KCNJ8interactor100IRK (PF01007, IPR016449): Inward rectifier potassium channel
23 LRIF1interactor31.0000LRIF1 (PF15741, IPR026191): Ligand-dependent nuclear receptor-interacting factor 1
24 MACO1interactor100Macoilin (PF09726, IPR019130): Transmembrane protein
25 MAPK3oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
26 MCM6interactor31.0000MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
YmgB (PF10798, IPR024753): Biofilm development protein YmgB/AriR
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
27 MFSD8interactor100MFS_1 (PF07690, IPR011701): Major Facilitator Superfamily
28 MYO19interactor2071.722IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
29 NFATC1oncoprotein50.40040.927RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
30 NLKprotein found in more fusions200Pkinase (PF00069, IPR000719): Protein kinase domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
31 NR2F2protein found in more fusions40153.567zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
32 RNF4interactor50.50085.975Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
33 SEC16Ainteractor2046.222APC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
34 SH3GL2oncoprotein200BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
35 SLC27A6interactor100AMP-binding (PF00501, IPR000873): AMP-binding enzyme
AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
36 SLC30A9interactor100Cation_efflux (PF01545, IPR002524): Cation efflux family
IncA (PF04156, IPR007285): IncA protein
XPA_C (PF05181, IPR022656): XPA protein C-terminus
RapA_C (PF12137, IPR022737): RNA polymerase recycling family C-terminal
37 SLC38A9interactor100Aa_trans (PF01490, IPR004758): Transmembrane amino acid transporter protein
38 SMPD2interactor100Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
39 ST7suppressor100ST7 (PF04184, IPR007311): ST7 protein
40 SUMO1interactor41.0000Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
41 TEAD2interactor30.33330.556TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
42 TLE1interactor3082.678TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
43 TMEM214interactor100TMEM214 (PF10151, IPR019308): TMEM214, C-terminal, caspase 4 activator
44 TMEM219interactor100TMEM219 (PF14940): Transmembrane 219
TMEM52 (PF14979): Transmembrane 52
45 TMEM246interactor100NA
46 TP53BP1suppressor60.267187.03853-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
47 UBE2Iinteractor90.321110.179UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
48 UNC119interactor20103.797GMP_PDE_delta (PF05351, IPR008015): GMP-PDE, delta subunit

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