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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FRMD4B, TMF1 (from a repository: Mon Aug 19 11:49:51 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins7 (43.75 %)
The number (and %) of the tumor suppressors1 (6.25 %)
Total number of binary PPIs (saturation %)23 (19.17 %)
The number (and %) of affected PPIs14 (60.87 %)
The number of possible different fusions5
PPI diameter4
PPI radius2
The average degree of PPI2.125
Assortativity coefficient-0.4294
The network average Clustering coefficient0.168
The number (and %) of a zero Clustering coefficients12 (75.00 %)
The number (and %) of a zero Betweenness Centrality12 (75.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TMF1,FRMD4B All fusions
Proteins found in more fusions ITSN2 (see 5 fusions); FER (see 1 fusions); NR3C1 (see 8 fusions); KAT2B (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TMF1parental protein130.026199.000Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
NHase_beta (PF02211, IPR024690): Nitrile hydratase beta subunit
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
PilW (PF16074, IPR032092): Type IV Pilus-assembly protein W
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
2 FRMD4Bparental protein100FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
Med30 (PF11315, IPR021019): Mediator complex subunit 30
DUF3338 (PF11819, IPR021774): Domain of unknown function (DUF3338)
3 AP1M2interactor100Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
4 ARoncoprotein40.6671.000Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
5 CCDC183interactor100MRP-63 (PF14978, IPR016576): Mitochondrial ribosome protein 63
6 FERprotein found in more fusions200DivIC (PF04977, IPR007060): Septum formation initiator
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
Glyco_transf_28 (PF03033, IPR004276): Glycosyltransferase family 28 N-terminal domain
PEP-utilisers_N (PF05524, IPR008731): PEP-utilising enzyme, N-terminal
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
Med29 (PF11568, IPR021018): Mediator complex subunit 29
7 FOXK2interactor2052.000FHA (PF00498, IPR000253, SM00240): FHA domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
8 GFI1Boncoprotein100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
9 ITSN2protein found in more fusions200C2 (PF00168, IPR000008, SM00239): C2 domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
VIR_N (PF15912, IPR031801): Virilizer, N-terminal
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
10 KAT2Bprotein found in more fusions31.0000Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
11 NR3C1protein found in more fusions200GCR (PF02155, IPR001409): Glucocorticoid receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
12 PLK1suppressor100Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
13 TCP10L2interactor100DUF4527 (PF15030, IPR032771): Protein of unknown function (DUF4527)
14 TMEM216interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
15 USP7oncoprotein31.0000MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
16 XPO1interactor2028.000CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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