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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TG, TYROBP (from a repository: Thu Dec 15 09:44:47 2016)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)11
The number (and %) of the onco-proteins1 (9.09 %)
The number (and %) of the tumor suppressors1 (9.09 %)
Total number of binary PPIs (saturation %)19 (34.55 %)
The number (and %) of affected PPIs10 (52.63 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI2.182
Assortativity coefficient-0.3516
The network average Clustering coefficient0.524
The number (and %) of a zero Clustering coefficients4 (36.36 %)
The number (and %) of a zero Betweenness Centrality9 (81.82 %)


List of the fusions

PPI for parental proteins: TG,TYROBP All fusions
Proteins found in more fusions SYK (see 1 fusions); TG (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 TGparental protein31.0000COesterase (PF00135, IPR002018): Carboxylesterase family
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Thyroglobulin_1 (PF00086, IPR000716, SM00211): Thyroglobulin type-1 repeat
PAN_4 (PF14295, IPR003609): PAN domain
2 TYROBPparental protein70.09537.000DAP10 (PF07213, IPR009861): DAP10 membrane protein
DUF4741 (PF15897, IPR031773): Domain of unknown function (DUF4741)
3 HSPA5oncoprotein31.0000HSP70 (PF00012, IPR013126): Hsp70 protein
4 KIR2DS2interactor200ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
5 KLRA1Pinteractor21.0000DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
6 NCR2interactor100V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
7 P4HBinteractor31.0000Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
8 SIRPB1interactor21.0000CD34_antigen (PF06365, IPR013836): CD34/Podocalyxin family
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
9 SYKsuppressor40.6671.000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
10 TREM1interactor200V-set (PF07686, IPR013106): Immunoglobulin V-set domain
11 ZAP70interactor200Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain

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