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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PCBP3, TAF4B (from a repository: Thu Dec 5 16:55:47 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)33
The number (and %) of the onco-proteins13 (39.39 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)73 (13.83 %)
The number (and %) of affected PPIs31 (42.47 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI3.636
Assortativity coefficient-0.6688
The network average Clustering coefficient0.418
The number (and %) of a zero Clustering coefficients13 (39.39 %)
The number (and %) of a zero Betweenness Centrality22 (66.67 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TAF4B,PCBP3 All fusions
Proteins found in more fusions PFKL (see 2 fusions); TAF8 (see 2 fusions); KPNB1 (see 2 fusions); PTBP1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TAF4Bparental protein100.37881.000TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family
TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
2 PCBP3parental protein210.033764.667KH_1 (PF00013, IPR004088, SM00322): KH domain
3 AKR1B10interactor100Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
4 BACH1interactor200BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
5 BBOX1interactor200DUF971 (PF06155, IPR010376): Protein of unknown function (DUF971)
TauD (PF02668, IPR003819): Taurine catabolism dioxygenase TauD, TfdA family
6 CEP128interactor21.0000DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
7 DCP2interactor21.0000DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain
NUDIX (PF00293, IPR000086): NUDIX domain
8 DLDinteractor100Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
9 FAM96Binteractor21.0000DUF59 (PF01883, IPR002744): Domain of unknown function DUF59
10 FTH1interactor31.0000Coat_F (PF07875, IPR012851): Coat F domain
Ferritin (PF00210, IPR008331): Ferritin-like domain
11 GTF2A1oncoprotein31.0000TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
12 HIST3H3interactor60.60067.300Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
13 KCTD17interactor200BTB_2 (PF02214, IPR003131): BTB/POZ domain
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
14 KPNB1protein found in more fusions50.33351.600Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
15 MED26interactor41.0000Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
Med26_C (PF15693, IPR031416): Mediator complex subunit 26 C-terminal
Med26_M (PF15694, IPR031417): Mediator complex subunit 26 middle domain
16 PCBP1oncoprotein50.50016.667Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
17 PCM1oncoprotein21.0000FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
RseA_C (PF03873, IPR005573): Anti sigma-E protein RseA, C-terminal domain
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
AAA_23 (PF13476): AAA domain
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
DUF4829 (PF16111, IPR032256): Domain of unknown function (DUF4829)
18 PDCD2Linteractor100PDCD2_C (PF04194, IPR007320): Programmed cell death protein 2, C-terminal putative domain
zf-RRN7 (PF11781, IPR021752): Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7
19 PFKLprotein found in more fusions200PFK (PF00365, IPR000023): Phosphofructokinase
20 PPP1R18interactor100Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124)
Phostensin (PF13914, IPR025907): Phostensin PP1-binding and SH3-binding region
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
21 PTBP1oncoprotein40.33386.133RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
22 PTBP2interactor200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
23 RBM39oncoprotein100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
24 RELAoncoprotein41.0000DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
25 RHODinteractor100Ras (PF00071, IPR001806, SM00173): Ras family
26 RUVBL1oncoprotein60.500167.100TIP49 (PF06068, IPR010339): TIP49 C-terminus
27 RUVBL2oncoprotein60.500167.100TIP49 (PF06068, IPR010339): TIP49 C-terminus
28 SPENoncoprotein100ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Rxt3 (PF08642, IPR013951): Histone deacetylation protein Rxt3
SPOC (PF07744, IPR012921): SPOC domain
DUF4692 (PF15763, IPR031517): Domain of unknown function (DUF4692)
29 TAF1oncoprotein70.6197.000Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
LcrG (PF07216, IPR009863): LcrG protein
Opi1 (PF08618, IPR013927): Transcription factor Opi1
Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal
TBP-binding (PF09247, IPR009067): TATA box-binding protein binding
U3_snoRNA_assoc (PF08297, IPR013268): U3 snoRNA associated
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
DUF3591 (PF12157, IPR022591): Protein of unknown function (DUF3591)
zf-CCHC_6 (PF15288): Zinc knuckle
30 TAF12interactor41.0000TFIID_20kDa (PF03847, IPR003228): Transcription initiation factor TFIID subunit A
31 TAF8protein found in more fusions80.6197.000Bromo_TP (PF07524, IPR006565): Bromodomain associated
TAF8_C (PF10406, IPR019473): Transcription factor TFIID complex subunit 8 C-term
DUF3090 (PF11290, IPR021441): Protein of unknown function (DUF3090)
32 TBPinteractor110.378250.433TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
33 TSTA3interactor100Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family
NICE-3 (PF07406, IPR010876): NICE-3 protein
Polysacc_synt_2 (PF02719, IPR003869): Polysaccharide biosynthesis protein

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