Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins LOC105371310, ADAM17 (from a repository: Tue Aug 13 03:04:38 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)14
The number (and %) of the onco-proteins6 (42.86 %)
The number (and %) of the tumor suppressors4 (28.57 %)
Total number of binary PPIs (saturation %)20 (21.98 %)
The number (and %) of affected PPIs12 (60.00 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI2.143
Assortativity coefficient-0.4226
The network average Clustering coefficient0.241
The number (and %) of a zero Clustering coefficients9 (64.29 %)
The number (and %) of a zero Betweenness Centrality11 (78.57 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ADAM17,LOC105371310 All fusions
Proteins found in more fusions TNFRSF1A (see 3 fusions); MAPK1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ADAM17parental protein120.045124.000Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide
Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease
Disintegrin (PF00200, IPR001762, SM00050): Disintegrin
Reprolysin_5 (PF13688): Metallo-peptidase family M12
ADAM17_MPD (PF16698, IPR032029): Membrane-proximal domain, switch, for ADAM17
2 LOC105371310interactor000NA
3 DLG1suppressor100L27_1 (PF09058, IPR015143): L27_1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
KOG2701 (PF09762, IPR019159): Coiled-coil domain-containing protein (DUF2037)
MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
4 EEDsuppressor200WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
5 FBXO6interactor100FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
6 MAD2L1oncoprotein200HORMA (PF02301, IPR003511): HORMA domain
7 MAPK1oncoprotein40.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
8 PDIA3interactor100Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
9 PTCH1suppressor100Patched (PF02460, IPR003392): Patched family
10 PXNoncoprotein21.0000LIM (PF00412, IPR001781, SM00132): LIM domain
Paxillin (PF03535): Paxillin family
11 TGFAoncoprotein100EGF (PF00008, IPR000742, SM00181): EGF-like domain
Lysis_col (PF02402, IPR003059): Lysis protein
TMEM154 (PF15102, IPR028064): TMEM154 protein family
12 TIMP3suppressor100TIMP (PF00965, IPR001820): Tissue inhibitor of metalloproteinase
13 TNFRSF1Aoncoprotein40.6671.000Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
14 TNFRSF1Boncoprotein31.0000TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region

B a c k    t o    T o p ⇑