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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)84
The number (and %) of the onco-proteins20 (23.81 %)
The number (and %) of the tumor suppressors11 (13.10 %)
Total number of binary PPIs (saturation %)317 (9.09 %)
The number (and %) of affected PPIs83 (26.18 %)
The number of possible different fusions12
PPI diameter4
PPI radius2
The average degree of PPI6.833
Assortativity coefficient-0.2137
The network average Clustering coefficient0.472
The number (and %) of a zero Clustering coefficients10 (11.90 %)
The number (and %) of a zero Betweenness Centrality19 (22.62 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions IMPDH2 (see 2 fusions); NDEL1 (see 1 fusions); TSN (see 1 fusions); EGFR (see 2 fusions); SNX1 (see 1 fusions); APEH (see 1 fusions); S100A13 (see 1 fusions); ATP6V1C1 (see 3 fusions); VPS35 (see 2 fusions); STAT1 (see 1 fusions); NEDD4 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SYT1parental protein280.0771849.623C2 (PF00168, IPR000008, SM00239): C2 domain
Comm (PF15957, IPR031878): Commissureless
2 SNX6parental protein550.0863036.079PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
3 ACVR2Binteractor50.40017.366Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
4 ACVRL1interactor21.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
5 ANP32Einteractor60.60016.516BUD22 (PF09073, IPR015158): BUD22
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_9 (PF14580): Leucine-rich repeat
6 APEHoncoprotein70.80011.485Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
7 ARMC1interactor30.66711.842Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HMA (PF00403, IPR006121): Heavy-metal-associated domain
8 ATG7interactor90.66718.989ThiF (PF00899, IPR000594): ThiF family
ATG7_N (PF16420, IPR032197): Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
9 ATP6V1C1protein found in more fusions140.57716.149V-ATPase_C (PF03223, IPR004907): V-ATPase subunit C
10 BMPR1Binteractor200Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
11 BRCA1suppressor70.26759.398BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
12 BRMS1suppressor3012.869Dynactin_p62 (PF05502, IPR008603): Dynactin p62 family
Sds3 (PF08598, IPR013907): Sds3-like
13 C6orf15interactor21.0000STG (PF15809, IPR026135): Simian taste bud-specific gene product family
14 CACNA1Ainteractor100Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain
GRP (PF07172, IPR010800): Glycine rich protein family
Ion_trans (PF00520, IPR005821): Ion transport protein
Roughex (PF06020, IPR009259): Drosophila roughex protein
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
15 CALM1interactor80.286378.822EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
16 CAMKMTinteractor30.6671.071Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
17 CCNL2interactor30.6671.167Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
18 COILinteractor41.0000CDC45 (PF02724, IPR003874): CDC45-like protein
Macoilin (PF09726, IPR019130): Transmembrane protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
19 CSNK2A2interactor70.238159.031Pkinase (PF00069, IPR000719): Protein kinase domain
20 DGUOKinteractor51.0000dNK (PF01712, IPR002624): Deoxynucleoside kinase
21 DISC1interactor30.6671.400HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Mnd1 (PF03962, IPR005647): Mnd1 family
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tropomyosin (PF00261, IPR000533): Tropomyosin
UVR (PF02151, IPR001943): UvrB/uvrC motif
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
22 DNAAF2interactor40.50022.891Glyco_hydro_57 (PF03065, IPR004300): Glycosyl hydrolase family 57
PIH1 (PF08190, IPR012981): pre-RNA processing PIH1/Nop17
23 DNM3interactor50.300141.850Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
24 EGFRoncoprotein130.318162.791Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
25 ELAVL1oncoprotein140.154255.905RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
26 ESR1suppressor110.133108.791Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
27 FAM129Binteractor100.55641.844PH (PF00169, IPR001849, SM00233): PH domain
28 FAM221Ainteractor21.0000FAM221 (PF14753, IPR026755): Protein FAM221A/B
29 FAM43Ainteractor100PID_2 (PF14719, IPR006020): Phosphotyrosine interaction domain (PTB/PID)
30 FGF1oncoprotein40.33337.826FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
31 GATSinteractor21.0000ACT_7 (PF13840, IPR027795): ACT domain
32 GIT1interactor40.6671.622ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
GIT_SHD (PF08518, IPR013724, SM00555): Spa2 homology domain (SHD) of GIT
GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
FlxA (PF14282, IPR025577): FlxA-like protein
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
33 GOLM1interactor100DUF148 (PF02520, IPR003677): Domain of unknown function DUF148
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
GreA_GreB_N (PF03449, IPR022691): Transcription elongation factor, N-terminal
34 GTF2A1oncoprotein50.7001.083TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
35 H3F3Aoncoprotein80.6078.540Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
36 HAX1interactor30.6676.114Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
37 HERC2interactor40.6671.067ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
38 IFI16suppressor60.33330.104HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
39 IKBKGinteractor3011.092CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
40 IMPDH2protein found in more fusions60.50015.698IMPDH (PF00478, IPR001093): IMP dehydrogenase / GMP reductase domain
41 INSRinteractor70.38145.358fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
42 LEPRoncoprotein40.8330.400fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Lep_receptor_Ig (PF06328, IPR010457): Ig-like C2-type domain
43 NDEL1protein found in more fusions31.0000HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
44 NEDD4suppressor80.238103.867Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
45 NTRK1oncoprotein240.158915.049I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
46 NUFIP1interactor60.40071.876NUFIP1 (PF10453, IPR019496): Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)
DUF3395 (PF11875, IPR024586): Domain of unknown function (DUF3395)
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
47 PAWRsuppressor100.6895.902ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
48 PCID2interactor70.38119.310PCI (PF01399, IPR000717, SM00088): PCI domain
49 PDGFRAoncoprotein90.53627.890Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
LAT (PF15234, IPR008359): Linker for activation of T-cells
50 PHLPP1suppressor30.6672.844LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
PH (PF00169, IPR001849, SM00233): PH domain
PP2C (PF00481, IPR001932): Protein phosphatase 2C
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
PRIMA1 (PF16101): Proline-rich membrane anchor 1
51 PIM1oncoprotein50.5004.596Pkinase (PF00069, IPR000719): Protein kinase domain
52 RBM14suppressor50.20058.510RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
53 RTF1interactor40.50011.801K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Plus-3 (PF03126, IPR004343): Plus-3 domain
V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
YL1 (PF05764, IPR008895): YL1 nuclear protein
AAA_23 (PF13476): AAA domain
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
54 S100A13oncoprotein31.0000S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
55 SHMT1interactor120.60013.869SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
56 SHMT2interactor140.39667.956SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
57 SIN3Aoncoprotein50.20069.366Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
58 SMAD2suppressor100.056210.971MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
59 SNAP25interactor90.50019.089SNAP-25 (PF00835, IPR000928): SNAP-25 family
Use1 (PF09753, IPR019150): Membrane fusion protein Use1
60 SNX1protein found in more fusions160.40089.065PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
61 SNX2interactor280.225469.263PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
62 SNX4interactor60.6674.005PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
63 STAT1suppressor170.41782.312SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
64 STON2interactor100Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Stonin2_N (PF12016, IPR022699): Stonin 2
65 STX1Ainteractor90.46435.854Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
4HB_MCP_1 (PF12729, IPR024478): Four helix bundle sensory module for signal transduction
66 STX2interactor50.40044.533Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
67 STX3interactor41.0000XhlA (PF10779, IPR019715): Haemolysin XhlA
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
68 STX4oncoprotein60.70020.999Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
69 SV2Binteractor21.0000MFS_1 (PF07690, IPR011701): Major Facilitator Superfamily
Sugar_tr (PF00083, IPR005828): Sugar (and other) transporter
Pentapeptide_4 (PF13599, IPR001646): Pentapeptide repeats (9 copies)
70 SV2Cinteractor100FixH (PF05751, IPR008620): FixH
MFS_1 (PF07690, IPR011701): Major Facilitator Superfamily
Sugar_tr (PF00083, IPR005828): Sugar (and other) transporter
Pentapeptide_4 (PF13599, IPR001646): Pentapeptide repeats (9 copies)
Neurensin (PF14927): Neurensin
71 SYNCRIPinteractor50.20065.458RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
72 SYT5interactor200C2 (PF00168, IPR000008, SM00239): C2 domain
MLANA (PF14991, IPR029242): Protein melan-A
73 TEAD4interactor100TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
74 TGFBR1oncoprotein50.40030.808Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
75 TGFBR2suppressor40.5002.524ecTbetaR2 (PF08917, IPR015013): Transforming growth factor beta receptor 2 ectodomain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
76 TNIKinteractor30.33321.045CNH (PF00780, IPR001180, SM00036): CNH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
DUF3499 (PF12005, IPR021888): Protein of unknown function (DUF3499)
CNDH2_M (PF16869): PF16858
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
77 TREML2interactor21.0000Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
78 TSNprotein found in more fusions80.7144.380Translin (PF01997, IPR002848): Translin family
79 TSNAXinteractor40.33321.700Translin (PF01997, IPR002848): Translin family
80 USP46interactor30.6671.000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
81 VAMP2interactor100.44482.121Synaptobrevin (PF00957, IPR001388): Synaptobrevin
PRIMA1 (PF16101): Proline-rich membrane anchor 1
82 VAPBinteractor70.238317.749ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
ZapB (PF06005, IPR009252): Cell division protein ZapB
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
83 VPS29interactor110.6916.321Metallophos_2 (PF12850, IPR024654): Calcineurin-like phosphoesterase superfamily domain
84 VPS35protein found in more fusions130.48541.182FerA (PF08165, IPR012560): FerA (NUC095) domain
Vps35 (PF03635, IPR005378): Vacuolar protein sorting-associated protein 35

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