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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ERCC1, NEK4 (from a repository: Wed Jul 31 18:00:27 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)51
The number (and %) of the onco-proteins11 (21.57 %)
The number (and %) of the tumor suppressors4 (7.84 %)
Total number of binary PPIs (saturation %)122 (9.57 %)
The number (and %) of affected PPIs49 (40.16 %)
The number of possible different fusions9
PPI diameter5
PPI radius3
The average degree of PPI4.235
Assortativity coefficient-0.2336
The network average Clustering coefficient0.457
The number (and %) of a zero Clustering coefficients16 (31.37 %)
The number (and %) of a zero Betweenness Centrality23 (45.10 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ERCC1,NEK4 All fusions
Proteins found in more fusions MSH2 (see 1 fusions); POLR2A (see 2 fusions); HLA-C (see 1 fusions); FANCG (see 1 fusions); APP (see 5 fusions); HLA-B (see 4 fusions); HLA-B/HLA-C (see 4 fusions); TOPBP1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ERCC1parental protein300.1011159.476Rad10 (PF03834, IPR004579): Binding domain of DNA repair protein Ercc1 (rad10/Swi10)
HHH_5 (PF14520): Helix-hairpin-helix domain
2 NEK4parental protein190.0291224.594Pkinase (PF00069, IPR000719): Protein kinase domain
Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
3 ACAT1interactor31.0000Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
4 ANKRD28interactor21.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
5 APPprotein found in more fusions60.200254.602APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 C15orf40interactor100DUF167 (PF02594, IPR003746, SM01152): Uncharacterised ACR, YggU family COG1872
7 C4BPBinteractor100Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
8 CBWD1interactor21.0000cobW (PF02492, IPR003495): CobW/HypB/UreG, nucleotide-binding domain
CobW_C (PF07683, IPR011629, SM00833): Cobalamin synthesis protein cobW C-terminal domain
9 CBWD2interactor21.0000cobW (PF02492, IPR003495): CobW/HypB/UreG, nucleotide-binding domain
CobW_C (PF07683, IPR011629, SM00833): Cobalamin synthesis protein cobW C-terminal domain
10 CDC5Linteractor40.333101.888OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
11 CTDSP2interactor20101.523NIF (PF03031, IPR004274): NLI interacting factor-like phosphatase
12 DNAJB2interactor100DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
13 ERCC4oncoprotein120.31888.505ERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain
LUC7 (PF03194, IPR004882): LUC7 N_terminus
T2SSM_b (PF10741, IPR007690): Type II secretion system (T2SS), protein M subtype b
HHH_5 (PF14520): Helix-hairpin-helix domain
14 FANCGsuppressor50.33390.641BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain
Hpt (PF01627, IPR008207, SM00073): Hpt domain
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
15 GTF2H1oncoprotein50.7003.667BSD (PF03909, IPR005607, SM00751): BSD domain
PH_TFIIH (PF08567, IPR013876): TFIIH p62 subunit, N-terminal domain
16 HLA-Boncoprotein41.0000MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
17 HLA-Cprotein found in more fusions41.0000Marek_A (PF02124, IPR001038): Marek's disease glycoprotein A
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
18 HLA-Einteractor31.0000MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
AA_permease_C (PF13906, IPR029485): C-terminus of AA_permease
19 ISLRinteractor100I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
20 MAGIXinteractor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
21 MKRN3oncoprotein200zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
MKRN1_C (PF15815, IPR031644): E3 ubiquitin-protein ligase makorin-1, C-terminal
Torus (PF16131, IPR032297): Torus domain
zf-3CxxC_2 (PF17180): Zinc-binding domain
22 MSH2suppressor60.6006.783MutS_I (PF01624, IPR007695): MutS domain I
MutS_II (PF05188, IPR007860): MutS domain II
MutS_V (PF00488, IPR000432, SM00534): MutS domain V
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
AAA_27 (PF13514): AAA domain
23 MUS81suppressor50.6002.500ERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain
MutL (PF13941, IPR006230): MutL protein
HHH_8 (PF14716, IPR010996): Helix-hairpin-helix domain
24 NRG1interactor2082.472EGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neuregulin (PF02158, IPR002154): Neuregulin family
25 PLAURoncoprotein100Toxin_1 (PF00087, IPR003571): Snake toxin
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
26 POLR2Aprotein found in more fusions90.357241.452RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
27 RPGRIP1interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
RNA_binding (PF01877, IPR002739): RNA binding
DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
C2-C2_1 (PF11618, IPR021656): First C2 domain of RPGR-interacting protein 1
COX16 (PF14138, IPR020164): Cytochrome c oxidase assembly protein COX16
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
28 RPGRIP1Linteractor21.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
C2 (PF00168, IPR000008, SM00239): C2 domain
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FtsL (PF04999, IPR011922): Cell division protein FtsL
T3SS_needle_F (PF09392, IPR021123): Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
C2-C2_1 (PF11618, IPR021656): First C2 domain of RPGR-interacting protein 1
BNIP2 (PF12496, IPR022181): Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4497 (PF14924): Protein of unknown function (DUF4497)
29 SDF4interactor2089.856Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
30 SKAP1interactor3089.856PH (PF00169, IPR001849, SM00233): PH domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
31 SLX1Ainteractor40.8330.400GIY-YIG (PF01541, IPR000305, SM00465): GIY-YIG catalytic domain
FANCL_C (PF11793, IPR026850): FANCL C-terminal domain
32 SLX1Binteractor50.8001.067GIY-YIG (PF01541, IPR000305, SM00465): GIY-YIG catalytic domain
FANCL_C (PF11793, IPR026850): FANCL C-terminal domain
33 SLX4suppressor100.37864.900BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Slx4 (PF09494, IPR018574): Slx4 endonuclease
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
34 SLX4IPinteractor41.0000UPF0492 (PF15744, IPR031479): Uncharacterized protein family UPF0492
35 SPACA1interactor100DUF912 (PF06024, IPR009261): Nucleopolyhedrovirus protein of unknown function (DUF912)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
36 TAF10interactor60.7339.167TFIID_30kDa (PF03540, IPR003923): Transcription initiation factor TFIID 23-30kDa subunit
37 TAF12interactor50.60078.358TFIID_20kDa (PF03847, IPR003228): Transcription initiation factor TFIID subunit A
38 TAF6interactor60.66716.974CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
Spo0A_C (PF08769, IPR014879): Sporulation initiation factor Spo0A C terminal
TAF (PF02969, IPR004823, SM00803): TATA box binding protein associated factor (TAF)
39 TAF7interactor41.0000DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ELM2 (PF01448, IPR000949): ELM2 domain
TAFII55_N (PF04658, IPR006751): TAFII55 protein conserved region
XhlA (PF10779, IPR019715): Haemolysin XhlA
Noelin-1 (PF12308, IPR022082): Neurogenesis glycoprotein
40 TBPinteractor70.7339.167TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
41 TOPBP1protein found in more fusions40.6671.000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
42 TRMT2Binteractor100tRNA_U5-meth_tr (PF05958, IPR010280): tRNA (Uracil-5-)-methyltransferase
43 TWF2interactor30.33370.854Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
44 TXNDC15interactor100Thioredoxin (PF00085, IPR013766): Thioredoxin
45 UBL7oncoprotein21.0000UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
46 UHRF1interactor40.6670.400PHD (PF00628, IPR019787, SM00249): PHD-finger
SAD_SRA (PF02182, IPR003105, SM00466): SAD/SRA domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
TTD (PF12148, IPR021991): Tandem tudor domain within UHRF1
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
47 USHBP1interactor40.6670.667DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
SlyX (PF04102, IPR007236): SlyX
MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome
YlqD (PF11068, IPR021297): YlqD protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
CAGE1 (PF15066, IPR029381): Cancer-associated gene protein 1 family
TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family
48 USP45interactor31.0000HNH (PF01844, IPR002711): HNH endonuclease
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
LELP1 (PF15042, IPR026076): Late cornified envelope-like proline-rich protein 1
49 VPS37Binteractor2038.854Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
50 XPAoncoprotein60.60088.424XPA_C (PF05181, IPR022656): XPA protein C-terminus
XPA_N (PF01286, IPR022652): XPA protein N-terminal
MscS_TM (PF12794, IPR025692): Mechanosensitive ion channel inner membrane domain 1
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
51 XPO1interactor70.048607.954CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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