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Visible interactions: all affected independent (normal) nothing (blank)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)56
The number (and %) of the onco-proteins16 (28.57 %)
The number (and %) of the tumor suppressors8 (14.29 %)
Total number of binary PPIs (saturation %)178 (11.56 %)
The number (and %) of affected PPIs56 (31.46 %)
The number of possible different fusions11
PPI diameter4
PPI radius2
The average degree of PPI5.250
Assortativity coefficient-0.3263
The network average Clustering coefficient0.249
The number (and %) of a zero Clustering coefficients24 (42.86 %)
The number (and %) of a zero Betweenness Centrality18 (32.14 %)


List of the fusions

PPI for parental proteins: EMG1,SRI All fusions
Proteins found in more fusions TCF12 (see 2 fusions); STAT3 (see 2 fusions); RYR2 (see 1 fusions); APP (see 4 fusions); KHDRBS1 (see 1 fusions); SRPK2 (see 1 fusions); TKT (see 5 fusions); RPA1 (see 1 fusions); SSNA1 (see 1 fusions); NPM1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 EMG1parental protein210.110729.194EMG1 (PF03587, IPR005304): EMG1/NEP1 methyltransferase
2 SRIparental protein350.0621615.045EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
3 ALG2interactor40.6670.618Glycos_transf_1 (PF00534, IPR001296): Glycosyl transferases group 1
Glyco_transf_4 (PF13439, IPR028098): Glycosyltransferase Family 4
4 ANXA7suppressor60.33330.141Annexin (PF00191, IPR018502, SM00335): Annexin
5 APPprotein found in more fusions120.127161.803APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 ATXN3interactor40.3338.300Josephin (PF02099, IPR006155): Josephin
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
7 BTRConcoprotein303.630WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
8 BYSLinteractor50.6006.062Bystin (PF05291, IPR007955): Bystin
MEA1 (PF06910, IPR009685): Male enhanced antigen 1 (MEA1)
9 C12orf57interactor100P_C10 (PF14974, IPR026317): Protein C10
10 CACNA1Cinteractor21.0000Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain
Ion_trans (PF00520, IPR005821): Ion transport protein
Rer1 (PF03248, IPR004932): Rer1 family
ODV-E18 (PF10717, IPR019655): Occlusion-derived virus envelope protein ODV-E18
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
CAC1F_C (PF16885, IPR031688): Voltage-gated calcium channel subunit alpha, C-term
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
11 CACNA1Sinteractor100Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain
Ion_trans (PF00520, IPR005821): Ion transport protein
Tetraspannin (PF00335, IPR018499): Tetraspanin family
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
COX16 (PF14138, IPR020164): Cytochrome c oxidase assembly protein COX16
CAC1F_C (PF16885, IPR031688): Voltage-gated calcium channel subunit alpha, C-term
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
12 CALCOCO2interactor307.647bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
13 CEP290interactor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
Fez1 (PF06818): Fez1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
HemY_N (PF07219, IPR010817): HemY protein N-terminus
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Mnd1 (PF03962, IPR005647): Mnd1 family
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Rho_Binding (PF08912, IPR015008): Rho Binding
Sec20 (PF03908, IPR005606): Sec20
Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Swi5 (PF07061, IPR010760): Swi5
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
LIDHydrolase (PF10230, IPR019363): Lipid-droplet associated hydrolase
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
FAM76 (PF16046, IPR032017): FAM76 protein
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
CEP209_CC5 (PF16574, IPR032321): Coiled-coil region of centrosome protein CE290
14 EEDsuppressor60.10029.396WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
15 EMC2interactor205.282TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_19 (PF14559): Tetratricopeptide repeat
Alkyl_sulf_dimr (PF14863, IPR029228): Alkyl sulfatase dimerisation
16 ENO1oncoprotein110.345120.205Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
17 FAM74A4interactor100NA
18 FN1oncoprotein110.418256.590fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
19 GCAinteractor200EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
DUF2835 (PF11197, IPR021363): Protein of unknown function (DUF2835)
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
20 HAUS2interactor100DpnII (PF04556, IPR007637): DpnII restriction endonuclease
HAUS2 (PF15003, IPR028346): HAUS augmin-like complex subunit 2
21 HECW2interactor200C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
22 IFI16suppressor60.33342.924HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
23 IL7Rinteractor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
24 ITGA4interactor110.46753.748FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
25 KHDRBS1protein found in more fusions90.28668.964KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
26 MPIinteractor30.3338.767PMI_typeI (PF01238, IPR001250): Phosphomannose isomerase type I
27 MYH14interactor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
28 NANOGinteractor303.812Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
29 NPM1suppressor130.37956.788Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
30 NRASoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
31 OBSL1interactor70.20034.088BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
32 PDCD6IPinteractor100.44447.266BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
33 PDE4Cinteractor100PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase
34 PIRinteractor60.6676.244Pirin (PF02678, IPR003829): Pirin
Pirin_C (PF05726, IPR008778): Pirin C-terminal cupin domain
35 POU5F1oncoprotein303.812Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
36 PRR13interactor200DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
37 PSEN2oncoprotein305.483Herpes_LMP1 (PF05297, IPR007961): Herpesvirus latent membrane protein 1 (LMP1)
Presenilin (PF01080, IPR001108): Presenilin
38 RPA1suppressor90.53643.894Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
39 RPA2oncoprotein100.40072.386RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
40 RPA3interactor70.7336.008Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
41 RPL10suppressor60.53310.643Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
42 RUVBL1oncoprotein4022.591TIP49 (PF06068, IPR010339): TIP49 C-terminus
43 RYR2protein found in more fusions31.0000Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor
Ion_trans (PF00520, IPR005821): Ion transport protein
MIR (PF02815, IPR016093, SM00472): MIR domain
RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
RYDR_ITPR (PF01365, IPR000699): RIH domain
RyR (PF02026, IPR003032): RyR domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
SRP72 (PF08492, IPR013699): SRP72 RNA-binding domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
YjfB_motility (PF14070, IPR025906): Putative motility protein
44 SHBGoncoprotein200Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
45 SLC25A38interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
TRAPP (PF04051, IPR007194): Transport protein particle (TRAPP) component
46 SMAD2suppressor50.33326.707MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
47 SNCAinteractor305.483Synuclein (PF01387, IPR001058): Synuclein
48 SOD1interactor90.46424.491Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
49 SRPK2oncoprotein5033.695DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
50 SSNA1protein found in more fusions200APG6 (PF04111, IPR007243): Autophagy protein Apg6
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
51 STAT3suppressor40.33319.246SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
52 TCF12oncoprotein31.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
53 TIAL1interactor120.197228.878RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
54 TKTprotein found in more fusions100.44444.156Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
55 VAPAinteractor70.33366.130DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
56 VCAM1interactor90.41773.883C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain

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