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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MAGI2, SPINK1 (from a repository: Wed May 31 16:31:21 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)12
The number (and %) of the onco-proteins4 (33.33 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)13 (19.70 %)
The number (and %) of affected PPIs10 (76.92 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI1.667
Assortativity coefficient0
The network average Clustering coefficient0.000
The number (and %) of a zero Clustering coefficients12 (100.00 %)
The number (and %) of a zero Betweenness Centrality11 (91.67 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SPINK1,MAGI2 All fusions
Proteins found in more fusions ATN1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SPINK1parental protein100Kazal_1 (PF00050, IPR002350): Kazal-type serine protease inhibitor domain
2 MAGI2parental protein9072.000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
WW (PF00397, IPR001202, SM00456): WW domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
PDZ_2 (PF13180, IPR001478): PDZ domain
MAGI_u1 (PF16663): Unstructured region on MAGI
MAGI_u5 (PF16666): Unstructured region on MAGI
3 ACVR2Aoncoprotein100Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
4 ADGRB1interactor2007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
GPS (PF01825, IPR000203, SM00303): GPCR proteolysis site, GPS, motif
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
GAIN (PF16489, IPR032471): GPCR-Autoproteolysis INducing (GAIN) domain
5 ADRB1interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PRIMA1 (PF16101): Proline-rich membrane anchor 1
6 ARRDC3interactor100Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
7 ATN1protein found in more fusions200Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
8 CTNNB1oncoprotein100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
9 DSCAML1interactor100ChitinaseA_N (PF08329, IPR013540): Chitinase A, N-terminal domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
10 PLXNB3interactor100Plexin_cytopl (PF08337, IPR013548): Plexin cytoplasmic RasGAP domain
PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
Taeniidae_ag (PF05596, IPR008860): Taeniidae antigen
TIG (PF01833, IPR002909): IPT/TIG domain
11 TTBK1interactor100Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
Pkinase (PF00069, IPR000719): Protein kinase domain
RXT2_N (PF08595, IPR013904): RXT2-like, N-terminal
Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
12 UBE3Aoncoprotein200HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A

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