Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins SOX5 (from a repository: Tue Dec 6 16:00:07 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
Layout Tree Circle Radial Force Directed Preset
Export graph PNG file PDF file SVG file SIF file XML file GraphML file

Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 29 The number (and %) of the onco-proteins 8 (27.59 %) The number (and %) of the tumor suppressors 2 (6.90 %) Total number of binary PPIs (saturation %) 59 (14.53 %) The number (and %) of affected PPIs 29 (49.15 %) The number of possible different fusions 6 PPI diameter 2 PPI radius 1 The average degree of PPI 3.103 Assortativity coefficient -0.4259 The network average Clustering coefficient 0.456 The number (and %) of a zero Clustering coefficients 11 (37.93 %) The number (and %) of a zero Betweenness Centrality 20 (68.97 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: SOX5	All fusions
Proteins found in more fusions	APP (see 4 fusions); KAT5 (see 3 fusions); AES (see 3 fusions); CDK6 (see 1 fusions); SOX5 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	SOX5	parental protein	29	0.045	690.333	HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box SOAR (PF16533, IPR032393): STIM1 Orai1-activating region MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
2	AES	protein found in more fusions	6	0.400	6.000	TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
3	APP	protein found in more fusions	8	0.286	14.667	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4	ARID5A	oncoprotein	1	0	0	ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
5	CBX8	interactor	4	0.667	0.667	Atrophin-1 (PF03154, IPR002951): Atrophin-1 family Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain RBR (PF17208): RNA binding Region CBX7_C (PF17218): CBX family C-terminal motif
6	CDC23	interactor	3	1.000	0	ANAPC8 (PF04049, IPR007192): Anaphase promoting complex subunit 8 / Cdc23 DUF772 (PF05598, IPR008490): Transposase domain (DUF772) Menin (PF05053, IPR007747): Menin TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_14 (PF13428): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
7	CDC25A	oncoprotein	4	0.500	3.000	M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
8	CDK6	suppressor	2	0	0	Pkinase (PF00069, IPR000719): Protein kinase domain
9	CEP85	interactor	1	0	0	DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 SlyX (PF04102, IPR007236): SlyX Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 KLRAQ (PF10205, IPR019343): Predicted coiled-coil domain-containing protein ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
10	CRX	interactor	2	1.000	0	TF_Otx (PF03529, IPR013851): Otx1 transcription factor Homeobox (PF00046, IPR001356, SM00389): Homeobox domain SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
11	FAM46B	interactor	1	0	0	NTP_transf_7 (PF07984, IPR012937, SM01153): Nucleotidyltransferase
12	FTH1	interactor	3	1.000	0	Coat_F (PF07875, IPR012851): Coat F domain Ferritin (PF00210, IPR008331): Ferritin-like domain
13	KAT5	suppressor	4	0.667	0.667	MOZ_SAS (PF01853, IPR002717): MOZ/SAS family Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
14	KIFC3	oncoprotein	5	0.500	2.667	Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein KxDL (PF10241, IPR019371): Uncharacterized conserved protein Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
15	LMO1	oncoprotein	2	1.000	0	LIM (PF00412, IPR001781, SM00132): LIM domain Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
16	LMO2	oncoprotein	4	0.667	1.000	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal LIM (PF00412, IPR001781, SM00132): LIM domain
17	MED27	interactor	1	0	0	Med27 (PF11571, IPR021627): Mediator complex subunit 27
18	MORN3	interactor	1	0	0	MORN (PF02493, IPR003409, SM00698): MORN repeat TFIIIC_sub6 (PF10419, IPR019481): TFIIIC subunit
19	PRR20A	interactor	2	0	0	PRR20 (PF15708, IPR031439): Proline-rich protein family 20
20	RPS2	interactor	1	0	0	Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
21	SMAD1	interactor	5	0.500	3.000	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
22	SMAD5	interactor	2	1.000	0	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
23	SMAD7	interactor	2	1.000	0	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
24	SOX2	oncoprotein	3	1.000	0	HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box SOXp (PF12336, IPR022097): SOX transcription factor
25	SUMO1P1	interactor	2	0	0	NA
26	TAF6	interactor	2	1.000	0	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain Spo0A_C (PF08769, IPR014879): Sporulation initiation factor Spo0A C terminal TAF (PF02969, IPR004823, SM00803): TATA box binding protein associated factor (TAF)
27	TTC1	interactor	1	0	0	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
28	UQCRFS1	interactor	1	0	0	Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
29	ZNF581	interactor	2	1.000	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger

B a c k    t o    T o p ⇑