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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)54
The number (and %) of the onco-proteins16 (29.63 %)
The number (and %) of the tumor suppressors11 (20.37 %)
Total number of binary PPIs (saturation %)200 (13.98 %)
The number (and %) of affected PPIs53 (26.50 %)
The number of possible different fusions10
PPI diameter4
PPI radius2
The average degree of PPI6.630
Assortativity coefficient-0.2526
The network average Clustering coefficient0.477
The number (and %) of a zero Clustering coefficients8 (14.81 %)
The number (and %) of a zero Betweenness Centrality16 (29.63 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SMARCA1,CNP All fusions
Proteins found in more fusions SMARCC1 (see 2 fusions); GRK5 (see 4 fusions); PARP1 (see 1 fusions); PEX14 (see 1 fusions); CRY2 (see 3 fusions); USF1 (see 3 fusions); EGFR (see 2 fusions); ZDHHC17 (see 2 fusions); MCM2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SMARCA1parental protein350.139903.362ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
HAND (PF09110, IPR015194): HAND
SLIDE (PF09111, IPR015195): SLIDE
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DBINO (PF13892, IPR020838): DNA-binding domain
2 CNPparental protein180.092729.834CNPase (PF05881, IPR008431): 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)
NB-ARC (PF00931, IPR002182): NB-ARC domain
AAA_33 (PF13671): AAA domain
3 ARID1Boncoprotein50.7002.733ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Presenilin (PF01080, IPR001108): Presenilin
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
DUF2235 (PF09994, IPR018712): Uncharacterized alpha/beta hydrolase domain (DUF2235)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
BAF250_C (PF12031, IPR021906): SWI/SNF-like complex subunit BAF250/Osa
Spt20 (PF12090, IPR021950): Spt20 family
4 BPTFinteractor90.55611.924Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
DDT (PF02791, IPR004022, SM00571): DDT domain
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
GRP (PF07172, IPR010800): Glycine rich protein family
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
PHD (PF00628, IPR019787, SM00249): PHD-finger
SDA1 (PF05285, IPR007949): SDA1
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
WHIM1 (PF15612, IPR028942): WSTF, HB1, Itc1p, MBD9 motif 1
WSD (PF15613, IPR028941): Williams-Beuren syndrome DDT (WSD), D-TOX E motif
CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
5 C17orf49interactor60.8670.583Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
6 CCDC8interactor110.178122.348Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
7 CIAO1interactor31.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
8 CRY2protein found in more fusions305.754DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
9 DDX21interactor70.38117.061CRT10 (PF08728, IPR014839): CRT10
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
GUCT (PF08152, IPR012562): GUCT (NUC152) domain
Sulfatase (PF00884, IPR000917): Sulfatase
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
10 DEF6interactor100ArgK (PF03308, IPR005129): ArgK protein
HSP70 (PF00012, IPR013126): Hsp70 protein
PH (PF00169, IPR001849, SM00233): PH domain
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
EF-hand_6 (PF13405, IPR002048): EF-hand domain
11 EEDsuppressor130.45529.605WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
12 EGFRoncoprotein41.0000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
13 FAM96Binteractor40.8332.702DUF59 (PF01883, IPR002744): Domain of unknown function DUF59
14 FOXC1suppressor50.5009.482TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
PAF (PF15715, IPR031444): PCNA-associated factor
PRIMA1 (PF16101): Proline-rich membrane anchor 1
15 FOXE1oncoprotein40.6671.200Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
16 FOXG1oncoprotein21.0000SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SPX (PF03105, IPR004331): SPX domain
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
17 FOXJ2interactor31.0000SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
Spt20 (PF12090, IPR021950): Spt20 family
Pro-rich (PF15240, IPR026086): Proline-rich
18 FOXK2interactor90.47222.983FHA (PF00498, IPR000253, SM00240): FHA domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
19 FOXL1oncoprotein21.0000Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
20 FOXQ1interactor21.0000Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
21 GRK5protein found in more fusions50.33318.059Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
22 HIST1H3Ainteractor100.50044.224Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
23 IFI16suppressor31.0000HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
24 MAXsuppressor60.6005.248ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SlyX (PF04102, IPR007236): SlyX
25 MCM2oncoprotein90.28697.604AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
26 MED20interactor21.0000Med20 (PF08612, IPR013921): TATA-binding related factor (TRF) of subunit 20 of Mediator complex
27 MED23interactor50.30060.165Med23 (PF11573, IPR021629): Mediator complex subunit 23
28 MMS19interactor80.35775.881DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
29 MTNR1Ainteractor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
TctB (PF07331, IPR009936): Tripartite tricarboxylate transporter TctB family
30 NANOGinteractor60.20026.364Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
31 NMIinteractor200IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
32 NTRK1oncoprotein170.250381.622I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
33 PARP1suppressor80.33350.825BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
WGR (PF05406, IPR008893, SM00773): WGR domain
zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
34 PEX14protein found in more fusions307.370HemX (PF04375, IPR007470): HemX, putative uroporphyrinogen-III C-methyltransferase
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
35 PGRsuppressor40.6671.143Prog_receptor (PF02161, IPR000128): Progesterone receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
36 POLE3interactor21.0000BUD22 (PF09073, IPR015158): BUD22
CBFD_NFYB_HMF (PF00808, IPR003958): Histone-like transcription factor (CBF/NF-Y) and archaeal histone
37 PPP1CAsuppressor60.46779.001Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
38 PRNPinteractor100Prion (PF00377, IPR022416): Prion/Doppel alpha-helical domain
Prion_octapep (PF03991, IPR020949): Copper binding octapeptide repeat
Prion_bPrPp (PF11587, IPR025860): Major prion protein bPrPp - N terminal
39 RBBP4oncoprotein110.56429.225eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
40 RBBP7suppressor110.54527.286WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
41 RBPJinteractor40.33322.199BTD (PF09270, IPR015350): Beta-trefoil DNA-binding domain
LAG1-DNAbind (PF09271, IPR015351): LAG1, DNA binding
TIG (PF01833, IPR002909): IPT/TIG domain
42 RPS2interactor40.16753.464Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
43 RUVBL1oncoprotein110.40045.102TIP49 (PF06068, IPR010339): TIP49 C-terminus
44 SETD1Ainteractor30.6670.446E7 (PF00527, IPR000148): E7 protein, Early protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SET (PF00856, IPR001214, SM00317): SET domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
N-SET (PF11764, IPR024657): COMPASS (Complex proteins associated with Set1p) component N
DUF4632 (PF15451, IPR027952): Domain of unknown function (DUF4632)
DUF4667 (PF15700, IPR031426): Domain of unknown function (DUF4667)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
45 SIRT3suppressor100SIR2 (PF02146, IPR003000): Sir2 family
46 SMARCA4suppressor110.40035.488DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
BRK (PF07533, IPR006576, SM00592): BRK domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065)
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
47 SMARCA5interactor270.197398.690HAND (PF09110, IPR015194): HAND
SLIDE (PF09111, IPR015195): SLIDE
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DBINO (PF13892, IPR020838): DNA-binding domain
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
48 SMARCC1suppressor90.64310.631SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF2618 (PF10940, IPR021237): Protein of unknown function (DUF2618)
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
49 SMARCC2interactor120.409101.409GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
50 SOX2oncoprotein120.218180.479HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
51 TEAD2interactor40.6671.658TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
52 TFPToncoprotein31.0000GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
53 USF1oncoprotein100.41716.847HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
54 ZDHHC17protein found in more fusions200zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)

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