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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ZNF133, BMPR2 (from a repository: Sun May 21 12:48:08 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)39
The number (and %) of the onco-proteins12 (30.77 %)
The number (and %) of the tumor suppressors8 (20.51 %)
Total number of binary PPIs (saturation %)98 (13.23 %)
The number (and %) of affected PPIs38 (38.78 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI4.051
Assortativity coefficient-0.3638
The network average Clustering coefficient0.407
The number (and %) of a zero Clustering coefficients14 (35.90 %)
The number (and %) of a zero Betweenness Centrality17 (43.59 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: ZNF133,BMPR2 All fusions
: AK074502;
Proteins found in more fusions FOS (see 4 fusions); BMPR1A (see 1 fusions); ILK (see 1 fusions); LIMK1 (see 1 fusions); FRS3 (see 1 fusions); TRIM28 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ZNF133parental protein70.143124.500zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
2 BMPR2parental protein310.0761024.192Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Cadherin_C_2 (PF16492, IPR032455): Cadherin cytoplasmic C-terminal
3 ACVR1interactor80.6199.415Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
4 ACVR1Boncoprotein50.7004.900Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
5 BMP10suppressor100TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
6 BMP2suppressor31.0000TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
7 BMP4suppressor31.0000TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
8 BMP6interactor21.0000TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
9 BMP7interactor60.50077.726TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
10 BMPR1Asuppressor140.29565.053Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
11 BMPR1Binteractor100.38931.562Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
12 CAV1suppressor30.6670.500Caveolin (PF01146, IPR001612): Caveolin
13 CES3interactor100COesterase (PF00135, IPR002018): Carboxylesterase family
14 CRYABoncoprotein31.0000Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
15 FHL2oncoprotein3031.410LIM (PF00412, IPR001781, SM00132): LIM domain
zf-ribbon_3 (PF13248): zinc-ribbon domain
16 FOSoncoprotein200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
17 FRS3suppressor200IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
18 FSToncoprotein21.0000FOLN (PF09289, IPR015369, SM00274): Follistatin/Osteonectin-like EGF domain
Kazal_2 (PF07648, IPR002350, SM00280): Kazal-type serine protease inhibitor domain
Ecl1 (PF12855, IPR024368): Life-span regulatory factor
19 GCGRinteractor1007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
20 GDF2interactor100TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
21 GDF5interactor40.8330.400TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
22 GDF6interactor31.0000TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
23 GDF9interactor21.0000CAMSAP_CKK (PF08683, IPR014797, SM01051): Microtubule-binding calmodulin-regulated spectrin-associated
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
24 ILKsuppressor40.6672.333Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
25 KRTAP10-7interactor3030.292Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
26 LIMK1oncoprotein200LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
27 MAPK6oncoprotein3042.370Pkinase (PF00069, IPR000719): Protein kinase domain
28 MAPK8oncoprotein3086.410DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
29 MDM2oncoprotein50.16756.718Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
30 PDPK1interactor40.33341.743Pkinase (PF00069, IPR000719): Protein kinase domain
PH_3 (PF14593): PH domain
31 PPP1CConcoprotein2081.410Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
32 PYCARDsuppressor200CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
33 SMAD6interactor80.46494.737MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
34 SMAD7interactor60.7332.333MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
35 TGFBR1oncoprotein40.6672.444Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
36 TRIB3interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
37 TRIM28protein found in more fusions50.33347.310ASFV_J13L (PF05568, IPR008385): African swine fever virus J13L protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
38 TSR1interactor100AARP2CN (PF08142, IPR012948, SM00785): AARP2CN (NUC121) domain
RIBIOP_C (PF04950, IPR007034): 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
NUSAP (PF16006, IPR026756): Nucleolar and spindle-associated protein
39 XIAPinteractor60.30060.242BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ACVR1interactorActivin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
AK074502
2 ACVR1BoncoproteinActivin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
AK074502
3 BMP10suppressorTGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
AK074502
4 BMP2suppressorTGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
AK074502
5 BMP4suppressorTGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
AK074502
6 BMP6interactorTGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
AK074502
7 BMP7interactorTGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
AK074502
8 BMPR1AsuppressorActivin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
AK074502
9 BMPR1BinteractorActivin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
AK074502
10 BMPR2parental proteinActivin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Cadherin_C_2 (PF16492, IPR032455): Cadherin cytoplasmic C-terminal
AK074502
11 CAV1suppressorCaveolin (PF01146, IPR001612): CaveolinAK074502
12 CES3interactorCOesterase (PF00135, IPR002018): Carboxylesterase familyAK074502
13 CRYABoncoproteinCrystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
AK074502
14 FHL2oncoproteinLIM (PF00412, IPR001781, SM00132): LIM domain
zf-ribbon_3 (PF13248): zinc-ribbon domain
AK074502
15 FOSoncoproteinbZIP_1 (PF00170, IPR004827): bZIP transcription factorAK074502
16 FRS3suppressorIRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)AK074502
17 FSToncoproteinFOLN (PF09289, IPR015369, SM00274): Follistatin/Osteonectin-like EGF domain
Kazal_2 (PF07648, IPR002350, SM00280): Kazal-type serine protease inhibitor domain
Ecl1 (PF12855, IPR024368): Life-span regulatory factor
AK074502
18 GCGRinteractor7tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
AK074502
19 GDF2interactorTGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
AK074502
20 GDF5interactorTGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
AK074502
21 GDF6interactorTGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
AK074502
22 GDF9interactorCAMSAP_CKK (PF08683, IPR014797, SM01051): Microtubule-binding calmodulin-regulated spectrin-associated
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
AK074502
23 LIMK1oncoproteinLIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
AK074502
24 MAPK6oncoproteinPkinase (PF00069, IPR000719): Protein kinase domainAK074502
25 MAPK8oncoproteinDUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
AK074502
26 MDM2oncoproteinPinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
AK074502
27 PDPK1interactorPkinase (PF00069, IPR000719): Protein kinase domain
PH_3 (PF14593): PH domain
AK074502
28 PPP1CConcoproteinMetallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
AK074502
29 PYCARDsuppressorCARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
AK074502
30 SMAD6interactorMH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
AK074502
31 SMAD7interactorMH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
AK074502
32 TGFBR1oncoproteinActivin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
AK074502
33 TRIB3interactorPkinase (PF00069, IPR000719): Protein kinase domainAK074502
34 TSR1interactorAARP2CN (PF08142, IPR012948, SM00785): AARP2CN (NUC121) domain
RIBIOP_C (PF04950, IPR007034): 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
NUSAP (PF16006, IPR026756): Nucleolar and spindle-associated protein
AK074502
35 XIAPinteractorBIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
AK074502
36 ZNF133parental proteinzf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
AK074502

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