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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ASMTL, BMPR1B (from a repository: Sun Aug 25 14:20:30 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)29
The number (and %) of the onco-proteins5 (17.24 %)
The number (and %) of the tumor suppressors6 (20.69 %)
Total number of binary PPIs (saturation %)79 (19.46 %)
The number (and %) of affected PPIs30 (37.97 %)
The number of possible different fusions5
PPI diameter4
PPI radius2
The average degree of PPI4.483
Assortativity coefficient-0.3804
The network average Clustering coefficient0.479
The number (and %) of a zero Clustering coefficients9 (31.03 %)
The number (and %) of a zero Betweenness Centrality15 (51.72 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions BMPR1A (see 1 fusions); TRAF6 (see 1 fusions); TSC22D1 (see 5 fusions); APP (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BMPR1Bparental protein210.179386.633Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
2 ASMTLparental protein90255.667Maf (PF02545, IPR003697): Maf-like protein
Methyltransf_2 (PF00891, IPR001077): O-methyltransferase
Dimerisation2 (PF16864, IPR031725): Dimerisation domain
3 APPprotein found in more fusions50.500190.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 BAMBIinteractor31.0000BAMBI (PF06211, IPR009345): BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain
DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
5 BMP2suppressor31.0000TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
6 BMP4suppressor31.0000TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
7 BMP7interactor41.0000TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
8 BMPR1Asuppressor160.25777.667Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
9 BMPR2suppressor100.38921.067Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Cadherin_C_2 (PF16492, IPR032455): Cadherin cytoplasmic C-terminal
10 EVA1Cinteractor100Gal_Lectin (PF02140, IPR000922): Galactose binding lectin domain
FAM176 (PF14851): FAM176 family
11 GDF5interactor31.0000TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
12 GDF6interactor31.0000TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
13 HLA-DRB4interactor100DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
14 IGSF1interactor31.0000UEV (PF05743, IPR008883): UEV domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
15 IRF3suppressor40.33327.667IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
16 KRT31interactor2023.000Filament (PF00038, IPR001664): Intermediate filament protein
17 KRT40interactor100Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
18 OTUB1interactor50.7003.500Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
19 PEG10oncoprotein21.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Retrotrans_gag (PF03732, IPR005162): Retrotransposon gag protein
Asp_protease_2 (PF13650): Aspartyl protease
zf-CCHC_5 (PF14787): GAG-polyprotein viral zinc-finger
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
PRIMA1 (PF16101): Proline-rich membrane anchor 1
DUF4939 (PF16297, IPR032549): Domain of unknown function (DUF4939)
20 PNMA1oncoprotein100PNMA (PF14893, IPR026523): PNMA
21 SMAD6interactor70.5717.667MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
22 SMURF1interactor70.66712.567C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
23 SNX6interactor100PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
24 TDO2interactor200Trp_dioxygenase (PF03301, IPR004981): Tryptophan 2,3-dioxygenase
25 TRAF6protein found in more fusions80.42933.033SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
26 TSC22D1suppressor50.8330.500SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
27 USP15oncoprotein80.52451.233UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
28 WDR4interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
29 XIAPinteractor50.50023.800BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)

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