Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RFX7, SLC12A2
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins6 (21.43 %)
The number (and %) of the tumor suppressors1 (3.57 %)
Total number of binary PPIs (saturation %)55 (14.55 %)
The number (and %) of affected PPIs27 (49.09 %)
The number of possible different fusions8
PPI diameter5
PPI radius3
The average degree of PPI3.000
Assortativity coefficient-0.3815
The network average Clustering coefficient0.335
The number (and %) of a zero Clustering coefficients14 (50.00 %)
The number (and %) of a zero Betweenness Centrality18 (64.29 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SLC12A2,RFX7 All fusions
Proteins found in more fusions ILK (see 2 fusions); EGFR (see 2 fusions); SLC12A2 (see 2 fusions); CUL7 (see 2 fusions); LGALS3 (see 2 fusions); COMMD1 (see 1 fusions); MAPK14 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SLC12A2parental protein240.051595.733AA_permease (PF00324, IPR004841): Amino acid permease
AA_permease_N (PF08403, IPR013612): Amino acid permease N-terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SLC12 (PF03522, IPR018491): Solute carrier family 12
2 RFX7parental protein3056.667RFX_DNA_binding (PF02257, IPR003150): RFX DNA-binding domain
Omp_AT (PF11557, IPR021621): Solitary outer membrane autotransporter beta-barrel domain
DUF4111 (PF13427, IPR025184): Domain of unknown function (DUF4111)
3 AK1interactor100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ADK (PF00406, IPR000850): Adenylate kinase
4 ANKRA2interactor30.33364.533Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
5 ATP4Ainteractor200Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
H-K_ATPase_N (PF09040, IPR015127): Gastric H+/K+-ATPase, N terminal domain
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
6 CCDC8interactor50.66745.933Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
7 CDKN2AIPinteractor100XTBD (PF11952, IPR021859): XRN-Two Binding Domain, XTBD
8 COMMD1protein found in more fusions31.0000COMMD1_N (PF17221): COMMD1 N-terminal domain
COMM_domain (PF07258): COMM domain
9 CUL7protein found in more fusions60.50053.933ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
10 EGFRoncoprotein70.33317.000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
11 FAM189A2interactor100CD20 (PF04103, IPR007237): CD20-like family
12 GNG12interactor100G-gamma (PF00631, IPR015898, SM00224): GGL domain
13 ILKsuppressor200Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
14 LGALS3oncoprotein50.6672.000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
15 LGALS8interactor21.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
16 LGALS9interactor31.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
17 LGALS9Cinteractor31.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
18 MAPK14oncoprotein60.5008.600Pkinase (PF00069, IPR000719): Protein kinase domain
19 MCOLN3interactor100PKD_channel (PF08016, IPR013122): Polycystin cation channel
20 NTRK1oncoprotein40.33373.467I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
21 OTUB1interactor2034.133Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
22 RFXANKinteractor200Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
23 SEC13interactor31.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
24 STK39interactor31.0000BASP1 (PF05466, IPR008408): Brain acid soluble protein 1 (BASP1 protein)
FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP)
Pkinase (PF00069, IPR000719): Protein kinase domain
OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
25 TCTN3interactor100DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
26 TMEM17interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
27 TMEM216interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
28 ZACNinteractor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region

B a c k    t o    T o p ⇑