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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SRGAP2C, NEK11 (from a repository: Thu Aug 22 06:28:16 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)7
The number (and %) of the onco-proteins3 (42.86 %)
The number (and %) of the tumor suppressors1 (14.29 %)
Total number of binary PPIs (saturation %)14 (66.67 %)
The number (and %) of affected PPIs5 (35.71 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI2.571
Assortativity coefficient-0.1325
The network average Clustering coefficient0.581
The number (and %) of a zero Clustering coefficients2 (28.57 %)
The number (and %) of a zero Betweenness Centrality5 (71.43 %)


List of the fusions

PPI for parental proteins: NEK11,SRGAP2C All fusions
Proteins found in more fusions HSP90AA1 (see 2 fusions); APP (see 4 fusions); MYC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 NEK11parental protein50.40010.000IncA (PF04156, IPR007285): IncA protein
Pkinase (PF00069, IPR000719): Protein kinase domain
2 SRGAP2Cinteractor000Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
KIP1 (PF07765, IPR011684): KIP1-like protein
DUF2987 (PF11205, IPR021370): Protein of unknown function (DUF2987)
3 APPprotein found in more fusions41.0000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 BLMsuppressor31.0000BDHCT (PF08072, IPR012532): BDHCT (NUC031) domain
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
HRDC (PF00570, IPR002121, SM00341): HRDC domain
RQC (PF09382, IPR018982, SM00956): RQC domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
ALMT (PF11744, IPR020966): Aluminium activated malate transporter
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
BLM_N (PF16202, IPR032437): N-terminal region of Bloom syndrome protein
BDHCT_assoc (PF16204, IPR032439): BDHCT-box associated domain on Bloom syndrome protein
5 HERC2interactor200ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
6 HSP90AA1oncoprotein50.6672.000HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
7 MYConcoprotein41.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region

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