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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins C5orf42, TDG (from a repository: Tue Sep 17 07:53:46 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)41
The number (and %) of the onco-proteins13 (31.71 %)
The number (and %) of the tumor suppressors14 (34.15 %)
Total number of binary PPIs (saturation %)187 (22.80 %)
The number (and %) of affected PPIs39 (20.86 %)
The number of possible different fusions19
PPI diameter5
PPI radius3
The average degree of PPI7.659
Assortativity coefficient-0.3374
The network average Clustering coefficient0.581
The number (and %) of a zero Clustering coefficients4 (9.76 %)
The number (and %) of a zero Betweenness Centrality9 (21.95 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: C5orf42,TDG All fusions
Proteins found in more fusions CREBBP (see 6 fusions); STAT3 (see 2 fusions); RXRA (see 2 fusions); IKZF1 (see 1 fusions); EP300 (see 1 fusions); RARA/PML (see 21 fusions); PCNA (see 1 fusions); SRPK2 (see 1 fusions); VDR (see 2 fusions); SMAD4 (see 3 fusions); PML (see 4 fusions); RARA (see 1 fusions); THRA (see 3 fusions); NR3C1 (see 8 fusions); MYC (see 2 fusions); SERBP1 (see 1 fusions); TP53 (see 3 fusions); PAK1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 C5orf42parental protein40.16782.333Joubert (PF15392, IPR028236): Joubert syndrome-associated
2 TDGparental protein350.185634.208Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein
UDG (PF03167, IPR005122, SM00986): Uracil DNA glycosylase superfamily
3 ARoncoprotein90.6793.580Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
4 CAND1interactor50.33330.996Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
5 CREBBPsuppressor170.46740.735Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
6 CRKoncoprotein21.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
7 DNMT3Bsuppressor31.0000DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase
PWWP (PF00855, IPR000313, SM00293): PWWP domain
8 DTLinteractor40.8330.400WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
9 EP300oncoprotein210.34289.032Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
10 EPM2Ainteractor3010.209CBM_20 (PF00686, IPR002044): Starch binding domain
DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
11 ESR1suppressor140.385166.315Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
12 IKZF1suppressor31.0000Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
13 JUNBoncoprotein41.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
14 MX1interactor41.0000Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
15 MYConcoprotein100.7784.914HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
16 NR3C1protein found in more fusions90.7862.021GCR (PF02155, IPR001409): Glucocorticoid receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
17 NXF1interactor80.33376.085NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
18 PAK1oncoprotein3028.297PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
19 PCNAoncoprotein60.8001.000PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
20 PGRsuppressor60.8000.733Prog_receptor (PF02161, IPR000128): Progesterone receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
21 PMLsuppressor150.41830.117zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
22 RARAoncoprotein70.7331.333zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
23 RNF4interactor110.44461.525Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
24 RXRAoncoprotein80.6193.767zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
25 SERBP1protein found in more fusions50.50034.660HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
26 SKILsuppressor70.7332.979c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
27 SMAD4suppressor90.6075.819MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
28 SRPK2oncoprotein70.200101.928DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
29 STAT3suppressor100.52812.585SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
30 SUMO1interactor110.48914.878Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
31 SUMO2interactor70.7332.091Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
32 SUMO3interactor40.8330.786Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
33 TCF4suppressor41.0000CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
34 THRAsuppressor60.8002.587C1_2 (PF03107, IPR004146): C1 domain
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
35 TP53suppressor190.35990.935DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
36 TP73suppressor80.8571.019P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
37 TUBGCP4interactor100Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
38 UBE2Iinteractor250.283177.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
39 VDRsuppressor70.8001.133zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
40 XPConcoprotein21.0000Rad4 (PF03835, IPR018325): Rad4 transglutaminase-like domain
BHD_1 (PF10403, IPR018326, SM01030): Rad4 beta-hairpin domain 1
BHD_2 (PF10404, IPR018327, SM01031): Rad4 beta-hairpin domain 2
BHD_3 (PF10405, IPR018328, SM01032): Rad4 beta-hairpin domain 3
Macoilin (PF09726, IPR019130): Transmembrane protein
SOG2 (PF10428, IPR019487): RAM signalling pathway protein
Abdominal-A (PF12407, IPR022132): Homeobox protein
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
41 ZSCAN26interactor100C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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