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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CHI3L1, SMTN (from a repository: Mon May 15 07:35:27 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins5 (38.46 %)
The number (and %) of the tumor suppressors3 (23.08 %)
Total number of binary PPIs (saturation %)17 (21.79 %)
The number (and %) of affected PPIs11 (64.71 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI1.846
Assortativity coefficient-0.0580
The network average Clustering coefficient0.157
The number (and %) of a zero Clustering coefficients10 (76.92 %)
The number (and %) of a zero Betweenness Centrality11 (84.62 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CHI3L1,SMTN All fusions
Proteins found in more fusions EWSR1 (see 2 fusions); MYC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CHI3L1parental protein306.000Glyco_hydro_18 (PF00704, IPR001223): Glycosyl hydrolases family 18
2 SMTNparental protein80.03654.000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Peptidase_M3_N (PF08439, IPR013647): Oligopeptidase F
Smoothelin (PF12510, IPR022189): Smoothelin cytoskeleton protein
3 BREoncoprotein100BRE (PF06113, IPR010358): Brain and reproductive organ-expressed protein (BRE)
4 BRMS1suppressor200Dynactin_p62 (PF05502, IPR008603): Dynactin p62 family
Sds3 (PF08598, IPR013907): Sds3-like
5 CD55oncoprotein200Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
HYLS1_C (PF15311, IPR027918): Hydrolethalus syndrome protein 1 C-terminus
6 CDK4oncoprotein21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
7 EWSR1oncoprotein200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
8 KIF7suppressor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
MMR_HSR1_C (PF08438, IPR013646): GTPase of unknown function C-terminal
Nbs1_C (PF08599, IPR013908): DNA damage repair protein Nbs1
XhlA (PF10779, IPR019715): Haemolysin XhlA
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
YlqD (PF11068, IPR021297): YlqD protein
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
9 MOV10interactor100AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
10 MTRF1Linteractor100PCRF (PF03462, IPR005139, SM00937): PCRF domain
RF-1 (PF00472, IPR000352): RF-1 domain
11 MYConcoprotein31.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
12 PTENsuppressor100DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
13 ZWINTinteractor200Zwint (PF15556, IPR029092): ZW10 interactor

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