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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)67
The number (and %) of the onco-proteins22 (32.84 %)
The number (and %) of the tumor suppressors7 (10.45 %)
Total number of binary PPIs (saturation %)286 (12.94 %)
The number (and %) of affected PPIs66 (23.08 %)
The number of possible different fusions21
PPI diameter5
PPI radius3
The average degree of PPI7.552
Assortativity coefficient-0.2812
The network average Clustering coefficient0.540
The number (and %) of a zero Clustering coefficients8 (11.94 %)
The number (and %) of a zero Betweenness Centrality17 (25.37 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SCAPER,PINK1 All fusions
Proteins found in more fusions STAT3 (see 2 fusions); TRAF6 (see 1 fusions); MCL1 (see 2 fusions); KIF11 (see 1 fusions); PRKDC (see 2 fusions); BCL2L1 (see 1 fusions); IMMT (see 4 fusions); HSP90AA1 (see 6 fusions); MAP3K7 (see 7 fusions); HSP90AB1 (see 3 fusions); UBC (see 7 fusions); MARK2 (see 2 fusions); CDC37 (see 2 fusions); TGM2 (see 3 fusions); HSP90AA1/TUBB (see 1 fusions); PINK1 (see 3 fusions); PARK2 (see 1 fusions); VIM (see 1 fusions); TOLLIP (see 1 fusions); BAG2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SCAPERparental protein50.100263.150VIT1 (PF01988, IPR008217): VIT family
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa)
CK1gamma_C (PF12605, IPR022247): Casein kinase 1 gamma C terminal
zf-met (PF12874): Zinc-finger of C2H2 type
SCAPER_N (PF16501, IPR032446): S phase cyclin A-associated protein in the endoplasmic reticulum
2 PINK1parental protein610.0982490.249Pkinase (PF00069, IPR000719): Protein kinase domain
3 AKT1oncoprotein190.294183.629PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
4 APPL1interactor50.16787.080ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
PH (PF00169, IPR001849, SM00233): PH domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
BAR_3 (PF16746): BAR domain of APPL family
5 APPL2interactor2018.484PH (PF00169, IPR001849, SM00233): PH domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
BAR_3 (PF16746): BAR domain of APPL family
6 BAG2protein found in more fusions80.7142.341IncA (PF04156, IPR007285): IncA protein
Mnd1 (PF03962, IPR005647): Mnd1 family
ParD_antitoxin (PF03693, IPR022789): Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH
7 BCL2L1oncoprotein70.5335.061Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
8 BCL2L2oncoprotein21.0000Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
ABATE (PF07336, IPR010852): Putative stress-induced transcription regulator
9 CALM1interactor120.182343.848EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
10 CCNA2oncoprotein40.66718.642Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N
11 CDC37protein found in more fusions100.6119.151CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
12 COPS8interactor40.6671.667CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
13 CRLS1interactor100CDP-OH_P_transf (PF01066, IPR000462): CDP-alcohol phosphatidyltransferase
DUF2162 (PF09930, IPR017199): Predicted transporter (DUF2162)
14 DNM1Linteractor31.0000Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
AAA_16 (PF13191): AAA ATPase domain
15 FBXO7interactor31.0000Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
PI31_Prot_N (PF11566, IPR021625): PI31 proteasome regulator N-terminal
F-box-like (PF12937, IPR001810): F-box-like
16 HECW2interactor200C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
17 HSD17B10interactor70.6196.263adh_short (PF00106, IPR002198): short chain dehydrogenase
18 HSH2Dinteractor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
19 HSP90AA1oncoprotein230.333156.882HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
20 HSP90AB1oncoprotein140.57715.327HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
21 HSPA1Ainteractor110.50917.183HSP70 (PF00012, IPR013126): Hsp70 protein
22 HSPA1Binteractor40.5002.911HSP70 (PF00012, IPR013126): Hsp70 protein
23 HSPA4interactor160.40074.365Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
24 HTRA2suppressor70.6673.167Peptidase_S32 (PF05579, IPR008760): Equine arteritis virus serine endopeptidase S32
PDZ_2 (PF13180, IPR001478): PDZ domain
Trypsin_2 (PF13365): Trypsin-like peptidase domain
25 IMMTprotein found in more fusions60.40016.187Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
26 IRAK1interactor150.36344.261Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
27 IRS4interactor50.8000.536CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
PH_11 (PF15413): Pleckstrin homology domain
28 KIF11protein found in more fusions200Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510)
Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding
29 KRASoncoprotein90.286118.105Ras (PF00071, IPR001806, SM00173): Ras family
30 MAP1Binteractor40.8330.667DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
MAP1B_neuraxin (PF00414, IPR000102): Neuraxin and MAP1B repeat
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
Striatin (PF08232, IPR013258): Striatin family
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
31 MAP1LC3Ainteractor70.5716.119Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
32 MAP3K7oncoprotein70.8001.222Mnd1 (PF03962, IPR005647): Mnd1 family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
33 MAPKAP1interactor31.0000SIN1 (PF05422, IPR008828): Stress-activated map kinase interacting protein 1 (SIN1)
CRIM (PF16978, IPR031567): SAPK-interacting protein 1 (Sin1), middle CRIM domain
SIN1_PH (PF16979, IPR031313): SAPK-interacting protein 1 (Sin1), Pleckstrin-homology
34 MARK2protein found in more fusions31.0000DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
KA1 (PF02149, IPR001772): Kinase associated domain 1
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
35 MCL1oncoprotein70.6003.034Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
36 MZT1interactor100Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
MOZART1 (PF12554, IPR022214): Mitotic-spindle organizing gamma-tubulin ring associated
37 NAE1interactor31.0000ThiF (PF00899, IPR000594): ThiF family
38 PARK2suppressor310.186315.744IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
39 PARK7suppressor90.5007.983DJ-1_PfpI (PF01965, IPR002818): DJ-1/PfpI family
40 PARLinteractor100Rhomboid (PF01694, IPR022764): Rhomboid family
41 PGAM5interactor40.6671.667His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
42 PRKDCprotein found in more fusions51.0000FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
43 PSMC6interactor60.9000.400AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
44 PSMD1interactor90.6118.344PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
HEAT_2 (PF13646): HEAT repeats
45 PSMD2oncoprotein50.60018.635PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
46 PTENsuppressor110.50931.392DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
47 RB1CC1suppressor21.0000Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
DHC (PF09626, IPR018588): Dihaem cytochrome c
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
ATG11 (PF10377, IPR019460): Autophagy-related protein 11
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Jag_N (PF14804, IPR032782): Jag N-terminus
NPBW (PF15180, IPR013297): Neuropeptides B and W
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
48 RHOT1interactor30.6670.333EF_assoc_1 (PF08355, IPR013566): EF hand associated
EF_assoc_2 (PF08356, IPR013567): EF hand associated
Ras (PF00071, IPR001806, SM00173): Ras family
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
49 RHOT2interactor21.0000EF_assoc_1 (PF08355, IPR013566): EF hand associated
EF_assoc_2 (PF08356, IPR013567): EF hand associated
Ras (PF00071, IPR001806, SM00173): Ras family
SPARC_Ca_bdg (PF10591, IPR019577): Secreted protein acidic and rich in cysteine Ca binding region
AAA_16 (PF13191): AAA ATPase domain
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
50 RICTORinteractor50.6002.486RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain
RICTOR_N (PF14664, IPR028267): Rapamycin-insensitive companion of mTOR, N-term
RICTOR_phospho (PF14665, IPR029259): Rapamycin-insensitive companion of mTOR, phosphorylation-site
RICTOR_M (PF14666, IPR029451): Rapamycin-insensitive companion of mTOR, middle domain
RICTOR_V (PF14668, IPR029452): Rapamycin-insensitive companion of mTOR, domain 5
51 SARM1interactor40.8330.500Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Carb_kinase (PF01256, IPR000631): Carbohydrate kinase
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
HEAT_2 (PF13646): HEAT repeats
TIR_2 (PF13676, IPR000157): TIR domain
52 SNCAinteractor150.45167.508Synuclein (PF01387, IPR001058): Synuclein
53 SNCAIPinteractor41.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SNCAIP_SNCA_bd (PF16700, IPR032027): Synphilin-1 alpha-Synuclein-binding domain
54 SOCS4interactor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS (PF12610, IPR001496, SM00253): Suppressor of cytokine signalling
SOCS_box (PF07525, IPR001496): SOCS box
55 STAT3suppressor60.9000.222SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
56 TGM2protein found in more fusions50.33314.883Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
57 TOLLIPprotein found in more fusions60.7002.250C2 (PF00168, IPR000008, SM00239): C2 domain
CUE (PF02845, IPR003892, SM00546): CUE domain
58 TOMM20interactor80.57113.115RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
59 TOMM22interactor60.8670.733Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Tom22 (PF04281, IPR005683): Mitochondrial import receptor subunit Tom22
60 TOMM40interactor100.53314.893Porin_3 (PF01459, IPR027246): Eukaryotic porin
61 TOMM70interactor80.6076.273PBP_GOBP (PF01395, IPR006170, SM00708): PBP/GOBP family
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
NRBF2_MIT (PF17169): MIT domain of nuclear receptor-binding factor 2
62 TRAF6protein found in more fusions190.248168.190SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
63 TUBA1Aoncoprotein110.54515.522Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
64 TUBBprotein found in more fusions130.57718.695Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
65 UBCprotein found in more fusions160.314101.184ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
66 UBE2Minteractor50.6672.286UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
67 VIMsuppressor60.5005.232Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region

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