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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CAMLG, CDCP1 (from a repository: Tue Mar 7 15:45:55 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)18
The number (and %) of the onco-proteins2 (11.11 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)21 (13.73 %)
The number (and %) of affected PPIs16 (76.19 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI1.889
Assortativity coefficient-0.1335
The network average Clustering coefficient0.112
The number (and %) of a zero Clustering coefficients15 (83.33 %)
The number (and %) of a zero Betweenness Centrality16 (88.89 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CAMLG,CDCP1 All fusions
Proteins found in more fusions EGFR (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CAMLGparental protein130.013154.000CAML (PF14963, IPR016719): Calcium signal-modulating cyclophilin ligand
2 CDCP1parental protein306.000CUB (PF00431, IPR000859, SM00042): CUB domain
3 ALBinteractor100Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
4 CLK1interactor200PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
Pkinase (PF00069, IPR000719): Protein kinase domain
5 EGFRoncoprotein200Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
6 EVC2interactor100HBS1_N (PF08938, IPR015033): HBS1 N-terminus
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Histone_HNS (PF00816, IPR001801): H-NS histone family
EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein
7 KCNA2interactor200Ion_trans (PF00520, IPR005821): Ion transport protein
BTB_2 (PF02214, IPR003131): BTB/POZ domain
Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal
8 PPIBinteractor21.0000Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
9 RNF122interactor200zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
10 SDCBPinteractor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
11 TCTN2interactor100DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
12 TCTN3interactor21.0000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
13 TMEM17interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
14 TMEM216interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
15 TMEM67interactor100Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
Tme5_EGF_like (PF09064, IPR015149): Thrombomodulin like fifth domain, EGF-like
Meckelin (PF09773, IPR019170): Meckelin (Transmembrane protein 67)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
16 TMUB1interactor100DUF347 (PF03988, IPR007136): Repeat of Unknown Function (DUF347)
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF4227 (PF14004, IPR025321): Protein of unknown function (DUF4227)
17 TNFRSF13Boncoprotein100TACI-CRD2 (PF09305, IPR015384): TACI, cysteine-rich domain
18 WRBinteractor100CHD5 (PF04420, IPR028945): CHD5-like protein
DUF2868 (PF11067, IPR021296): Protein of unknown function (DUF2868)

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