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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PDE9A, CDCP1 (from a repository: Thu Aug 15 19:01:13 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)24
The number (and %) of the onco-proteins5 (20.83 %)
The number (and %) of the tumor suppressors1 (4.17 %)
Total number of binary PPIs (saturation %)56 (20.29 %)
The number (and %) of affected PPIs24 (42.86 %)
The number of possible different fusions4
PPI diameter4
PPI radius2
The average degree of PPI3.833
Assortativity coefficient-0.3959
The network average Clustering coefficient0.464
The number (and %) of a zero Clustering coefficients9 (37.50 %)
The number (and %) of a zero Betweenness Centrality15 (62.50 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PDE9A,CDCP1 All fusions
Proteins found in more fusions CRY2 (see 3 fusions); PDE9A (see 1 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PDE9Aparental protein210.105385.667PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase
2 CDCP1parental protein3046.500CUB (PF00431, IPR000859, SM00042): CUB domain
3 ALBinteractor100Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
4 BAG3oncoprotein40.6673.000BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
5 C9orf106interactor100NA
6 CLK1interactor40.33353.167PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
Pkinase (PF00069, IPR000719): Protein kinase domain
7 CRY2protein found in more fusions200DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
8 GORASP2interactor21.0000GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
9 KRTAP10-3interactor90.60721.333Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
10 KRTAP10-8interactor80.7622.500Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
11 KRTAP4-2interactor51.0000Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
12 KRTAP9-2interactor61.0000Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
13 LAGE3interactor100Pcc1 (PF09341, IPR015419): Transcription factor Pcc1
14 LMO2oncoprotein31.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
LIM (PF00412, IPR001781, SM00132): LIM domain
15 NAA38interactor100LSM (PF01423, IPR001163): LSM domain
16 NOTCH2NLinteractor90.50031.333EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
17 PHYHIPLinteractor200fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
18 SDCBPinteractor40.16729.333PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
19 SULT1E1interactor21.0000Sulfotransfer_1 (PF00685, IPR000863): Sulfotransferase domain
20 TFAP4oncoprotein100DivIC (PF04977, IPR007060): Septum formation initiator
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF2407 (PF10302, IPR019413): DUF2407 ubiquitin-like domain
21 TRIM32suppressor307.167NHL (PF01436, IPR001258): NHL repeat
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
22 TRPV6oncoprotein41.0000Ion_trans (PF00520, IPR005821): Ion transport protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
23 UNC119interactor21.0000GMP_PDE_delta (PF05351, IPR008015): GMP-PDE, delta subunit
24 UTP23interactor41.0000Fcf1 (PF04900, IPR006984): Fcf1

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