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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins EXOSC7, CDCP1 (from a repository: Sun Jul 28 19:02:02 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)40
The number (and %) of the onco-proteins4 (10.00 %)
The number (and %) of the tumor suppressors4 (10.00 %)
Total number of binary PPIs (saturation %)209 (26.79 %)
The number (and %) of affected PPIs38 (18.18 %)
The number of possible different fusions6
PPI diameter4
PPI radius3
The average degree of PPI9.800
Assortativity coefficient-0.1681
The network average Clustering coefficient0.586
The number (and %) of a zero Clustering coefficients8 (20.00 %)
The number (and %) of a zero Betweenness Centrality8 (20.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CDCP1,EXOSC7 All fusions
Proteins found in more fusions APP/ALB (see 2 fusions); APP (see 5 fusions); RPA1 (see 1 fusions); EXOSC6 (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CDCP1parental protein3010.000CUB (PF00431, IPR000859, SM00042): CUB domain
2 EXOSC7parental protein350.261696.063RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
3 AICDAinteractor140.76910.669APOBEC_N (PF08210, IPR013158): APOBEC-like N-terminal domain
4 ALBprotein found in more fusions2029.899Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
5 APPprotein found in more fusions120.364110.037APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 C1Dinteractor80.6799.554Sas10_Utp3 (PF04000, IPR007146): Sas10/Utp3/C1D family
7 CLK1interactor3010.949PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
Pkinase (PF00069, IPR000719): Protein kinase domain
8 DIS3interactor110.9450.564RNB (PF00773, SM00955): RNB domain
rve (PF00665, IPR001584): Integrase core domain
PIN_4 (PF13638, IPR002716): PIN domain
Rrp44_CSD1 (PF17216): Rrp44-like cold shock domain
Rrp44_S1 (PF17215): S1 domain
9 DIS3Linteractor130.79511.391RNB (PF00773, SM00955): RNB domain
Rrp44_CSD1 (PF17216): Rrp44-like cold shock domain
Rrp44_S1 (PF17215): S1 domain
10 DXOinteractor41.0000RAI1 (PF08652, IPR013961): RAI1 like PD-(D/E)XK nuclease
11 EXOSC1interactor190.64927.125EXOSC1 (PF10447, IPR019495): Exosome component EXOSC1/CSL4
ECR1_N (PF14382, IPR025721): Exosome complex exonuclease RRP4 N-terminal region
12 EXOSC10interactor200.58442.004DNA_pol_A_exo1 (PF01612, IPR002562, SM00474): 3'-5' exonuclease
HRDC (PF00570, IPR002121, SM00341): HRDC domain
PMC2NT (PF08066, IPR012588): PMC2NT (NUC016) domain
Sec62 (PF03839, IPR004728): Translocation protein Sec62
13 EXOSC2interactor140.8575.542EXOSC1 (PF10447, IPR019495): Exosome component EXOSC1/CSL4
ECR1_N (PF14382, IPR025721): Exosome complex exonuclease RRP4 N-terminal region
KH_6 (PF15985, IPR004088): KH domain
14 EXOSC3interactor210.63232.662KH_6 (PF15985, IPR004088): KH domain
15 EXOSC4interactor190.66725.833RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
16 EXOSC5interactor170.7508.811RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
17 EXOSC6protein found in more fusions170.7839.148RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
18 EXOSC8interactor240.53456.216RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
19 EXOSC9interactor160.7677.375RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
20 GDI1interactor100GDI (PF00996, IPR018203): GDP dissociation inhibitor
21 GIGYF2interactor30.6670.500DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
GYF (PF02213, IPR003169, SM00444): GYF domain
Macoilin (PF09726, IPR019130): Transmembrane protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
DUF3801 (PF12687, IPR024234): Protein of unknown function (DUF3801)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
AAA_23 (PF13476): AAA domain
ARGLU (PF15346): Arginine and glutamate-rich 1
PRTase_3 (PF15610, IPR028944): PRTase ComF-like
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
22 HBS1Linteractor100.8674.541HBS1_N (PF08938, IPR015033): HBS1 N-terminus
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
23 HDAC1suppressor31.0000FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
24 HECW2interactor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
25 IFI16suppressor110.582108.303HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
26 IP6K1interactor2074.949IPK (PF03770, IPR005522): Inositol polyphosphate kinase
SIN1 (PF05422, IPR008828): Stress-activated map kinase interacting protein 1 (SIN1)
27 MPHOSPH6interactor120.7588.219MPP6 (PF10175, IPR019324): M-phase phosphoprotein 6
28 MRPL50interactor100Ribosomal_L50 (PF10501, IPR018305): Ribosomal subunit 39S
29 MZT1interactor21.0000Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
MOZART1 (PF12554, IPR022214): Mitotic-spindle organizing gamma-tubulin ring associated
30 RBM7interactor100.8672.065RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
31 RPA1suppressor100.7223.869Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
32 RPA2oncoprotein90.6947.668RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
33 RPA3interactor80.9520.250Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
34 SDCBPinteractor2035.152PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
35 SKIV2L2interactor180.51048.561DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DSHCT (PF08148, IPR012961, SM01142): DSHCT (NUC185) domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
rRNA_proc-arch (PF13234, IPR025696): rRNA-processing arch domain
36 TP53suppressor110.37828.887DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
37 TSNAXinteractor21.0000Translin (PF01997, IPR002848): Translin family
38 USP30interactor100UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
39 ZCCHC8interactor90.6947.248Herpes_BLRF2 (PF05812, IPR008642): Herpesvirus BLRF2 protein
PSP (PF04046, IPR006568, SM00581): PSP
zf-CCHC (PF00098, IPR001878): Zinc knuckle
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
40 ZFC3H1interactor50.7001.947Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
LMBR1 (PF04791, IPR006876): LMBR1-like membrane protein
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
DUF2277 (PF10041, IPR018735): Uncharacterized conserved protein (DUF2277)
zf-C3H1 (PF10650, IPR019607, SM00356): Putative zinc-finger domain
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
FNIP_N (PF14636, IPR028084): Folliculin-interacting protein N-terminus

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