Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins YTHDC2, ASCC1 (from a repository: Mon Aug 19 21:14:12 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)53
The number (and %) of the onco-proteins17 (32.08 %)
The number (and %) of the tumor suppressors3 (5.66 %)
Total number of binary PPIs (saturation %)205 (14.88 %)
The number (and %) of affected PPIs51 (24.88 %)
The number of possible different fusions11
PPI diameter5
PPI radius3
The average degree of PPI6.830
Assortativity coefficient-0.3166
The network average Clustering coefficient0.338
The number (and %) of a zero Clustering coefficients13 (24.53 %)
The number (and %) of a zero Betweenness Centrality14 (26.42 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ASCC1,YTHDC2 All fusions
Proteins found in more fusions COPS5 (see 1 fusions); CUL3 (see 1 fusions); DCTN1 (see 2 fusions); EP300 (see 1 fusions); SRPK2 (see 1 fusions); NCOA1 (see 2 fusions); AURKA (see 1 fusions); NCOA6 (see 1 fusions); HSP90AA1 (see 6 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ASCC1parental protein290.0591193.374AKAP7_NLS (PF10469, IPR019510): AKAP7 2'5' RNA ligase-like domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
2 YTHDC2parental protein220.225416.144DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
R3H (PF01424, IPR001374, SM00393): R3H domain
YTH (PF04146, IPR007275): YT521-B-like domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_23 (PF13476): AAA domain
3 ALKBH3interactor50.50012.4822OG-FeII_Oxy_2 (PF13532, IPR027450): 2OG-Fe(II) oxygenase superfamily
4 ASCC2interactor70.42944.800CUE (PF02845, IPR003892, SM00546): CUE domain
BLOC1S3 (PF15753, IPR017245): Biogenesis of lysosome-related organelles complex 1 subunit 3
5 ASCC3interactor90.194100.026DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
PhoH (PF02562, IPR003714): PhoH-like protein
Sec63 (PF02889, IPR004179, SM00973): Sec63 Brl domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
6 AURKAoncoprotein80.28646.805Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
7 C3interactor100A2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
ANATO (PF01821, IPR000020, SM00104): Anaphylotoxin-like domain
NTR (PF01759, IPR018933, SM00206): UNC-6/NTR/C345C module
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
8 CALML5interactor30.33318.697EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
9 CAND1interactor140.51332.521Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
10 CBX8interactor70.26744.660Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
RBR (PF17208): RNA binding Region
CBX7_C (PF17218): CBX family C-terminal motif
11 CC2D2Ainteractor30.3336.759C2 (PF00168, IPR000008, SM00239): C2 domain
ZnuA (PF01297, IPR006127): Zinc-uptake complex component A periplasmic
DUF4240 (PF14024, IPR025334): Protein of unknown function (DUF4240)
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
CC2D2AN-C2 (PF15625, IPR028928): CC2D2A N-terminal C2 domain
12 CCDC8interactor80.38116.924Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
13 COPS5protein found in more fusions140.333110.723JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
14 CPA4interactor100Peptidase_M14 (PF00246, IPR000834, SM00631): Zinc carboxypeptidase
Propep_M14 (PF02244, IPR003146): Carboxypeptidase activation peptide
15 CSNK2A2interactor70.33371.184Pkinase (PF00069, IPR000719): Protein kinase domain
16 CUL3protein found in more fusions150.48447.794Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
17 DCTN1protein found in more fusions60.60016.583Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
FlgN (PF05130, IPR007809): FlgN protein
HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Dynactin (PF12455, IPR022157): Dynein associated protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
18 ELAVL1oncoprotein140.295151.245RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
19 EP300oncoprotein100.38961.135Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
20 ESR1suppressor110.37868.883Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
21 FBXW11interactor90.39328.192WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
22 FGBinteractor21.0000Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
23 FGFR1OPoncoprotein31.0000FOP_dimer (PF09398, IPR018993): FOP N terminal dimerisation domain
24 FGGinteractor31.0000Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
25 GSTO1interactor21.0000GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
26 HNRNPUinteractor130.37260.984CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
27 HSP90AA1oncoprotein140.43646.854HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
28 IFI16suppressor60.33314.288HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
29 IGHG1oncoprotein100C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
30 IGHG2oncoprotein100C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
31 IGKConcoprotein100DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
32 IGLL5interactor206.480C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
33 IRAK1interactor90.42920.217Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
34 IRF4suppressor30.3336.543IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
35 NCOA1oncoprotein80.52420.060DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
36 NCOA6oncoprotein51.0000DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719)
Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1
Presenilin (PF01080, IPR001108): Presenilin
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
Nucleic_acid_bd (PF13820, IPR032715): Putative nucleic acid-binding region
NST1 (PF13945, IPR025279): Salt tolerance down-regulator
37 NIFKinteractor70.38114.078RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
hNIFK_binding (PF12196, IPR021043): FHA Ki67 binding domain of hNIFK
38 NTRK1oncoprotein200.269238.024I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
39 PNMA2interactor2011.078PNMA (PF14893, IPR026523): PNMA
40 SERPINB3oncoprotein204.984Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
41 SIRT7interactor80.28627.365DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
42 SKA1interactor30.33325.625SKA1 (PF07160, IPR009829): Spindle and kinetochore-associated protein 1
43 SMC6interactor306.480SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
44 SNW1protein found in more fusions150.38573.552SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
45 SOD1interactor200Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
46 SRPK2oncoprotein80.33330.807DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
47 TARDBPinteractor100.7506.614RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
48 TRAF2interactor70.26763.312MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
49 TRIP4interactor80.46422.682ASCH (PF04266, IPR007374, SM01022): ASCH domain
UxaC (PF02614, IPR003766): Glucuronate isomerase
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
50 UFSP2interactor100Peptidase_C78 (PF07910, IPR012462): Peptidase family C78
51 USP42interactor100TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
AP3D1 (PF06375): AP-3 complex subunit delta-1
52 XPO1interactor120.303125.044CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
53 ZBTB38interactor100BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_7 (PF15269): Zinc-finger
zf-C2H2_8 (PF15909, IPR031799): C2H2-type zinc ribbon

B a c k    t o    T o p ⇑