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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SHMT1, SMCR8 (from a repository: Mon Jul 22 18:11:04 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)50
The number (and %) of the onco-proteins11 (22.00 %)
The number (and %) of the tumor suppressors7 (14.00 %)
Total number of binary PPIs (saturation %)170 (13.88 %)
The number (and %) of affected PPIs49 (28.82 %)
The number of possible different fusions10
PPI diameter5
PPI radius3
The average degree of PPI6.200
Assortativity coefficient-0.3463
The network average Clustering coefficient0.394
The number (and %) of a zero Clustering coefficients15 (30.00 %)
The number (and %) of a zero Betweenness Centrality14 (28.00 %)


List of the fusions

PPI for parental proteins: SHMT1,SMCR8 All fusions
Proteins found in more fusions IMPDH2 (see 1 fusions); APEH (see 1 fusions); SMAD4 (see 3 fusions); TSN (see 1 fusions); ATP6V1C1 (see 3 fusions); MAPK9 (see 3 fusions); ITPA (see 1 fusions); STAT1 (see 1 fusions); CTTN (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 SHMT1parental protein420.0961456.021SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
2 SMCR8parental protein70.095226.172Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport
3 APEHoncoprotein100.63910.658Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
4 ARFIP1interactor60.46730.728Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
5 ATIConcoprotein30.6673.891AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
6 ATP6V1C1protein found in more fusions130.62113.655V-ATPase_C (PF03223, IPR004907): V-ATPase subunit C
7 C18orf25interactor100RNF111_N (PF15303, IPR029306): E3 ubiquitin-protein ligase Arkadia N-terminus
8 CARSoncoprotein90.47222.382tRNA-synt_1e (PF01406, IPR024909): tRNA synthetases class I (C) catalytic domain
9 CDC16interactor100Dynein_light (PF01221, IPR001372): Dynein light chain type 1
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
SRP_TPR_like (PF17004, IPR031545): Putative TPR-like repeat
10 CRYABoncoprotein309.422Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
11 CTTNoncoprotein110.66713.273FadA (PF09403, IPR018543): Adhesion protein FadA
HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
12 DEDDinteractor200DED (PF01335, IPR001875, SM00031): Death effector domain
13 DLEU1suppressor100DD_K (PF12121, IPR022731): Dermaseptin
14 FAM129Binteractor80.57136.553PH (PF00169, IPR001849, SM00233): PH domain
15 GARSinteractor80.57115.413HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
16 GSPT2interactor70.9050.536GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
17 GTF2F2interactor203.891TFIIF_beta (PF02270, IPR003196): Transcription initiation factor IIF, beta subunit
18 HARSinteractor60.53314.146HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
Sugarporin_N (PF11471, IPR021570): Maltoporin periplasmic N-terminal extension
tRNA-synt_His (PF13393): Histidyl-tRNA synthetase
19 HIST1H4Ainteractor50.7003.598CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
20 HSPA1Linteractor100HSP70 (PF00012, IPR013126): Hsp70 protein
21 HSPE1interactor40.5003.306Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
22 IDEinteractor100.62215.662Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
23 IMPDH2protein found in more fusions60.50034.194IMPDH (PF00478, IPR001093): IMP dehydrogenase / GMP reductase domain
24 ITPAprotein found in more fusions31.0000Ham1p_like (PF01725, IPR002637): Ham1 family
25 MAPK9suppressor200Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
26 MCATinteractor100Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain
27 MMS19interactor40.50012.496DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
28 NTRK1oncoprotein210.147361.188I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
29 PAICSinteractor60.40013.666AIRC (PF00731, IPR000031, SM01001): AIR carboxylase
SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
30 PAWRsuppressor110.61810.593ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
31 PBDC1interactor100Polysacc_synt_4 (PF04669, IPR021148): Polysaccharide biosynthesis
32 PGK2interactor21.0000PGK (PF00162, IPR001576): Phosphoglycerate kinase
33 PIM1oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
34 PPATinteractor60.46741.585Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
GATase_6 (PF13522): Glutamine amidotransferase domain
35 PRRC1interactor30.6670.667NTPase_I-T (PF01931, IPR026533): Protein of unknown function DUF84
36 PRSS23interactor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
37 RB1CC1suppressor100Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
DHC (PF09626, IPR018588): Dihaem cytochrome c
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
ATG11 (PF10377, IPR019460): Autophagy-related protein 11
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Jag_N (PF14804, IPR032782): Jag N-terminus
NPBW (PF15180, IPR013297): Neuropeptides B and W
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
38 SHMT2interactor140.41868.341SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
39 SMAD4suppressor40.33365.522MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
40 SNX2interactor140.44091.727PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
41 SNX6interactor120.51548.460PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
42 STAT1suppressor130.66716.481SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
43 STXBP1interactor203.891Sec1 (PF00995, IPR001619): Sec1 family
44 SULT1A3interactor100Sulfotransfer_1 (PF00685, IPR000863): Sulfotransferase domain
45 TMEM17interactor40.16732.195Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
46 TSNprotein found in more fusions70.9330.333Translin (PF01997, IPR002848): Translin family
47 TTC1interactor70.5247.333TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
48 VPS29interactor80.8571.400Metallophos_2 (PF12850, IPR024654): Calcineurin-like phosphoesterase superfamily domain
49 XPO5suppressor60.40036.732IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
50 ZC3H4interactor203.891API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
Baculo_PP31 (PF05311, IPR007975): Baculovirus 33KDa late protein (PP31)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381)
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
Torus (PF16131, IPR032297): Torus domain

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