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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MTMR14, B2M (from a repository: Mon Oct 8 17:03:13 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)30
The number (and %) of the onco-proteins13 (43.33 %)
The number (and %) of the tumor suppressors1 (3.33 %)
Total number of binary PPIs (saturation %)79 (18.16 %)
The number (and %) of affected PPIs29 (36.71 %)
The number of possible different fusions9
PPI diameter5
PPI radius3
The average degree of PPI4.467
Assortativity coefficient-0.1543
The network average Clustering coefficient0.457
The number (and %) of a zero Clustering coefficients7 (23.33 %)
The number (and %) of a zero Betweenness Centrality9 (30.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: B2M,MTMR14 All fusions
Proteins found in more fusions ERBB3 (see 2 fusions); APP (see 4 fusions); CALR (see 6 fusions); HLA-B (see 2 fusions); A2M (see 2 fusions); GRB2 (see 1 fusions); B2M (see 10 fusions); HLA-B/HLA-C (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 B2Mparental protein240.123500.628C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
2 MTMR14parental protein50.10080.806Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
Y_phosphatase3 (PF13350, IPR026893): Tyrosine phosphatase family
3 A2Mprotein found in more fusions50.33320.294A2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
MP (PF01107, IPR028919): Viral movement protein (MP)
SVA (PF05326, IPR007990): Seminal vesicle autoantigen (SVA)
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
4 APPprotein found in more fusions80.048134.202APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 BAG6interactor40.6672.000DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
6 CALRoncoprotein80.42944.161Calreticulin (PF00262, IPR001580): Calreticulin family
DDHD (PF02862, IPR004177, SM01127): DDHD domain
7 CD1Binteractor21.0000C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
MLANA (PF14991, IPR029242): Protein melan-A
MHC_I_3 (PF16497, IPR011161): MHC-I family domain
8 CD1Dinteractor21.0000Kelch_2 (PF07646, IPR011498): Kelch motif
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
MHC_I_3 (PF16497, IPR011161): MHC-I family domain
9 CRYABoncoprotein40.33314.822Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
10 CXCR4interactor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
COX2_TM (PF02790, IPR011759): Cytochrome C oxidase subunit II, transmembrane domain
CXCR4_N (PF12109, IPR022726): CXCR4 Chemokine receptor N terminal
11 ERBB3oncoprotein50.6674.308Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
12 FAM90A1interactor21.0000zf-CCHC_6 (PF15288): Zinc knuckle
13 GRB2oncoprotein50.33351.011SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
14 HFEoncoprotein100DUF912 (PF06024, IPR009261): Nucleopolyhedrovirus protein of unknown function (DUF912)
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
15 HLA-Aoncoprotein110.40034.296DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
16 HLA-Boncoprotein70.6005.333MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
17 HLA-Cprotein found in more fusions70.7334.108Marek_A (PF02124, IPR001038): Marek's disease glycoprotein A
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
18 HLA-Einteractor70.6198.382MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
AA_permease_C (PF13906, IPR029485): C-terminus of AA_permease
19 HLA-Finteractor31.0000MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
Ig_3 (PF13927): Immunoglobulin domain
20 HSPB2interactor40.6670.667Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
21 MAP1Sinteractor100Lactamase_B_6 (PF16661, IPR001279): Metallo-beta-lactamase superfamily domain
22 MAPK15interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
23 MIA3interactor100bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
IncA (PF04156, IPR007285): IncA protein
NPIP (PF06409): Nuclear pore complex interacting protein (NPIP)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
24 PRSS23interactor2010.822Trypsin (PF00089, IPR001254, SM00020): Trypsin
25 PTTG1oncoprotein40.33348.259Securin (PF04856, IPR006940): Securin sister-chromatid separation inhibitor
26 TAP1oncoprotein50.9000.333ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
27 TAP2oncoprotein70.52443.102ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
28 TAPBPinteractor50.9000.333C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
29 TP53BP2suppressor2014.539ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Erp_C (PF06780, IPR009618): Erp protein C-terminus
SlyX (PF04102, IPR007236): SlyX
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
30 XPO1interactor2015.593CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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