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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MTMR14, HSPE1-MOB4 (from a repository: Mon Oct 14 18:26:14 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)7
The number (and %) of the onco-proteins1 (14.29 %)
The number (and %) of the tumor suppressors1 (14.29 %)
Total number of binary PPIs (saturation %)7 (33.33 %)
The number (and %) of affected PPIs5 (71.43 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI1.714
Assortativity coefficient-0.4472
The network average Clustering coefficient0.300
The number (and %) of a zero Clustering coefficients4 (57.14 %)
The number (and %) of a zero Betweenness Centrality6 (85.71 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MTMR14,HSPE1-MOB4 All fusions
Proteins found in more fusions APP (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MTMR14parental protein50.10018.000Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
Y_phosphatase3 (PF13350, IPR026893): Tyrosine phosphatase family
2 HSPE1-MOB4interactor000Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
3 APPprotein found in more fusions31.0000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 FAM90A1interactor21.0000zf-CCHC_6 (PF15288): Zinc knuckle
5 MIA3interactor100bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
IncA (PF04156, IPR007285): IncA protein
NPIP (PF06409): Nuclear pore complex interacting protein (NPIP)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
6 TP53BP2suppressor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Erp_C (PF06780, IPR009618): Erp protein C-terminus
SlyX (PF04102, IPR007236): SlyX
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
7 XPO1interactor100CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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