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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CGN, SFTPC (from a repository: Wed Dec 7 16:43:06 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)35
The number (and %) of the onco-proteins8 (22.86 %)
The number (and %) of the tumor suppressors4 (11.43 %)
Total number of binary PPIs (saturation %)122 (20.50 %)
The number (and %) of affected PPIs34 (27.87 %)
The number of possible different fusions6
PPI diameter4
PPI radius3
The average degree of PPI6.229
Assortativity coefficient-0.1134
The network average Clustering coefficient0.522
The number (and %) of a zero Clustering coefficients5 (14.29 %)
The number (and %) of a zero Betweenness Centrality8 (22.86 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SFTPC,CGN All fusions
Proteins found in more fusions VCP (see 4 fusions); NEDD4 (see 1 fusions); SFTPC (see 1 fusions); WWP1 (see 1 fusions); YWHAG (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SFTPCparental protein150.099417.873BRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain
SP_C-Propep (PF08999, IPR015091): Surfactant protein C, N terminal propeptide
2 CGNparental protein190.281187.824DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Filament (PF00038, IPR001664): Intermediate filament protein
Laminin_II (PF06009, IPR010307): Laminin Domain II
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
DUF4559 (PF15112, IPR027897): Domain of unknown function (DUF4559)
Leu_zip (PF15294): Leucine zipper
3 CAPZA2interactor80.7505.533F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
4 CCDC8interactor110.48941.897Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
5 CXCL9interactor21.0000MRP-S27 (PF10037, IPR019266): Mitochondrial 28S ribosomal protein S27
IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
SNARE (PF05739, IPR000727, SM00397): SNARE domain
VasL (PF12486, IPR021069): Type VI secretion system, EvfB, or VasL
6 DBN1oncoprotein61.0000Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
7 DNAJB9interactor31.0000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
8 DNAJC10interactor31.0000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
9 HSPA5oncoprotein110.289164.672HSP70 (PF00012, IPR013126): Hsp70 protein
10 IQGAP1interactor120.485108.514CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
11 LATS1suppressor50.40035.232Cas_Cas6 (PF01881, IPR010156): CRISPR associated protein Cas6
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
12 LATS2suppressor70.53325.539Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
13 LNX1interactor5025.065PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
14 MYH11oncoprotein30.6670.667IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
15 MYO18Ainteractor70.8102.333Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
16 MYO5Cinteractor70.8571.400DIL (PF01843, IPR018444, SM01132): DIL domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Pilus_CpaD (PF09476, IPR019027): Pilus biogenesis CpaD protein (pilus_cpaD)
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
YtxH (PF12732, IPR024623): YtxH-like protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
17 NEDD4suppressor40.33334.785Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
18 OBSL1interactor110.42264.047BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
19 PQBP1interactor3018.134WW (PF00397, IPR001202, SM00456): WW domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
20 SEC22Ainteractor30.6671.000Longin (PF13774, IPR010908): Regulated-SNARE-like domain
21 SEC61Ginteractor100SecE (PF00584, IPR001901): SecE/Sec61-gamma subunits of protein translocation complex
22 SFNsuppressor60.40020.67114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
23 SIRT7interactor50.6007.318DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
24 SYNE4interactor30.6671.000KASH (PF10541, IPR012315): Nuclear envelope localisation domain
25 SYNPOinteractor70.7623.400Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin)
26 TJP1interactor60.6005.117DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
ZU5 (PF00791, IPR000906, SM00218): ZU5 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
RPOL_N (PF14700, IPR029262): DNA-directed RNA polymerase N-terminal
27 TJP2oncoprotein110.36437.459PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
28 TMEM67interactor21.0000Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
Tme5_EGF_like (PF09064, IPR015149): Thrombomodulin like fifth domain, EGF-like
Meckelin (PF09773, IPR019170): Meckelin (Transmembrane protein 67)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
29 TMEM79interactor31.0000MAPEG (PF01124, IPR001129): MAPEG family
30 VCPprotein found in more fusions130.288209.557AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
31 WWP1oncoprotein4020.468C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
32 WWP2interactor200WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
33 YWHABinteractor60.53310.85614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
34 YWHAEoncoprotein70.57118.41814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
35 YWHAGprotein found in more fusions100.41729.22114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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