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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)46
The number (and %) of the onco-proteins11 (23.91 %)
The number (and %) of the tumor suppressors8 (17.39 %)
Total number of binary PPIs (saturation %)135 (13.04 %)
The number (and %) of affected PPIs45 (33.33 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI5.217
Assortativity coefficient-0.4793
The network average Clustering coefficient0.541
The number (and %) of a zero Clustering coefficients10 (21.74 %)
The number (and %) of a zero Betweenness Centrality19 (41.30 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MPP5,ESRRG All fusions
Proteins found in more fusions AMOTL2 (see 1 fusions); APP (see 4 fusions); NCOA1 (see 2 fusions); ZNF451 (see 1 fusions); PSMC5 (see 2 fusions); SP1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MPP5parental protein170.316243.596L27 (PF02828, IPR014775, SM00569): L27 domain
L27_N (PF09060, IPR015145): L27_N
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
2 ESRRGparental protein280.0681076.974zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
3 AMOToncoprotein160.410322.520FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP)
Gastrin (PF00918, IPR001651, SM00029): Gastrin/cholecystokinin family
DUF2162 (PF09930, IPR017199): Predicted transporter (DUF2162)
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
4 AMOTL1interactor60.8671.669NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Presenilin (PF01080, IPR001108): Presenilin
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
5 AMOTL2protein found in more fusions80.9520.286HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
6 APPprotein found in more fusions140.154502.984APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
7 ARHGAP17interactor50.60026.618BAR (PF03114, IPR004148, SM00721): BAR domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
8 ARHGEF15interactor100Med14 (PF08638, IPR013947): Mediator complex subunit MED14
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
9 CEP128interactor50.50052.923DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
10 DEUP1suppressor40.33361.468APG6 (PF04111, IPR007243): Autophagy protein Apg6
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
CEP63 (PF17045, IPR031470): Centrosomal protein of 63 kDa
11 DNMT3Linteractor100CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
12 DUTinteractor21.0000dUTPase (PF00692, IPR008180): dUTPase
13 EBPinteractor21.0000Phage_holin_3_6 (PF07332, IPR009937): Putative Actinobacterial Holin-X, holin superfamily III
EBP (PF05241, IPR007905): Emopamil binding protein
14 ESRRAoncoprotein110.27361.478zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
15 HGSinteractor21.0000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
16 KIFC3oncoprotein40.6673.000Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
17 LATS1suppressor90.55690.426Cas_Cas6 (PF01881, IPR010156): CRISPR associated protein Cas6
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
18 LATS2suppressor130.500108.608Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
19 LIN7Ainteractor50.60037.056DUF932 (PF06067, IPR026325): Domain of unknown function (DUF932)
L27 (PF02828, IPR014775, SM00569): L27 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
20 LIN7Cinteractor70.9520.286His_Phos_2 (PF00328, IPR000560): Histidine phosphatase superfamily (branch 2)
L27 (PF02828, IPR014775, SM00569): L27 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
21 MEOX2interactor21.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
22 MPDZinteractor80.6797.069L27_2 (PF09045, IPR015132): L27_2
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
MPDZ_u10 (PF16667, IPR032078): Unstructured region 10 on multiple PDZ protein
23 NCOA1oncoprotein41.0000DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
24 NINLinteractor40.8330.833PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat
TBCA (PF02970, IPR004226): Tubulin binding cofactor A
DUF2389 (PF09493, IPR012663): Tryptophan-rich protein (DUF2389)
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
FAM184 (PF15665): Family with sequence similarity 184, A and B
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
25 NR0B1interactor31.0000zf-C4_ClpX (PF06689, IPR010603, SM00994): ClpX C4-type zinc finger
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
NR_Repeat (PF14046, IPR025900): Nuclear receptor repeat
26 NR0B2suppressor21.0000Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
27 NRIP1oncoprotein50.60025.920ALMT (PF11744, IPR020966): Aluminium activated malate transporter
NRIP1_repr_1 (PF15687, IPR031405): Nuclear receptor-interacting protein 1 repression 1
NRIP1_repr_2 (PF15688, IPR031406): Nuclear receptor-interacting protein 1 repression 2
NRIP1_repr_3 (PF15689, IPR031407): Nuclear receptor-interacting protein 1 repression 3
NRIP1_repr_4 (PF15690, IPR031408): Nuclear receptor-interacting protein 1 repression 4
28 NUP160interactor2094.517Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
29 PARD6Ainteractor30.66716.879PB1 (PF00564, IPR000270, SM00666): PB1 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
30 PARK2suppressor70.400176.634IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
31 PATJoncoprotein90.6397.867L27_2 (PF09045, IPR015132): L27_2
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
MPDZ_u10 (PF16667, IPR032078): Unstructured region 10 on multiple PDZ protein
32 PNRC1interactor100PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
33 PNRC2interactor21.0000PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
34 PPARGC1Ainteractor40.8330.667Pap_E4 (PF02711, IPR003861): E4 protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RSRP (PF17069): Arginine/Serine-Rich protein 1
35 PROX1suppressor21.0000GET2 (PF08690, IPR028143): GET complex subunit GET2
NifQ (PF04891, IPR006975): NifQ
HPD (PF05044, IPR023082): Homeo-prospero domain
PP_kinase_N (PF13089, IPR025198): Polyphosphate kinase N-terminal domain
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
36 PSMC5protein found in more fusions50.8333.667AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
37 SHTN1interactor200Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
VIT1 (PF01988, IPR008217): VIT family
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
DUF3484 (PF11983, IPR021873): Membrane-attachment and polymerisation-promoting switch
Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
38 SOCS4interactor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS (PF12610, IPR001496, SM00253): Suppressor of cytokine signalling
SOCS_box (PF07525, IPR001496): SOCS box
39 SP1protein found in more fusions41.0000zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
40 SRA1interactor100SRA1 (PF07304, IPR009917): Steroid receptor RNA activator (SRA1)
41 SRPK1interactor30.33359.384FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
42 SUMO1P1interactor200NA
43 TLE1interactor200TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
44 WWOXsuppressor60.53341.386adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain
45 YAP1suppressor90.7783.286Bindin (PF02084, IPR000775): Bindin
WW (PF00397, IPR001202, SM00456): WW domain
GspL_C (PF12693, IPR025691): GspL periplasmic domain
FAM181 (PF15238, IPR029359): FAM181
46 ZNF451protein found in more fusions200zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-met (PF12874): Zinc-finger of C2H2 type
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Cys_rich_KTR (PF14205, IPR025957): Cysteine-rich KTR
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain

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