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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)79
The number (and %) of the onco-proteins27 (34.18 %)
The number (and %) of the tumor suppressors13 (16.46 %)
Total number of binary PPIs (saturation %)527 (17.10 %)
The number (and %) of affected PPIs78 (14.80 %)
The number of possible different fusions15
PPI diameter4
PPI radius2
The average degree of PPI12.658
Assortativity coefficient-0.2442
The network average Clustering coefficient0.633
The number (and %) of a zero Clustering coefficients5 (6.33 %)
The number (and %) of a zero Betweenness Centrality16 (20.25 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions PTPN11 (see 1 fusions); CUL4A (see 4 fusions); FOXO1 (see 2 fusions); SFN (see 1 fusions); DCAF1 (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); MDM4 (see 2 fusions); UBE2D2 (see 2 fusions); YWHAZ (see 3 fusions); FOS (see 4 fusions); COPS5 (see 1 fusions); DDB1 (see 2 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SLIT3parental protein201.500EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Metallothi_Euk2 (PF12809): Eukaryotic metallothionein
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
2 RFWD2parental protein760.1503143.340Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
IncA (PF04156, IPR007285): IncA protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
WD40_like (PF17005, IPR031544): WD40-like domain
3 ATF6interactor31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DUF2749 (PF10907, IPR024475): Protein of unknown function (DUF2749)
4 BTBD2interactor90.8891.474BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PHR (PF08005, IPR012983): PHR domain
5 CAPN1interactor2042.992Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
6 CCT2interactor130.8213.863Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
7 CCT3interactor110.9450.668Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
8 CCT4interactor130.8213.863Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
9 CCT5interactor120.8483.059Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
10 CCT6Ainteractor110.9450.668Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
11 CCT7interactor110.9450.668Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
12 CCT8interactor130.8213.863Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
13 CDKN1Bsuppressor140.52718.594CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH
14 COPS2suppressor220.68825.109YozE_SAM_like (PF06855, IPR023089): YozE SAM-like fold
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2087 (PF09860, IPR018656): Uncharacterized protein conserved in bacteria (DUF2087)
PCI (PF01399, IPR000717, SM00088): PCI domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
15 COPS3interactor250.66025.004RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
PCI (PF01399, IPR000717, SM00088): PCI domain
16 COPS4interactor270.59855.595DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
PCI (PF01399, IPR000717, SM00088): PCI domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
17 COPS5protein found in more fusions400.398209.545JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
18 COPS6interactor310.501111.611DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
19 COPS7Ainteractor220.76610.472PCI (PF01399, IPR000717, SM00088): PCI domain
20 COPS7Binteractor200.75811.049PCI (PF01399, IPR000717, SM00088): PCI domain
21 COPS8interactor200.8424.474CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
22 CRTC2oncoprotein30.6671.115TORC_N (PF12884, IPR024783): Transducer of regulated CREB activity, N terminus
TORC_M (PF12885, IPR024784): Transducer of regulated CREB activity middle domain
TORC_C (PF12886, IPR024785): Transducer of regulated CREB activity, C terminus
23 CUL1suppressor270.44679.905Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
24 CUL2suppressor180.66018.118Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
25 CUL3protein found in more fusions360.365197.804Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
26 CUL4Aprotein found in more fusions280.58750.084Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
27 CUL4Boncoprotein250.63034.752Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
28 DCAF1protein found in more fusions170.80010.571DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
LisH (PF08513, IPR013720, SM00667): LisH
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
29 DCAF11interactor111.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
30 DDA1interactor190.7789.665DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
31 DDB1protein found in more fusions240.69622.403CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
32 DDB2suppressor240.56152.403WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
33 DET1interactor120.37928.305Det1 (PF09737, IPR019138): De-etiolated protein 1 Det1
34 DMC1interactor200Rad51 (PF08423, IPR013632): Rad51
HHH_5 (PF14520): Helix-hairpin-helix domain
35 ELAVL1oncoprotein190.35977.658RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
36 ERCC8oncoprotein160.8585.453WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
DUF4859 (PF16151, IPR032339): Domain of unknown function (DUF4859)
37 ETS1oncoprotein50.7001.667Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
38 ETS2suppressor60.6004.567Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
39 ETV1oncoprotein50.4005.117Ets (PF00178, IPR000418, SM00413): Ets-domain
ETS_PEA3_N (PF04621, IPR006715): PEA3 subfamily ETS-domain transcription factor N terminal domain
40 ETV4oncoprotein21.0000Ets (PF00178, IPR000418, SM00413): Ets-domain
ETS_PEA3_N (PF04621, IPR006715): PEA3 subfamily ETS-domain transcription factor N terminal domain
41 ETV5oncoprotein40.5001.467Ets (PF00178, IPR000418, SM00413): Ets-domain
ETS_PEA3_N (PF04621, IPR006715): PEA3 subfamily ETS-domain transcription factor N terminal domain
42 FOSoncoprotein110.28924.165bZIP_1 (PF00170, IPR004827): bZIP transcription factor
43 FOSL2oncoprotein70.3817.567bZIP_1 (PF00170, IPR004827): bZIP transcription factor
44 FOXO1suppressor40.6670.286K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2
FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
45 HSPA2interactor31.0000HSP70 (PF00012, IPR013126): Hsp70 protein
46 HSPA6interactor60.73319.513HSP70 (PF00012, IPR013126): Hsp70 protein
47 HSPA8oncoprotein160.50872.927HSP70 (PF00012, IPR013126): Hsp70 protein
48 JUNoncoprotein130.31833.418bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
49 JUNBoncoprotein30.6670.286bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
50 JUNDoncoprotein70.5714.519bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
51 KLHL42interactor61.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
Kelch_6 (PF13964): Kelch motif
52 LRR1interactor130.9101.325LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
53 MDM2oncoprotein190.37363.263Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
54 MDM4oncoprotein100.5839.746zf-FLZ (PF04570, IPR007650): zinc-finger of the FCS-type, C2-C2
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
55 MVPoncoprotein50.5006.667Vault (PF01505, IPR002499): Major Vault Protein repeat
DUF2543 (PF10820, IPR020251): Protein of unknown function (DUF2543)
MVP_shoulder (PF11978, IPR021870): Shoulder domain
56 OTUB1interactor60.267113.246Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
57 PARP4interactor21.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
VIT (PF08487, IPR013694, SM00609): Vault protein inter-alpha-trypsin domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
58 PTPN1suppressor21.0000Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
59 PTPN11suppressor31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
60 RB1CC1suppressor21.0000Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
DHC (PF09626, IPR018588): Dihaem cytochrome c
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
ATG11 (PF10377, IPR019460): Autophagy-related protein 11
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Jag_N (PF14804, IPR032782): Jag N-terminus
NPBW (PF15180, IPR013297): Neuropeptides B and W
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
61 RBX1oncoprotein270.54556.792zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
62 RCHY1suppressor80.7142.521C1_2 (PF03107, IPR004146): C1 domain
zf-CHY (PF05495, IPR008913): CHY zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zinc_ribbon_6 (PF14599): Zinc-ribbon
63 REG1Ainteractor100Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
64 SFNsuppressor70.6672.04414-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
65 SIPA1oncoprotein100IncA (PF04156, IPR007285): IncA protein
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Rap_GAP (PF02145, IPR000331): Rap/ran-GAP
66 SKP1oncoprotein130.7316.679Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
67 STK40interactor100.26729.619Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
68 TCEB2interactor91.0000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
69 TCP1interactor120.8941.640Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
70 TP53suppressor390.199657.305DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
71 TRIB1interactor50.6002.286Pkinase (PF00069, IPR000719): Protein kinase domain
72 TRIB2interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
73 TRIB3interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
74 UBE2D1interactor120.41845.624UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
75 UBE2D2oncoprotein110.46732.785UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
76 WDR5interactor70.8570.515WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
77 YWHABinteractor70.5245.84314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
78 YWHAZprotein found in more fusions130.43922.95314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
79 ZNF397interactor21.0000SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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