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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)90
The number (and %) of the onco-proteins32 (35.56 %)
The number (and %) of the tumor suppressors15 (16.67 %)
Total number of binary PPIs (saturation %)589 (14.71 %)
The number (and %) of affected PPIs91 (15.45 %)
The number of possible different fusions21
PPI diameter4
PPI radius2
The average degree of PPI12.378
Assortativity coefficient-0.2157
The network average Clustering coefficient0.559
The number (and %) of a zero Clustering coefficients10 (11.11 %)
The number (and %) of a zero Betweenness Centrality18 (20.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: NUCKS1,RFWD2 All fusions
Proteins found in more fusions RBMX (see 3 fusions); PTPN11 (see 1 fusions); MME (see 1 fusions); ORC2 (see 2 fusions); CUL4A (see 4 fusions); FOXO1 (see 3 fusions); SFN (see 1 fusions); DCAF1 (see 1 fusions); HUWE1 (see 4 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); MDM4 (see 2 fusions); MVP (see 2 fusions); UBE2D2 (see 1 fusions); EWSR1 (see 1 fusions); YWHAZ (see 5 fusions); FOS (see 4 fusions); COPS5 (see 1 fusions); DDB1 (see 4 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 NUCKS1parental protein150.048809.072FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
2 RFWD2parental protein760.1503368.451Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
IncA (PF04156, IPR007285): IncA protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
WD40_like (PF17005, IPR031544): WD40-like domain
3 AK5interactor100ADK (PF00406, IPR000850): Adenylate kinase
Dpy-30 (PF05186, IPR007858): Dpy-30 motif
Zeta_toxin (PF06414, IPR010488): Zeta toxin
AAA_18 (PF13238): AAA domain
4 ATF6interactor31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DUF2749 (PF10907, IPR024475): Protein of unknown function (DUF2749)
5 BTBD2interactor90.8890.552BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PHR (PF08005, IPR012983): PHR domain
6 CCT2interactor140.8027.184Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
7 CCT3interactor120.9242.574Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
8 CCT4interactor140.8027.184Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
9 CCT5interactor130.8335.364Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
10 CCT6Ainteractor120.9242.574Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
11 CCT7interactor120.9242.574Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
12 CCT8interactor140.8027.184Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
13 CDKN1Bsuppressor140.52721.726CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH
14 COPS2suppressor230.628248.134YozE_SAM_like (PF06855, IPR023089): YozE SAM-like fold
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2087 (PF09860, IPR018656): Uncharacterized protein conserved in bacteria (DUF2087)
PCI (PF01399, IPR000717, SM00088): PCI domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
15 COPS3interactor260.63738.864RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
PCI (PF01399, IPR000717, SM00088): PCI domain
16 COPS4interactor270.59855.303DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
PCI (PF01399, IPR000717, SM00088): PCI domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
17 COPS5protein found in more fusions430.362415.578JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
18 COPS6interactor320.488160.740DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
19 COPS7Ainteractor220.76611.782PCI (PF01399, IPR000717, SM00088): PCI domain
20 COPS7Binteractor220.67159.901PCI (PF01399, IPR000717, SM00088): PCI domain
21 COPS8interactor200.8425.429CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
22 CRTC2oncoprotein30.6670.567TORC_N (PF12884, IPR024783): Transducer of regulated CREB activity, N terminus
TORC_M (PF12885, IPR024784): Transducer of regulated CREB activity middle domain
TORC_C (PF12886, IPR024785): Transducer of regulated CREB activity, C terminus
23 CUL1suppressor290.415134.070Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
24 CUL2suppressor200.58441.440Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
25 CUL3protein found in more fusions410.317479.921Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
26 CUL4Aprotein found in more fusions290.56965.513Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
27 CUL4Boncoprotein270.57564.828Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
28 DCAF1protein found in more fusions170.8007.719DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
LisH (PF08513, IPR013720, SM00667): LisH
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
29 DCAF11interactor111.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
30 DDA1interactor190.77811.556DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
31 DDB1protein found in more fusions260.62746.901CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
32 DDB2suppressor240.56152.060WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
33 DET1interactor120.37929.766Det1 (PF09737, IPR019138): De-etiolated protein 1 Det1
34 DMC1interactor200Rad51 (PF08423, IPR013632): Rad51
HHH_5 (PF14520): Helix-hairpin-helix domain
35 ELAVL1oncoprotein210.332322.846RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
36 ERCC8oncoprotein160.8583.563WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
DUF4859 (PF16151, IPR032339): Domain of unknown function (DUF4859)
37 ETS1oncoprotein50.7001.161Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
38 ETS2suppressor70.52411.815Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
39 ETV1oncoprotein50.4003.240Ets (PF00178, IPR000418, SM00413): Ets-domain
ETS_PEA3_N (PF04621, IPR006715): PEA3 subfamily ETS-domain transcription factor N terminal domain
40 ETV4oncoprotein21.0000Ets (PF00178, IPR000418, SM00413): Ets-domain
ETS_PEA3_N (PF04621, IPR006715): PEA3 subfamily ETS-domain transcription factor N terminal domain
41 ETV5oncoprotein40.5003.689Ets (PF00178, IPR000418, SM00413): Ets-domain
ETS_PEA3_N (PF04621, IPR006715): PEA3 subfamily ETS-domain transcription factor N terminal domain
42 EWSR1oncoprotein200.386297.922RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
43 FOSoncoprotein110.28922.988bZIP_1 (PF00170, IPR004827): bZIP transcription factor
44 FOSL2oncoprotein70.3817.767bZIP_1 (PF00170, IPR004827): bZIP transcription factor
45 FOXO1suppressor40.6670.286K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2
FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
46 GLP1Rinteractor1007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
47 HEXIM1oncoprotein40.16722.464APG6 (PF04111, IPR007243): Autophagy protein Apg6
DivIC (PF04977, IPR007060): Septum formation initiator
Shugoshin_N (PF07558, IPR011516): Shugoshin N-terminal coiled-coil region
HEXIM (PF15313, IPR024872): Hexamethylene bis-acetamide-inducible protein
48 HMGB3interactor21.0000HMG_box_2 (PF09011, IPR009071): HMG-box domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
49 HSPA2interactor40.6672.286HSP70 (PF00012, IPR013126): Hsp70 protein
50 HSPA6interactor50.9000.105HSP70 (PF00012, IPR013126): Hsp70 protein
51 HSPA8oncoprotein160.492152.931HSP70 (PF00012, IPR013126): Hsp70 protein
52 HUWE1oncoprotein200.345219.245BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
53 ILF3oncoprotein80.32153.701dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
54 JUNoncoprotein140.29577.043bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
55 JUNBoncoprotein30.6670.286bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
56 JUNDoncoprotein70.5719.471bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
57 KLHL42interactor61.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
Kelch_6 (PF13964): Kelch motif
58 LRR1interactor130.9101.868LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
59 MDM2oncoprotein210.316134.197Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
60 MDM4oncoprotein100.5838.224zf-FLZ (PF04570, IPR007650): zinc-finger of the FCS-type, C2-C2
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
61 MMEsuppressor3010.770Peptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
62 MVPoncoprotein50.5004.551Vault (PF01505, IPR002499): Major Vault Protein repeat
DUF2543 (PF10820, IPR020251): Protein of unknown function (DUF2543)
MVP_shoulder (PF11978, IPR021870): Shoulder domain
63 ORC2protein found in more fusions200ORC2 (PF04084, IPR007220): Origin recognition complex subunit 2
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
64 PARP4interactor21.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
VIT (PF08487, IPR013694, SM00609): Vault protein inter-alpha-trypsin domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
65 PHAXinteractor40.6673.025RNA_GG_bind (PF10258, IPR019385): PHAX RNA-binding domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
66 PRCPinteractor100Peptidase_S28 (PF05577, IPR008758): Serine carboxypeptidase S28
67 PTPN1suppressor30.3338.337Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
68 PTPN11suppressor31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
69 RB1CC1suppressor40.33330.783Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
DHC (PF09626, IPR018588): Dihaem cytochrome c
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
ATG11 (PF10377, IPR019460): Autophagy-related protein 11
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Jag_N (PF14804, IPR032782): Jag N-terminus
NPBW (PF15180, IPR013297): Neuropeptides B and W
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
70 RBM42interactor204.109RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
71 RBMXsuppressor4010.033RBM1CTR (PF08081, IPR012604): RBM1CTR (NUC064) family
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
72 RBX1oncoprotein270.54556.316zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
73 RCHY1suppressor80.7141.970C1_2 (PF03107, IPR004146): C1 domain
zf-CHY (PF05495, IPR008913): CHY zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zinc_ribbon_6 (PF14599): Zinc-ribbon
74 REG1Ainteractor100Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
75 SFNsuppressor70.6671.86314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
76 SIPA1oncoprotein100IncA (PF04156, IPR007285): IncA protein
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Rap_GAP (PF02145, IPR000331): Rap/ran-GAP
77 SKP1oncoprotein130.7315.955Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
78 STK40interactor100.26730.065Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
79 TCEB2interactor91.0000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
80 TCP1interactor130.8724.706Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
81 TP53suppressor400.215542.104DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
82 TRIB1interactor50.6006.730Pkinase (PF00069, IPR000719): Protein kinase domain
83 TRIB2interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
84 TRIB3interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
85 UBE2D1interactor120.43626.509UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
86 UBE2D2oncoprotein110.48915.530UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
87 WDR5interactor70.8570.294WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
88 YWHABinteractor70.5249.66914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
89 YWHAZprotein found in more fusions150.40753.06914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
90 ZNF397interactor21.0000SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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