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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CDH23, CLUHP3 (from a repository: Sat Jul 20 14:30:40 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)6
The number (and %) of the onco-proteins2 (33.33 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)8 (53.33 %)
The number (and %) of affected PPIs4 (50.00 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI1.333
Assortativity coefficient0
The network average Clustering coefficient0.000
The number (and %) of a zero Clustering coefficients6 (100.00 %)
The number (and %) of a zero Betweenness Centrality5 (83.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CLUHP3,CDH23 All fusions
Proteins found in more fusions LYN (see 2 fusions); USH1C (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CLUHP3interactor000NA
2 CDH23parental protein4012.000Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
DUF3364 (PF11844, IPR024564): Domain of unknown function (DUF3364)
Cadherin_3 (PF16184): Cadherin-like
3 CLK1interactor200PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
Pkinase (PF00069, IPR000719): Protein kinase domain
4 LYNoncoprotein200Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
5 PPME1interactor200Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
6 USH1Cprotein found in more fusions200CemA (PF03040, IPR004282): CemA family
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
Saw1 (PF11561, IPR021624): Single strand annealing-weakened 1
DUF3393 (PF11873, IPR024570): Domain of unknown function (DUF3393)
DUF3567 (PF12091, IPR021951): Protein of unknown function (DUF3567)
PRIMA1 (PF16101): Proline-rich membrane anchor 1

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