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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PIEZO1, XPNPEP3 (from a repository: Tue Jul 30 01:14:18 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins6 (21.43 %)
The number (and %) of the tumor suppressors4 (14.29 %)
Total number of binary PPIs (saturation %)66 (17.46 %)
The number (and %) of affected PPIs27 (40.91 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI3.857
Assortativity coefficient-0.1010
The network average Clustering coefficient0.494
The number (and %) of a zero Clustering coefficients7 (25.00 %)
The number (and %) of a zero Betweenness Centrality14 (50.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PIEZO1,XPNPEP3 All fusions
Proteins found in more fusions SORD (see 1 fusions); UBR5 (see 4 fusions); CUL3 (see 1 fusions); VIM (see 1 fusions); XPNPEP3/IDE (see 1 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PIEZO1parental protein80.143200.833CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD)
DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
Piezo_RRas_bdg (PF12166, IPR027272): Piezo non-specific cation channel, R-Ras-binding domain
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
PIEZO (PF15917, IPR031805): Piezo
2 XPNPEP3parental protein190.144339.133AMP_N (PF05195, IPR007865, SM01011): Aminopeptidase P, N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
3 BAG3oncoprotein40.33388.067BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
4 C1QBPinteractor90.306234.600MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
5 C2orf47interactor41.0000Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
6 CFTRsuppressor200ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
7 CHCHD2interactor90.46424.567CHCH (PF06747, IPR010625): CHCH domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
8 CUL3protein found in more fusions70.40019.400Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
9 DSTNinteractor100Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
10 DYRK2interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
11 ECH1interactor31.0000ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
12 GJB2suppressor100Connexin (PF00029, IPR013092, SM00037): Connexin
13 GOLT1Binteractor40.500199.933Got1 (PF04178, IPR007305): Got1/Sft2-like family
14 IDEprotein found in more fusions31.0000Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
15 LACE1interactor50.8335.000AFG1_ATPase (PF03969, IPR005654): AFG1-like ATPase
16 MRPL53interactor100MRP_L53 (PF10780, IPR019716): 39S ribosomal protein L53/MRP-L53
17 MRPL57interactor100MRP-63 (PF14978, IPR016576): Mitochondrial ribosome protein 63
18 NT5DC2interactor21.00005_nucleotid (PF05761, IPR008380): 5' nucleotidase family
19 OBSL1interactor31.0000BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
20 PAK5interactor60.7009.567PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
21 POLDIP2interactor40.6671.333DUF525 (PF04379, IPR007474): ApaG domain
YccV-like (PF08755, IPR011722, SM00992): Hemimethylated DNA-binding protein YccV like
22 RAB5Concoprotein40.6674.833Ras (PF00071, IPR001806, SM00173): Ras family
23 RAB7Asuppressor30.33368.733Ras (PF00071, IPR001806, SM00173): Ras family
24 SORDprotein found in more fusions200ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
25 TSPAN5interactor100Tetraspannin (PF00335, IPR018499): Tetraspanin family
26 UBR5protein found in more fusions50.6678.000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SDA1 (PF05285, IPR007949): SDA1
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
27 VAPAinteractor31.0000DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
28 VIMsuppressor40.6672.000Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region

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