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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins XPNPEP3, UBE2G1 (from a repository: Tue Aug 20 07:01:37 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)41
The number (and %) of the onco-proteins13 (31.71 %)
The number (and %) of the tumor suppressors3 (7.32 %)
Total number of binary PPIs (saturation %)130 (15.85 %)
The number (and %) of affected PPIs41 (31.54 %)
The number of possible different fusions13
PPI diameter5
PPI radius3
The average degree of PPI4.976
Assortativity coefficient-0.2628
The network average Clustering coefficient0.469
The number (and %) of a zero Clustering coefficients7 (17.07 %)
The number (and %) of a zero Betweenness Centrality14 (34.15 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: UBE2G1,XPNPEP3 All fusions
Proteins found in more fusions MARCH6 (see 1 fusions); HUWE1 (see 4 fusions); APP (see 5 fusions); CUL3 (see 1 fusions); XPNPEP3/IDE (see 1 fusions); BAG3 (see 4 fusions); MAP3K1 (see 1 fusions); UBE2G1 (see 1 fusions); PARK2 (see 1 fusions); UBR5 (see 4 fusions); VIM (see 1 fusions); UBA1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 UBE2G1parental protein220.100632.701UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
2 XPNPEP3parental protein190.144327.460AMP_N (PF05195, IPR007865, SM01011): Aminopeptidase P, N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
3 AMFRoncoprotein50.33346.447CUE (PF02845, IPR003892, SM00546): CUE domain
UbiA (PF01040, IPR000537): UbiA prenyltransferase family
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
4 APPprotein found in more fusions130.136272.478APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 BAG3oncoprotein40.3338.122BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
6 C1QBPinteractor100.267104.698MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
7 C2orf47interactor50.50011.703Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
8 CFTRsuppressor3029.212ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
9 CHCHD2interactor90.46417.092CHCH (PF06747, IPR010625): CHCH domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
10 CUL3protein found in more fusions130.212210.297Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
11 CUL9interactor31.0000ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Cullin (PF00888, IPR001373, SM00182): Cullin family
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SDA1 (PF05285, IPR007949): SDA1
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
12 CYP3A4interactor31.0000p450 (PF00067, IPR001128): Cytochrome P450
13 DIO2oncoprotein50.8330.667T4_deiodinase (PF00837, IPR000643): Iodothyronine deiodinase
14 DYRK2interactor30.3338.464Pkinase (PF00069, IPR000719): Protein kinase domain
15 ECH1interactor50.30039.886ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
16 ELAVL1oncoprotein110.244112.353RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
17 FBXL2interactor21.0000Ste50p-SAM (PF09235, IPR015316): Ste50p, sterile alpha motif
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
18 HUWE1oncoprotein70.33377.560BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
19 IDEprotein found in more fusions31.0000Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
20 ITCHinteractor50.6678.178C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
21 LACE1interactor50.8330.500AFG1_ATPase (PF03969, IPR005654): AFG1-like ATPase
22 MAP3K1oncoprotein31.0000zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
23 MARCH6protein found in more fusions41.0000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
GWT1 (PF06423, IPR009447): GWT1
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Wzy_C (PF04932, IPR007016): O-Antigen ligase
RINGv (PF12906, IPR011016, SM00744): RING-variant domain
DUF4064 (PF13273, IPR025273): Protein of unknown function (DUF4064)
24 MRPL53interactor204.171MRP_L53 (PF10780, IPR019716): 39S ribosomal protein L53/MRP-L53
25 MRPL57interactor100MRP-63 (PF14978, IPR016576): Mitochondrial ribosome protein 63
26 NAXEinteractor100YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus
27 NT5DC2interactor21.00005_nucleotid (PF05761, IPR008380): 5' nucleotidase family
28 OBSL1interactor50.16730.876BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
29 PAK5interactor60.7004.781PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
30 PARK2suppressor70.33360.255IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
31 POLDIP2interactor50.50029.364DUF525 (PF04379, IPR007474): ApaG domain
YccV-like (PF08755, IPR011722, SM00992): Hemimethylated DNA-binding protein YccV like
32 RBCK1interactor50.66713.595GAGA (PF09237, IPR015318): GAGA factor
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
33 RBX1oncoprotein70.46747.927zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
34 RC3H1interactor100PaaA_PaaC (PF05138, IPR007814): Phenylacetic acid catabolic protein
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
35 RDH5interactor21.0000adh_short (PF00106, IPR002198): short chain dehydrogenase
36 UBA1protein found in more fusions80.28667.001ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
37 UBR5protein found in more fusions50.6673.286CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SDA1 (PF05285, IPR007949): SDA1
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
38 UNKinteractor31.0000MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
39 USP8interactor200DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
SET (PF00856, IPR001214, SM00317): SET domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
40 VIMsuppressor60.40018.927Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
41 WWP2interactor200WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)

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