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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)108
The number (and %) of the onco-proteins31 (28.70 %)
The number (and %) of the tumor suppressors9 (8.33 %)
Total number of binary PPIs (saturation %)889 (15.39 %)
The number (and %) of affected PPIs107 (12.04 %)
The number of possible different fusions28
PPI diameter5
PPI radius3
The average degree of PPI15.574
Assortativity coefficient-0.0796
The network average Clustering coefficient0.521
The number (and %) of a zero Clustering coefficients8 (7.41 %)
The number (and %) of a zero Betweenness Centrality14 (12.96 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: AMBRA1,XPNPEP3 All fusions
Proteins found in more fusions TRAF6 (see 1 fusions); CUL4A (see 4 fusions); HSP90AA1 (see 6 fusions); HSP90AA1/PSMA3 (see 1 fusions); GABARAP (see 2 fusions); BECN1 (see 1 fusions); CUL7 (see 2 fusions); ACTN1 (see 3 fusions); CUL3 (see 1 fusions); PSMB3 (see 1 fusions); PARK2 (see 1 fusions); MYC (see 2 fusions); BAG2 (see 1 fusions); HSP90AA1/PSMB5 (see 1 fusions); XPNPEP3/IDE (see 1 fusions); BAG3 (see 4 fusions); ULK1 (see 2 fusions); UBR5 (see 4 fusions); PSMA7 (see 5 fusions); COPS5 (see 1 fusions); UBC (see 7 fusions); MTOR (see 1 fusions); DDB1 (see 4 fusions); RPTOR (see 3 fusions); PSMC5 (see 2 fusions); VIM (see 1 fusions); HSPA8/HSPD1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AMBRA1parental protein880.1534374.460Acyl_CoA_thio (PF02551, IPR025652): Acyl-CoA thioesterase
eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Spt20 (PF12090, IPR021950): Spt20 family
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
2 XPNPEP3parental protein190.144705.909AMP_N (PF05195, IPR007865, SM01011): Aminopeptidase P, N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
3 ACTN1protein found in more fusions80.3819.525CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
4 ASB8interactor30.6670.725Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
5 ATG13oncoprotein40.6672.669ATG13 (PF10033, IPR018731): Autophagy-related protein 13
6 ATG3interactor70.28617.276Autophagy_C (PF10381, IPR019461): Autophagocytosis associated protein C-terminal
Autophagy_N (PF03986, IPR007134): Autophagocytosis associated protein (Atg3), N-terminal domain
Autophagy_act_C (PF03987, IPR007135): Autophagocytosis associated protein, active-site domain
7 ATG4Binteractor60.5339.100Peptidase_C54 (PF03416, IPR005078): Peptidase family C54
8 BAG2protein found in more fusions160.52426.059IncA (PF04156, IPR007285): IncA protein
Mnd1 (PF03962, IPR005647): Mnd1 family
ParD_antitoxin (PF03693, IPR022789): Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH
9 BAG3oncoprotein310.306366.667BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
10 BAG5interactor50.4003.379BAG (PF02179, IPR003103, SM00264): BAG domain
PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
RRF (PF01765, IPR023584): Ribosome recycling factor
11 BCL2oncoprotein90.50011.910Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
12 BECN1suppressor150.30862.999APG6 (PF04111, IPR007243): Autophagy protein Apg6
Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain
BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
13 C1QBPinteractor200.274621.087MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
14 C2orf47interactor41.0000Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
15 CAMKMTinteractor80.5006.908Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
16 CCT2interactor180.54228.529Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
17 CCT3interactor190.50340.456Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
18 CCT4interactor140.63713.363Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
19 CCT8interactor160.53328.956Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
20 CFTRsuppressor170.25896.996ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
21 CHCHD2interactor90.46424.615CHCH (PF06747, IPR010625): CHCH domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
22 CISHinteractor30.6670.836SH2 (PF00017, IPR000980, SM00252): SH2 domain
ER-remodelling (PF14755, IPR032786): Intracellular membrane remodeller
SOCS_box (PF07525, IPR001496): SOCS box
23 COPS5protein found in more fusions230.381106.112JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
24 COPS8interactor100.7509.474CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
25 CUL3protein found in more fusions420.161964.354Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
26 CUL4Aprotein found in more fusions200.46275.472Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
27 CUL4Boncoprotein170.49357.730Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
28 CUL7protein found in more fusions210.33291.193ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
29 DDA1interactor61.0000DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
30 DDB1protein found in more fusions200.322135.389CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
31 DNAJB1suppressor100.7118.915DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
32 DYNC1I1interactor50.5007.977CDC45 (PF02724, IPR003874): CDC45-like protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Dynein_IC2 (PF11540, IPR025956): Cytoplasmic dynein 1 intermediate chain 2
AviRa (PF11599, IPR024268): RRNA methyltransferase AviRa
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
33 DYNLL1interactor60.6003.088Dynein_light (PF01221, IPR001372): Dynein light chain type 1
34 DYRK2interactor60.33319.767Pkinase (PF00069, IPR000719): Protein kinase domain
35 ECH1interactor31.0000ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
36 F12interactor31.0000EGF (PF00008, IPR000742, SM00181): EGF-like domain
fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
Kringle (PF00051, IPR000001): Kringle domain
Trypsin (PF00089, IPR001254, SM00020): Trypsin
37 FBXW11interactor120.23634.800WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
38 GABARAPsuppressor80.42925.088Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
39 GPS1interactor80.7863.558RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7
PCI (PF01399, IPR000717, SM00088): PCI domain
40 HPS1interactor21.0000Mon1 (PF03164, IPR004353): Trafficking protein Mon1
DUF4719 (PF15843, IPR031696): Domain of unknown function (DUF4719)
41 HSP90AA1oncoprotein330.234323.107HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
42 HSPA5oncoprotein240.41599.279HSP70 (PF00012, IPR013126): Hsp70 protein
43 HSPA8oncoprotein260.391176.940HSP70 (PF00012, IPR013126): Hsp70 protein
44 HSPD1suppressor160.51734.741Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
45 IDEprotein found in more fusions50.30044.548Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
46 IRGMinteractor41.0000IIGP (PF05049, IPR007743): Interferon-inducible GTPase (IIGP)
47 LACE1interactor50.8339.782AFG1_ATPase (PF03969, IPR005654): AFG1-like ATPase
48 LRRC29interactor100Glyco_tran_WecB (PF03808, IPR004629): Glycosyl transferase WecB/TagA/CpsF family
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
Ste50p-SAM (PF09235, IPR015316): Ste50p, sterile alpha motif
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
49 LRRC42interactor30.3332.464LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
50 MAP1Binteractor60.3338.976DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
MAP1B_neuraxin (PF00414, IPR000102): Neuraxin and MAP1B repeat
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
Striatin (PF08232, IPR013258): Striatin family
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
51 MRPL53interactor309.384MRP_L53 (PF10780, IPR019716): 39S ribosomal protein L53/MRP-L53
52 MRPL57interactor100MRP-63 (PF14978, IPR016576): Mitochondrial ribosome protein 63
53 MTORoncoprotein70.7332.286DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
TPR_19 (PF14559): Tetratricopeptide repeat
54 MYConcoprotein320.374293.019HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
55 NESinteractor60.06743.645Anthrax-tox_M (PF09156, IPR015239): Anthrax toxin lethal factor, middle domain
Filament (PF00038, IPR001664): Intermediate filament protein
HSCB_C (PF07743, IPR009073): HSCB C-terminal oligomerisation domain
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Prominin (PF05478, IPR008795): Prominin
56 NT5DC2interactor21.00005_nucleotid (PF05761, IPR008380): 5' nucleotidase family
57 OBSL1interactor170.250114.522BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
58 PAK5interactor60.7002.224PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
59 PARK2suppressor450.392419.382IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
60 PIK3C3interactor60.7332.109PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
61 POLDIP2interactor50.50029.808DUF525 (PF04379, IPR007474): ApaG domain
YccV-like (PF08755, IPR011722, SM00992): Hemimethylated DNA-binding protein YccV like
62 PPP2CAsuppressor130.43625.083Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
63 PPP2R1Aoncoprotein140.385118.105TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
64 PRAMEF5interactor100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_2 (PF07723, IPR013101): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
65 PSMA1interactor320.645106.876Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
66 PSMA2interactor310.74537.437Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
67 PSMA3protein found in more fusions380.569103.303Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
68 PSMA4interactor240.9711.739Proteasome (PF00227, IPR001353): Proteasome subunit
U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
69 PSMA5oncoprotein290.79128.690Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
70 PSMA6interactor310.68061.386Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
71 PSMA7protein found in more fusions290.82027.470Proteasome (PF00227, IPR001353): Proteasome subunit
Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
72 PSMB2interactor250.9179.760Proteasome (PF00227, IPR001353): Proteasome subunit
73 PSMB3protein found in more fusions270.87716.991Proteasome (PF00227, IPR001353): Proteasome subunit
74 PSMB5protein found in more fusions290.78330.615Proteasome (PF00227, IPR001353): Proteasome subunit
75 PSMC1interactor280.82824.045AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815)
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
76 PSMC2interactor360.625102.015AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
77 PSMC3interactor310.75933.199AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
78 PSMC4interactor310.69068.635AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
NTPase_1 (PF03266, IPR004948): NTPase
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
AAA_16 (PF13191): AAA ATPase domain
79 PSMC5protein found in more fusions320.72949.220AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
80 PSMC6interactor310.72643.907AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
81 PSMD10interactor160.8584.931Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
82 PSMD12interactor290.82516.207Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
PCI (PF01399, IPR000717, SM00088): PCI domain
83 PSMD13interactor250.9105.129Mitovir_RNA_pol (PF05919, IPR008686): Mitovirus RNA-dependent RNA polymerase
PCI (PF01399, IPR000717, SM00088): PCI domain
84 PSMD2oncoprotein310.68473.637PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
85 PSMD3interactor290.76135.649Rpn3_C (PF08375, IPR013586): Proteasome regulatory subunit C-terminal
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PCI (PF01399, IPR000717, SM00088): PCI domain
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
TSKS (PF15358, IPR028214): Testis-specific serine kinase substrate
86 PSMD6interactor250.9007.400RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7
PCI (PF01399, IPR000717, SM00088): PCI domain
87 PSMD8interactor260.9175.875CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
88 RFPL4Binteractor100SPRY (PF00622, IPR003877, SM00449): SPRY domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
89 RNF2interactor140.41052.271zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
90 RPTORprotein found in more fusions100.47217.217HEAT (PF02985, IPR000357): HEAT repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
HEAT_2 (PF13646): HEAT repeats
Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain
91 STIP1interactor100.5785.986TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
Wtap (PF17098, IPR029732): WTAP/Mum2p family
92 STUB1suppressor190.46447.490U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
93 SUGT1interactor80.46410.195CheC (PF04509, IPR007597): CheC-like family
CS (PF04969, IPR007052): CS domain
SGS (PF05002, IPR007699): SGS domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
94 TBC1D22Ainteractor100RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
95 TCEB2interactor60.26725.158ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
96 TRAF6protein found in more fusions170.44239.913SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
97 TRIM10interactor50.5001.056IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
SPRY (PF00622, IPR003877, SM00449): SPRY domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
98 TUBA1Aoncoprotein120.42431.522Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
99 TUBB3interactor70.38117.124Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
100 UBCprotein found in more fusions490.309683.084ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
101 UBE2D3interactor120.34545.634UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
102 UBL4Ainteractor90.55659.889ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
103 UBR5protein found in more fusions110.28970.985CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SDA1 (PF05285, IPR007949): SDA1
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
104 ULK1protein found in more fusions100.41717.882Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
105 USP50interactor41.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
106 VIMsuppressor140.30881.024Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
107 VPS50interactor100Vps54_N (PF10475, IPR019515): Vacuolar-sorting protein 54, of GARP complex
DUF2451 (PF10474, IPR019514): Protein of unknown function C-terminus (DUF2451)
108 WDR1interactor302.708eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain

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