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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SNX24, XPNPEP3 (from a repository: Thu Aug 8 23:15:41 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)32
The number (and %) of the onco-proteins8 (25.00 %)
The number (and %) of the tumor suppressors3 (9.38 %)
Total number of binary PPIs (saturation %)83 (16.73 %)
The number (and %) of affected PPIs31 (37.35 %)
The number of possible different fusions8
PPI diameter5
PPI radius3
The average degree of PPI4.312
Assortativity coefficient-0.1996
The network average Clustering coefficient0.516
The number (and %) of a zero Clustering coefficients7 (21.88 %)
The number (and %) of a zero Betweenness Centrality15 (46.88 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: XPNPEP3,SNX24 All fusions
Proteins found in more fusions UGP2 (see 1 fusions); YWHAZ (see 5 fusions); UBR5 (see 4 fusions); CUL3 (see 1 fusions); VIM (see 1 fusions); XPNPEP3/IDE (see 1 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 XPNPEP3parental protein190.144391.050AMP_N (PF05195, IPR007865, SM01011): Aminopeptidase P, N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
2 SNX24parental protein120.106334.952PX (PF00787, IPR001683, SM00312): PX domain
3 BAG3oncoprotein40.66713.968BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
4 C1QBPinteractor80.39351.031MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
5 C1orf111interactor21.0000zf-C2H2_4 (PF13894): C2H2-type zinc finger
6 C2orf47interactor41.0000Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
7 CFTRsuppressor3028.197ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
8 CHCHD2interactor90.46412.500CHCH (PF06747, IPR010625): CHCH domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
9 CSNK1A1suppressor40.66711.615Pkinase (PF00069, IPR000719): Protein kinase domain
10 CSNK1Einteractor41.0000APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
11 CUL3protein found in more fusions90.250112.318Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
12 DYRK2interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
13 ECH1interactor31.0000ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
14 FLNCinteractor3060.689CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
15 IDEprotein found in more fusions31.0000Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
16 ITFG2interactor21.0000BBS2_Mid (PF14783, IPR029429): Ciliary BBSome complex subunit 2, middle region
Itfg2 (PF15907, IPR031793): Integrin-alpha FG-GAP repeat-containing protein 2
17 KPTNinteractor21.0000AcetylCoA_hyd_C (PF13336, IPR026888): Acetyl-CoA hydrolase/transferase C-terminal domain
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
BBS2_Mid (PF14783, IPR029429): Ciliary BBSome complex subunit 2, middle region
18 LACE1interactor50.8330.667AFG1_ATPase (PF03969, IPR005654): AFG1-like ATPase
19 MRPL53interactor100MRP_L53 (PF10780, IPR019716): 39S ribosomal protein L53/MRP-L53
20 MRPL57interactor100MRP-63 (PF14978, IPR016576): Mitochondrial ribosome protein 63
21 NT5DC2interactor21.00005_nucleotid (PF05761, IPR008380): 5' nucleotidase family
22 OBSL1interactor60.20094.126BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
23 PAK5interactor60.7001.833PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
24 POLDIP2interactor40.6675.705DUF525 (PF04379, IPR007474): ApaG domain
YccV-like (PF08755, IPR011722, SM00992): Hemimethylated DNA-binding protein YccV like
25 RAP1GDS1oncoprotein100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
WAPL (PF07814, IPR022771): Wings apart-like protein regulation of heterochromatin
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
HEAT_2 (PF13646): HEAT repeats
Nitr_red_bet_C (PF14711, IPR029263): Respiratory nitrate reductase beta C-terminal
SIL1 (PF16782, IPR031884): Nucleotide exchange factor SIL1
26 SEPT2oncoprotein21.0000FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
Septin (PF00735, IPR000038): Septin
27 TSSK1Binteractor100Pkinase (PF00069, IPR000719): Protein kinase domain
28 UBR5protein found in more fusions60.40072.665CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SDA1 (PF05285, IPR007949): SDA1
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
29 UGP2protein found in more fusions200UDPGP (PF01704, IPR002618): UTP--glucose-1-phosphate uridylyltransferase
30 VIMsuppressor60.50049.936Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
31 XPO1interactor90.194231.496CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
32 YWHAZprotein found in more fusions70.333113.25314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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