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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SOCS5, PRDM1 (from a repository: Thu Dec 6 17:01:40 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)34
The number (and %) of the onco-proteins14 (41.18 %)
The number (and %) of the tumor suppressors6 (17.65 %)
Total number of binary PPIs (saturation %)101 (18.00 %)
The number (and %) of affected PPIs33 (32.67 %)
The number of possible different fusions12
PPI diameter5
PPI radius3
The average degree of PPI4.824
Assortativity coefficient-0.2076
The network average Clustering coefficient0.507
The number (and %) of a zero Clustering coefficients5 (14.71 %)
The number (and %) of a zero Betweenness Centrality13 (38.24 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PRDM1,SOCS5 All fusions
Proteins found in more fusions PIAS1 (see 2 fusions); KDM1A (see 2 fusions); HSP90AA1 (see 5 fusions); SENP1 (see 1 fusions); PRMT5 (see 2 fusions); TLE2 (see 2 fusions); APP (see 4 fusions); EGFR (see 2 fusions); ATXN1 (see 3 fusions); HDAC1 (see 1 fusions); UBC (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PRDM1parental protein250.101657.847SET (PF00856, IPR001214, SM00317): SET domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
2 SOCS5parental protein80.143140.328SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS (PF12610, IPR001496, SM00253): Suppressor of cytokine signalling
SOCS_box (PF07525, IPR001496): SOCS box
3 ALKoncoprotein3016.160MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Gly_rich (PF12810): Glycine rich protein
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
4 APPprotein found in more fusions90.28670.548APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ATXN1protein found in more fusions40.6671.000AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
6 CASP3interactor50.33325.085Peptidase_C14 (PF00656, IPR011600): Caspase domain
7 DCUN1D1interactor50.40022.682Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
8 EGFRoncoprotein70.46724.710Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
9 EHMT2interactor60.5005.000CDC45 (PF02724, IPR003874): CDC45-like protein
Pre-SET (PF05033, IPR007728): Pre-SET motif
Ribosomal_L32p (PF01783, IPR002677): Ribosomal L32p protein family
SET (PF00856, IPR001214, SM00317): SET domain
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus
10 ELAVL1oncoprotein50.50024.279RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
11 GTF2Iinteractor41.0000GTF2I (PF02946, IPR004212): GTF2I-like repeat
12 HDAC1suppressor90.42928.621FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
13 HDAC2suppressor90.46419.732Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
14 HIST1H1Ainteractor21.0000Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
15 HIST2H3Ainteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
16 HSP90AA1oncoprotein110.289104.087HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
17 HSPA5oncoprotein70.46745.121HSP70 (PF00012, IPR013126): Hsp70 protein
18 HSPA9oncoprotein60.46740.251HSP70 (PF00012, IPR013126): Hsp70 protein
19 HSPD1suppressor80.21498.502Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
20 IKZF3suppressor40.33320.501C1_2 (PF03107, IPR004146): C1 domain
Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2H2_7 (PF15269): Zinc-finger
21 IL4Roncoprotein100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
IL4Ra_N (PF09238, IPR015319): Interleukin-4 receptor alpha chain, N-terminal
22 IRF1suppressor31.0000IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
23 IRF2interactor40.66711.511IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
24 KDM1Aprotein found in more fusions51.0000Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
25 MS4A1interactor100CD20 (PF04103, IPR007237): CD20-like family
CM2 (PF03021, IPR004267): Influenza C virus M2 protein
26 PIAS1suppressor31.0000Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
27 PRMT5protein found in more fusions31.0000PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
28 PRMT7interactor100Cons_hypoth95 (PF03602, IPR004398): Conserved hypothetical protein 95
PrmA (PF06325, IPR010456): Ribosomal protein L11 methyltransferase (PrmA)
29 SENP1protein found in more fusions60.50021.315Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
30 TLE1interactor40.6671.000TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
31 TLE2protein found in more fusions31.0000TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain
32 TMBIM1interactor100Bax1-I (PF01027, IPR006214): Inhibitor of apoptosis-promoting Bax1
33 UBCprotein found in more fusions70.33337.722ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
34 ZBTB32interactor21.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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