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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)119
The number (and %) of the onco-proteins26 (21.85 %)
The number (and %) of the tumor suppressors9 (7.56 %)
Total number of binary PPIs (saturation %)628 (8.94 %)
The number (and %) of affected PPIs118 (18.79 %)
The number of possible different fusions16
PPI diameter5
PPI radius3
The average degree of PPI10.000
Assortativity coefficient-0.1843
The network average Clustering coefficient0.432
The number (and %) of a zero Clustering coefficients14 (11.76 %)
The number (and %) of a zero Betweenness Centrality21 (17.65 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SDHA,ESRRG All fusions
Proteins found in more fusions APP (see 4 fusions); CUL4A (see 4 fusions); CRY2 (see 3 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); SQSTM1 (see 5 fusions); NCOA1 (see 2 fusions); SP1 (see 1 fusions); NDUFS3 (see 1 fusions); MDH2 (see 1 fusions); HSPB1 (see 4 fusions); COPS5 (see 1 fusions); OXCT1 (see 1 fusions); UBC (see 4 fusions); PSMC5 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SDHAparental protein900.0976166.376FAD_binding_2 (PF00890, IPR003953): FAD binding domain
Succ_DH_flav_C (PF02910, IPR015939): Fumarate reductase flavoprotein C-term
2 ESRRGparental protein280.0681768.788zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
3 ACAT1interactor160.41045.876Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
4 ACLYinteractor140.39671.798ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain
Citrate_synt (PF00285, IPR002020): Citrate synthase, C-terminal domain
CoA_binding (PF02629, IPR003781, SM00881): CoA binding domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
Citrate_bind (PF16114, IPR032263): ATP citrate lyase citrate-binding
5 APPprotein found in more fusions220.129824.486APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 ARHGEF15interactor100Med14 (PF08638, IPR013947): Mediator complex subunit MED14
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
7 ARRB2interactor90.38937.533Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
8 ATP1B1interactor140.49535.631Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
9 ATP5F1interactor100.57812.056Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
DUF2105 (PF09878, IPR019212): Predicted membrane protein (DUF2105)
10 CAND1interactor230.437102.896Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
11 CEP128interactor50.400154.114DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
12 COPS5protein found in more fusions260.407359.786JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
13 COPS6interactor140.8334.700DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
14 CPNE1interactor40.5001.866C2 (PF00168, IPR000008, SM00239): C2 domain
Copine (PF07002, IPR010734): Copine
15 CPNE3interactor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
Copine (PF07002, IPR010734): Copine
16 CRY1interactor90.39317.442DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
17 CRY2protein found in more fusions120.41825.755DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
18 CSinteractor60.5332.900Citrate_synt (PF00285, IPR002020): Citrate synthase, C-terminal domain
19 CSNK2Binteractor80.286162.201CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
20 CUL1suppressor230.46887.985Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
21 CUL2suppressor160.65016.728Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
22 CUL3protein found in more fusions360.272519.865Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
23 CUL4Aprotein found in more fusions120.9450.493Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
24 CUL5suppressor170.67622.382Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
25 CYB5R3interactor60.66712.200FAD_binding_6 (PF00970, IPR008333): Oxidoreductase FAD-binding domain
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
26 CYC1interactor120.39448.753Cytochrom_C1 (PF02167, IPR002326): Cytochrome C1 family
27 DCUN1D1interactor120.9240.836Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
28 DEUP1suppressor40.33333.327APG6 (PF04111, IPR007243): Autophagy protein Apg6
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
CEP63 (PF17045, IPR031470): Centrosomal protein of 63 kDa
29 DHODHinteractor31.0000DHO_dh (PF01180, IPR012135): Dihydroorotate dehydrogenase
FMN_dh (PF01070, IPR000262): FMN-dependent dehydrogenase
PASTA (PF03793, IPR005543, SM00740): PASTA domain
30 DLDinteractor100.44415.729Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
31 DNAJA3suppressor70.5716.306DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
32 DNMT3Linteractor100CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
33 DUTinteractor50.40077.610dUTPase (PF00692, IPR008180): dUTPase
34 EBPinteractor30.33312.964Phage_holin_3_6 (PF07332, IPR009937): Putative Actinobacterial Holin-X, holin superfamily III
EBP (PF05241, IPR007905): Emopamil binding protein
35 EIF4A1interactor130.39726.340DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
36 ESRRAoncoprotein120.242266.436zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
37 FBXO6interactor140.30859.718FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
38 FN1oncoprotein200.242217.217fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
39 GCN1interactor80.4647.750Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
CLASP_N (PF12348, IPR024395): CLASP N terminal
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
40 GLOD4interactor40.33351.066Glyoxalase (PF00903, IPR004360): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
41 HGSinteractor80.286126.648FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
42 HIGD1Ainteractor100HIG_1_N (PF04588, IPR007667): Hypoxia induced protein conserved region
MitoNEET_N (PF10660, IPR019610): Iron-containing outer mitochondrial membrane protein N-terminus
43 HSPA9oncoprotein270.293409.082HSP70 (PF00012, IPR013126): Hsp70 protein
44 HSPB1oncoprotein170.317112.207HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
45 HSPB2interactor31.0000Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
46 IMPAD1interactor100Inositol_P (PF00459, IPR000760): Inositol monophosphatase family
47 ITGA4interactor150.34133.583FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
48 KIFC3oncoprotein40.6677.330Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
49 LRRC8Ainteractor21.0000LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
Pannexin_like (PF12534, IPR021040): Pannexin-like TM region of LRRC8
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
50 MARC1interactor40.50011.256MOSC (PF03473, IPR005302): MOSC domain
MOSC_N (PF03476, IPR005303): MOSC N-terminal beta barrel domain
51 MDH1interactor60.40038.427Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
52 MDH2protein found in more fusions80.42914.778Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
53 MEOX2interactor30.33334.284Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
54 MRPL1interactor50.60010.635CUB_2 (PF02408, IPR003366): CUB-like domain
Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
55 MRPL58interactor170.279132.421RF-1 (PF00472, IPR000352): RF-1 domain
56 MRPS9interactor50.7001.741Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
57 MTCH1interactor41.0000YdjM (PF04307, IPR007404): LexA-binding, inner membrane-associated putative hydrolase
Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
58 MTERF3interactor40.50010.232mTERF (PF02536, IPR003690, SM00733): mTERF
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
59 NAXEinteractor100YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus
60 NCOA1oncoprotein50.50063.222DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
61 NDUFA2interactor120.45575.913L51_S25_CI-B8 (PF05047, IPR007741, SM00916): Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
62 NDUFS2interactor170.338156.420Complex1_49kDa (PF00346, IPR001135): Respiratory-chain NADH dehydrogenase, 49 Kd subunit
NiFeSe_Hases (PF00374, IPR001501): Nickel-dependent hydrogenase
63 NDUFS3protein found in more fusions270.308246.579Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
64 NDUFS6interactor90.63910.625Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
zf-CHCC (PF10276, IPR019401, SM00400): Zinc-finger domain
65 NDUFS8interactor140.38556.430Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
Fer4_16 (PF13484): 4Fe-4S double cluster binding domain
66 NDUFV1interactor170.42653.469Complex1_51K (PF01512, IPR011538): Respiratory-chain NADH dehydrogenase 51 Kd subunit
NADH_4Fe-4S (PF10589, IPR019575, SM00928): NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
SLBB (PF10531, IPR019554): SLBB domain
67 NDUFV2interactor100.60011.7432Fe-2S_thioredx (PF01257, IPR002023): Thioredoxin-like [2Fe-2S] ferredoxin
68 NEDD8interactor160.59038.929ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
69 NR0B1interactor31.0000zf-C4_ClpX (PF06689, IPR010603, SM00994): ClpX C4-type zinc finger
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
NR_Repeat (PF14046, IPR025900): Nuclear receptor repeat
70 NR0B2suppressor40.33363.960Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
71 NRIP1oncoprotein50.60030.469ALMT (PF11744, IPR020966): Aluminium activated malate transporter
NRIP1_repr_1 (PF15687, IPR031405): Nuclear receptor-interacting protein 1 repression 1
NRIP1_repr_2 (PF15688, IPR031406): Nuclear receptor-interacting protein 1 repression 2
NRIP1_repr_3 (PF15689, IPR031407): Nuclear receptor-interacting protein 1 repression 3
NRIP1_repr_4 (PF15690, IPR031408): Nuclear receptor-interacting protein 1 repression 4
72 NTRK1oncoprotein450.1451240.191I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
73 NUP160interactor40.16759.952Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
74 NXF1interactor280.228640.294NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
75 OTUB1interactor60.6001.938Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
76 OXCT1protein found in more fusions110.42224.670CoA_trans (PF01144, IPR004165, SM00882): Coenzyme A transferase
77 PARK2suppressor200.135571.321IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
78 PDHA1interactor100.48912.147E1_dh (PF00676, IPR001017): Dehydrogenase E1 component
79 PNRC1interactor100PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
80 PNRC2interactor40.33331.459PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
81 PPARGC1Ainteractor40.8330.667Pap_E4 (PF02711, IPR003861): E4 protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RSRP (PF17069): Arginine/Serine-Rich protein 1
82 PPIBinteractor30.6670.530Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
83 PROCRinteractor100MHC_I_3 (PF16497, IPR011161): MHC-I family domain
84 PROX1suppressor30.33341.621GET2 (PF08690, IPR028143): GET complex subunit GET2
NifQ (PF04891, IPR006975): NifQ
HPD (PF05044, IPR023082): Homeo-prospero domain
PP_kinase_N (PF13089, IPR025198): Polyphosphate kinase N-terminal domain
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
85 PSMC5protein found in more fusions140.218277.320AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
86 PSMD1interactor110.47332.378PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
HEAT_2 (PF13646): HEAT repeats
87 RAB14oncoprotein30.33313.974Ras (PF00071, IPR001806, SM00173): Ras family
88 RAVER1interactor21.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
89 RPGRIP1Linteractor31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
C2 (PF00168, IPR000008, SM00239): C2 domain
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FtsL (PF04999, IPR011922): Cell division protein FtsL
T3SS_needle_F (PF09392, IPR021123): Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
C2-C2_1 (PF11618, IPR021656): First C2 domain of RPGR-interacting protein 1
BNIP2 (PF12496, IPR022181): Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4497 (PF14924): Protein of unknown function (DUF4497)
90 SAMM50interactor50.60091.671Bac_surface_Ag (PF01103, IPR000184): Surface antigen
POTRA (PF07244, IPR010827): Surface antigen variable number repeat
91 SDHAF2oncoprotein50.5004.262Sdh5 (PF03937, IPR005631): Flavinator of succinate dehydrogenase
Peroxidase_2 (PF01328, IPR000028): Peroxidase, family 2
Reovirus_cap (PF00979, IPR000153): Reovirus outer capsid protein, Sigma 3
92 SDHBsuppressor250.210184.153Fer2_3 (PF13085, IPR025192): 2Fe-2S iron-sulfur cluster binding domain
Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain
Fer4_17 (PF13534): 4Fe-4S dicluster domain
93 SDHConcoprotein40.5001.186Sdh_cyt (PF01127, IPR000701): Succinate dehydrogenase/Fumarate reductase transmembrane subunit
94 SHTN1interactor3030.924Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
VIT1 (PF01988, IPR008217): VIT family
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
DUF3484 (PF11983, IPR021873): Membrane-attachment and polymerisation-promoting switch
Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
95 SIRT7interactor180.190251.311DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
96 SLC27A2interactor100AMP-binding (PF00501, IPR000873): AMP-binding enzyme
AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
97 SLC2A14interactor100Sugar_tr (PF00083, IPR005828): Sugar (and other) transporter
98 SP1protein found in more fusions60.50034.213zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
99 SQSTM1oncoprotein120.67311.599PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
100 SRA1interactor100SRA1 (PF07304, IPR009917): Steroid receptor RNA activator (SRA1)
101 SRPK1interactor70.47699.269FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
102 SUCLA2interactor60.5337.581ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
nsp7 (PF08716, IPR014828): nsp7 replicase
103 SUCLG1interactor50.6002.467CoA_binding (PF02629, IPR003781, SM00881): CoA binding domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
CoA_binding_2 (PF13380, IPR003781): CoA binding domain
104 SUCLG2interactor60.3339.513ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
105 SUMO1P1interactor200NA
106 SYNE2oncoprotein50.5003.544ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
Fez1 (PF06818): Fez1
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Laminin_II (PF06009, IPR010307): Laminin Domain II
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
SlyX (PF04102, IPR007236): SlyX
Spectrin (PF00435, IPR002017): Spectrin repeat
TMPIT (PF07851, IPR012926): TMPIT-like protein
KASH (PF10541, IPR012315): Nuclear envelope localisation domain
HD_5 (PF13487): HD domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
DUF4363 (PF14276, IPR025373): Domain of unknown function (DUF4363)
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
TRPM_tetra (PF16519, IPR032415): Tetramerisation domain of TRPM
107 TAP1oncoprotein21.0000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
108 TIMM50interactor70.5714.516NIF (PF03031, IPR004274): NLI interacting factor-like phosphatase
109 TLE1interactor3022.822TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
110 TMEM14Binteractor100Tmemb_14 (PF03647, IPR005349): Transmembrane proteins 14C
111 TMEM67interactor30.6676.711Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
Tme5_EGF_like (PF09064, IPR015149): Thrombomodulin like fifth domain, EGF-like
Meckelin (PF09773, IPR019170): Meckelin (Transmembrane protein 67)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
112 TOMM70interactor50.40010.101PBP_GOBP (PF01395, IPR006170, SM00708): PBP/GOBP family
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
NRBF2_MIT (PF17169): MIT domain of nuclear receptor-binding factor 2
113 UBCprotein found in more fusions320.299293.767ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
114 UBXN10interactor30.33312.059UBX (PF00789, IPR001012, SM00166): UBX domain
115 UQCRBinteractor110.58211.508UCR_14kD (PF02271, IPR003197): Ubiquinol-cytochrome C reductase complex 14kD subunit
116 UQCRFS1interactor160.34266.530Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain
Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
117 UQCRQinteractor100.53310.360UcrQ (PF02939, IPR004205): UcrQ family
118 XRCC6oncoprotein160.324149.163Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain
119 ZC3H4interactor30.6672.019API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
Baculo_PP31 (PF05311, IPR007975): Baculovirus 33KDa late protein (PP31)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381)
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
Torus (PF16131, IPR032297): Torus domain

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