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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)262
The number (and %) of the onco-proteins56 (21.37 %)
The number (and %) of the tumor suppressors28 (10.69 %)
Total number of binary PPIs (saturation %)912 (2.67 %)
The number (and %) of affected PPIs264 (28.95 %)
The number of possible different fusions39
PPI diameter4
PPI radius2
The average degree of PPI6.176
Assortativity coefficient-0.2966
The network average Clustering coefficient0.394
The number (and %) of a zero Clustering coefficients69 (26.34 %)
The number (and %) of a zero Betweenness Centrality90 (34.35 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SDCBP,MME All fusions
Proteins found in more fusions PTPRJ (see 2 fusions); TRAF6 (see 1 fusions); MME (see 1 fusions); AES (see 3 fusions); LMNA (see 4 fusions); PUF60 (see 1 fusions); RUVBL1 (see 1 fusions); LYN (see 2 fusions); RP9P (see 1 fusions); EEF1A1 (see 6 fusions); SDCBP/FLAD1 (see 1 fusions); DCTD (see 1 fusions); PTS (see 1 fusions); SLC9A3R1 (see 2 fusions); KCTD9 (see 1 fusions); UTRN (see 4 fusions); IMPDH2 (see 1 fusions); NF2 (see 1 fusions); IKZF1 (see 1 fusions); EWSR1 (see 1 fusions); NT5C2 (see 5 fusions); SSNA1 (see 2 fusions); ULK1 (see 2 fusions); NAGK (see 1 fusions); HSPB1 (see 1 fusions); FTL (see 5 fusions); CSNK2A1 (see 2 fusions); HNRNPC (see 1 fusions); EZH2 (see 1 fusions); PCNA (see 1 fusions); UBC (see 7 fusions); FECH (see 2 fusions); SDC2 (see 2 fusions); PRPF40A (see 2 fusions); HSBP1 (see 1 fusions); FOXP2 (see 2 fusions); SET (see 1 fusions); CCDC102B (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SDCBPparental protein1880.02047427.496PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
2 MMEparental protein760.02313709.409Peptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
3 ABI2suppressor100.222352.029Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
SH3_9 (PF14604, IPR001452): Variant SH3 domain
TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
4 AESprotein found in more fusions180.191229.327TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
5 AGTinteractor2025.386Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
6 AIMP1suppressor120.80310.899DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal
tRNA_bind (PF01588, IPR002547): Putative tRNA binding domain
7 AIMP2suppressor150.549109.301GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
AIMP2_LysRS_bd (PF16780, IPR031889): AIMP2 lysyl-tRNA synthetase binding domain
8 ALDH3A2interactor30.33353.077Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
9 ANKRD28interactor30.6671.952Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
10 ANKRD40interactor31.0000Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
11 ANP32Boncoprotein60.66734.173FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
SDA1 (PF05285, IPR007949): SDA1
LRR_9 (PF14580): Leucine-rich repeat
12 APIPinteractor40.333300.554Aldolase_II (PF00596, IPR001303, SM01007): Class II Aldolase and Adducin N-terminal domain
13 ARL1interactor21.0000Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
14 ARMC10suppressor100Arm_2 (PF04826, IPR006911): Armadillo-like
15 ATP12Ainteractor100Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
FA_desaturase (PF00487, IPR005804): Fatty acid desaturase
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
16 ATP5J2interactor100WRW (PF10206, IPR019344): Mitochondrial F1F0-ATP synthase, subunit f
17 BCL2L15interactor100Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
18 C11orf57interactor40.50030.925Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
RAMP4 (PF06624, IPR010580): Ribosome associated membrane protein RAMP4
SRP72 (PF08492, IPR013699): SRP72 RNA-binding domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
FAM60A (PF15396, IPR026065): Protein Family FAM60A
RRP14 (PF15459, IPR029188): 60S ribosome biogenesis protein Rrp14
NKAP (PF15692): NF-kappa-B-activating protein
19 C11orf68interactor21.0000DUF1917 (PF08939, IPR015034): Domain of unknown function (DUF1917)
20 C1orf109interactor140.187205.207CK2S (PF15011, IPR029159): Casein Kinase 2 substrate
21 CADPSinteractor21.0000DUF1041 (PF06292, IPR010439, SM01145): Domain of Unknown Function (DUF1041)
MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
PH (PF00169, IPR001849, SM00233): PH domain
Sporozoite_P67 (PF05642, IPR008845): Sporozoite P67 surface antigen
22 CALCOCO2interactor90.321177.368bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
23 CBR3interactor40.50081.397adh_short (PF00106, IPR002198): short chain dehydrogenase
24 CCDC102Bprotein found in more fusions50.5003.067Filament (PF00038, IPR001664): Intermediate filament protein
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
25 CCDC36interactor40.6672.599DUF4700 (PF15771, IPR031529): Domain of unknown function (DUF4700)
26 CCDC53interactor70.28657.841DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
27 CD4suppressor60.4006.142ATP1G1_PLM_MAT8 (PF02038, IPR000272): ATP1G1/PLM/MAT8 family
C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
CD4-extracel (PF09191, IPR015274): CD4, extracellular
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Tcell_CD4_C (PF12104, IPR021963): T cell CD4 receptor C terminal region
28 CD63interactor40.5003.000Tetraspannin (PF00335, IPR018499): Tetraspanin family
DUF4282 (PF14110, IPR025557): Domain of unknown function (DUF4282)
29 CDAoncoprotein100dCMP_cyt_deam_1 (PF00383, IPR002125): Cytidine and deoxycytidylate deaminase zinc-binding region
dCMP_cyt_deam_2 (PF08211, IPR013171): Cytidine and deoxycytidylate deaminase zinc-binding region
30 CDC34oncoprotein40.6673.043UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
31 CDCP1suppressor100CUB (PF00431, IPR000859, SM00042): CUB domain
32 CDIPTinteractor21.0000A2M_N (PF01835, IPR002890): MG2 domain
Dynactin (PF12455, IPR022157): Dynein associated protein
33 CDK5RAP3interactor60.600111.992DUF773 (PF05600, IPR008491): Protein of unknown function (DUF773)
34 CEP170interactor60.40012.571FHA (PF00498, IPR000253, SM00240): FHA domain
DUF4254 (PF14063, IPR025350): Protein of unknown function (DUF4254)
CEP170_C (PF15308, IPR029300): CEP170 C-terminus
35 CEP55interactor80.33320.822DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
ZapB (PF06005, IPR009252): Cell division protein ZapB
EABR (PF12180, IPR022008): TSG101 and ALIX binding domain of CEP55
zf-C2H2_3 (PF13878, IPR028005): zinc-finger of acetyl-transferase ESCO
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
36 CGGBP1interactor40.6673.611AKAP95 (PF04988, IPR007071): A-kinase anchoring protein 95 (AKAP95)
Mei5 (PF10376, IPR018468): Double-strand recombination repair protein
37 CLEC4Minteractor200Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
DUF2730 (PF10805, IPR020269): Protein of unknown function (DUF2730)
38 CLK2interactor70.40023.033DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-met (PF12874): Zinc-finger of C2H2 type
39 CLK3interactor60.4008.142Pkinase (PF00069, IPR000719): Protein kinase domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
40 CMTM5suppressor100MARVEL (PF01284, IPR008253): Membrane-associating domain
DUF2207 (PF09972, IPR018702): Predicted membrane protein (DUF2207)
41 CNOT1interactor30.6671.167Not1 (PF04054, IPR007196): CCR4-Not complex component, Not1
DUF3439 (PF11921, IPR024592): Domain of unknown function (DUF3439)
DUF3819 (PF12842, IPR024557): Domain of unknown function (DUF3819)
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
CNOT1_CAF1_bind (PF16415, IPR032191): CCR4-NOT transcription complex subunit 1 CAF1-binding domain
CNOT1_TTP_bind (PF16417, IPR032193): CCR4-NOT transcription complex subunit 1 TTP binding domain
CNOT1_HEAT (PF16418, IPR032194): CCR4-NOT transcription complex subunit 1 HEAT repeat
42 COX4I1interactor40435.910COX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
43 CPSF6interactor90.222226.807RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
PRIMA1 (PF16101): Proline-rich membrane anchor 1
44 CRYAAoncoprotein3018.631Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
45 CSNK2A1oncoprotein180.118870.697Pkinase (PF00069, IPR000719): Protein kinase domain
46 CT45A3interactor100INT_SG_DDX_CT_C (PF15300, IPR029307): INTS6/SAGE1/DDX26B/CT45 C-terminus
47 CT45A5interactor100INT_SG_DDX_CT_C (PF15300, IPR029307): INTS6/SAGE1/DDX26B/CT45 C-terminus
48 CUTCinteractor200CutC (PF03932, IPR005627): CutC family
49 DARSinteractor160.567257.975tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N)
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
50 DCTDprotein found in more fusions31.0000dCMP_cyt_deam_1 (PF00383, IPR002125): Cytidine and deoxycytidylate deaminase zinc-binding region
51 DCTPP1interactor30104.556MazG-like (PF12643, IPR025984): MazG-like family
52 DMC1interactor200Rad51 (PF08423, IPR013632): Rad51
HHH_5 (PF14520): Helix-hairpin-helix domain
53 DNAJB12interactor21.0000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DUF1977 (PF09320, IPR015399): Domain of unknown function (DUF1977)
TPR_19 (PF14559): Tetratricopeptide repeat
54 DTNBP1interactor50.5004.810Dysbindin (PF04440, IPR007531): Dysbindin (Dystrobrevin binding protein 1)
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
DUF2730 (PF10805, IPR020269): Protein of unknown function (DUF2730)
55 EAF1suppressor50.60012.373Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Peroxin-3 (PF04882, IPR006966): Peroxin-3
EAF (PF09816, IPR019194): RNA polymerase II transcription elongation factor
56 EDARADDinteractor31.0000Death (PF00531, IPR000488, SM00005): Death domain
SCO1-SenC (PF02630, IPR003782): SCO1/SenC
57 EEF1A1suppressor190.209566.679GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
58 EEF1E1suppressor130.67937.385GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
59 EFNB1interactor100Ephrin (PF00812, IPR001799): Ephrin
DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
TMEM132D_C (PF15706, IPR031436): Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
60 EIF1ADinteractor50.50017.071eIF-1a (PF01176, IPR006196): Translation initiation factor 1A / IF-1
61 EIF5A2interactor30.6672.391EFP_N (PF08207, IPR013185): Elongation factor P (EF-P) KOW-like domain
eIF-5a (PF01287, IPR020189): Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold
62 ELAVL1oncoprotein470.0554679.420RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
63 ENOX1interactor100bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Nup35_RRM_2 (PF14605): Nup53/35/40-type RNA recognition motif
GLTSCR1 (PF15249, IPR015671): Conserved region of unknown function on GLTSCR protein
SesA (PF17107, IPR031352): N-terminal domain on NACHT_NTPase and P-loop NTPases
64 EPRSinteractor140.65949.003GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
ProRS-C_1 (PF09180, IPR016061, SM00946): Prolyl-tRNA synthetase, C-terminal
tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain
tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
65 ERICH2interactor100CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
NOA36 (PF06524, IPR010531): NOA36 protein
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
66 EWSR1oncoprotein310.1101728.054RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
67 EZH2suppressor120.255162.749CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
68 FAAHinteractor2059.746Amidase (PF01425, IPR000120): Amidase
69 FAHD1interactor100FAA_hydrolase (PF01557, IPR002529): Fumarylacetoacetate (FAA) hydrolase family
70 FAM118Ainteractor31.0000SIR2_2 (PF13289): SIR2-like domain
71 FAM118Binteractor30.6671.000SIR2_2 (PF13289): SIR2-like domain
72 FAM234Ainteractor100FG-GAP (PF01839, IPR013517): FG-GAP repeat
PQQ_2 (PF13360, IPR002372): PQQ-like domain
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
73 FAM83Finteractor2048.408DUF1669 (PF07894, IPR012461): Protein of unknown function (DUF1669)
74 FAM9Binteractor40.6671.327Cor1 (PF04803, IPR006888): Cor1/Xlr/Xmr conserved region
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
75 FECHprotein found in more fusions3048.408Ferrochelatase (PF00762, IPR001015): Ferrochelatase
76 FLAD1protein found in more fusions40.6671.468MoCF_biosynth (PF00994, IPR001453, SM00852): Probable molybdopterin binding domain
PAPS_reduct (PF01507, IPR002500): Phosphoadenosine phosphosulfate reductase family
77 FLOT2interactor30.33323.884YjbH (PF06082, IPR010344): Exopolysaccharide biosynthesis protein YbjH
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
Flot (PF15975, IPR031905): Flotillin
78 FOLH1interactor100PA (PF02225, IPR003137): PA domain
Peptidase_M28 (PF04389, IPR007484): Peptidase family M28
TFR_dimer (PF04253, IPR007365): Transferrin receptor-like dimerisation domain
UNC-79 (PF14776): Cation-channel complex subunit UNC-79
79 FOXP2protein found in more fusions31.0000Auxin_repressed (PF05564, IPR008406): Dormancy/auxin associated protein
CDC45 (PF02724, IPR003874): CDC45-like protein
Plasmodium_Vir (PF05795, IPR008780): Plasmodium vivax Vir protein
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
Draxin (PF15550, IPR029094): Draxin
SPATA3 (PF15662, IPR026717): Spermatogenesis-associated protein 3 family
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
80 FTH1interactor50.33340.434Coat_F (PF07875, IPR012851): Coat F domain
Ferritin (PF00210, IPR008331): Ferritin-like domain
81 FTLprotein found in more fusions31.0000Ferritin (PF00210, IPR008331): Ferritin-like domain
82 GNMTsuppressor41.0000TehB (PF03848, IPR015985): Tellurite resistance protein TehB
Methyltransf_25 (PF13649): Methyltransferase domain
83 GPATCH11interactor21.0000G-patch (PF01585, IPR000467, SM00443): G-patch domain
DUF2681 (PF10883, IPR020274): Protein of unknown function (DUF2681)
ALMT (PF11744, IPR020966): Aluminium activated malate transporter
DUF4187 (PF13821, IPR025239): Domain of unknown function (DUF4187)
84 GPR37interactor40.333120.8727tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
85 GRIA1interactor40.6672.000ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
Lig_chan (PF00060, IPR001320): Ligand-gated ion channel
Lig_chan-Glu_bd (PF10613, IPR019594, SM00918): Ligated ion channel L-glutamate- and glycine-binding site
86 GRIA2interactor31.0000ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
Lig_chan (PF00060, IPR001320): Ligand-gated ion channel
Lig_chan-Glu_bd (PF10613, IPR019594, SM00918): Ligated ion channel L-glutamate- and glycine-binding site
87 GRIA3interactor100ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
Lig_chan (PF00060, IPR001320): Ligand-gated ion channel
DUF2061 (PF09834, IPR018638): Predicted membrane protein (DUF2061)
Lig_chan-Glu_bd (PF10613, IPR019594, SM00918): Ligated ion channel L-glutamate- and glycine-binding site
88 GRIA4interactor21.0000ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
Lig_chan (PF00060, IPR001320): Ligand-gated ion channel
Lig_chan-Glu_bd (PF10613, IPR019594, SM00918): Ligated ion channel L-glutamate- and glycine-binding site
89 GRIK1interactor100ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
Lig_chan (PF00060, IPR001320): Ligand-gated ion channel
Lig_chan-Glu_bd (PF10613, IPR019594, SM00918): Ligated ion channel L-glutamate- and glycine-binding site
90 GRIK2interactor31.0000ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
Lig_chan (PF00060, IPR001320): Ligand-gated ion channel
Lig_chan-Glu_bd (PF10613, IPR019594, SM00918): Ligated ion channel L-glutamate- and glycine-binding site
91 GRM2interactor1007tm_3 (PF00003, IPR017978): 7 transmembrane sweet-taste receptor of 3 GCPR
ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
92 GRM3interactor1007tm_3 (PF00003, IPR017978): 7 transmembrane sweet-taste receptor of 3 GCPR
ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
93 GRM7interactor1007tm_3 (PF00003, IPR017978): 7 transmembrane sweet-taste receptor of 3 GCPR
ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
DUF2318 (PF10080, IPR018758): Predicted membrane protein (DUF2318)
94 HDAC8interactor30.33383.299DNase-RNase (PF02577, IPR003729): Bifunctional nuclease
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
95 HIST1H2AGinteractor2015.013Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
96 HIST1H2BGoncoprotein30.6675.773Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
97 HIVEP1suppressor40.33340.779PHD (PF00628, IPR019787, SM00249): PHD-finger
PyrI_C (PF02748, IPR020542): Aspartate carbamoyltransferase regulatory chain, metal binding domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_7 (PF15269): Zinc-finger
98 HMGB3interactor30.66772.473HMG_box_2 (PF09011, IPR009071): HMG-box domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
99 HNRNPCprotein found in more fusions110.356144.683APG6 (PF04111, IPR007243): Autophagy protein Apg6
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
100 HOMEZinteractor30.6672.116Homeobox_KN (PF05920, IPR008422): Homeobox KN domain
Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Homez (PF11569, IPR024578): Homeodomain leucine-zipper encoding, Homez
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
PRIMA1 (PF16101): Proline-rich membrane anchor 1
101 HOXA1interactor51.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
102 HPRT1interactor31.0000Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
103 HSBP1protein found in more fusions80.47651.779HSBP1 (PF06825, IPR009643): Heat shock factor binding protein 1
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
104 HSPA1Ainteractor120.212297.081HSP70 (PF00012, IPR013126): Hsp70 protein
105 HSPA4interactor170.125715.215Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
106 HSPA8oncoprotein150.305493.020HSP70 (PF00012, IPR013126): Hsp70 protein
107 HSPB1oncoprotein180.191680.961HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
108 IARSinteractor140.72537.866Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
109 IFI16suppressor60.33310.788HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
110 IKZF1suppressor31.0000Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
111 IL5RAinteractor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding
Tissue_fac (PF01108, IPR003961): Tissue factor
112 IMPDH2protein found in more fusions3063.380IMPDH (PF00478, IPR001093): IMP dehydrogenase / GMP reductase domain
113 INO80Einteractor40.33397.049NBP1 (PF08537, IPR013743): Fungal Nap binding protein NBP1
114 INPP5Dinteractor50.400156.518Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
SH2 (PF00017, IPR000980, SM00252): SH2 domain
115 IRAK2oncoprotein2042.989Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
116 ITGA4interactor310.1632328.189FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
117 KBTBD3interactor100BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_6 (PF13964): Kelch motif
118 KCNH1oncoprotein100Ion_trans (PF00520, IPR005821): Ion transport protein
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
PAS_9 (PF13426, IPR000014): PAS domain
119 KCTD1interactor200BTB_2 (PF02214, IPR003131): BTB/POZ domain
120 KCTD6interactor31.0000BTB_2 (PF02214, IPR003131): BTB/POZ domain
121 KCTD9protein found in more fusions50.66713.866BTB_2 (PF02214, IPR003131): BTB/POZ domain
Pentapeptide (PF00805, IPR001646): Pentapeptide repeats (8 copies)
KHA (PF11834, IPR021789): KHA, dimerisation domain of potassium ion channel
122 KHDRBS2interactor60.300120.066KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
123 KLHL12interactor70.33365.800BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
124 KLHL2interactor40.6671.167BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
125 KRT10interactor40.33374.349Filament (PF00038, IPR001664): Intermediate filament protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
126 KRTAP10-3interactor130.348358.594Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
127 KRTAP10-7interactor110.400303.064Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
128 KRTAP5-9interactor50.9000.500Ery_res_leader2 (PF08057, IPR012559): Erythromycin resistance leader peptide
129 LAMTOR1interactor40.33357.947LAMTOR (PF15454, IPR028209): Late endosomal/lysosomal adaptor and MAPK and MTOR activator
130 LARSinteractor120.87911.359Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
131 LDOC1oncoprotein41.0000DUF4939 (PF16297, IPR032549): Domain of unknown function (DUF4939)
132 LGALS2interactor100Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
133 LGALS8interactor60.40035.987Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
134 LMNAprotein found in more fusions110.2221650.675Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
135 LONP1interactor2015.013AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_PrkA (PF08298, IPR013153, SM00763): PrkA AAA domain
LON_substr_bdg (PF02190, IPR003111, SM00464): ATP-dependent protease La (LON) substrate-binding domain
Lon_C (PF05362, IPR008269): Lon protease (S16) C-terminal proteolytic domain
RuvB_N (PF05496, IPR008824): Holliday junction DNA helicase ruvB N-terminus
AAA_23 (PF13476): AAA domain
136 LSM6interactor100LSM (PF01423, IPR001163): LSM domain
137 LTBRoncoprotein31.0000Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family
138 LYNoncoprotein60.200117.831Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
139 LZTFL1interactor31.0000Leu_zip (PF15294): Leucine zipper
140 MAD2L1oncoprotein200HORMA (PF02301, IPR003511): HORMA domain
141 MAPRE3interactor21.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
142 MARSoncoprotein120.87911.359Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
tRNA-synt_1g (PF09334, IPR015413): tRNA synthetases class I (M)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
GST_N_2 (PF13409, IPR004045): Glutathione S-transferase, N-terminal domain
143 MBD3interactor70.40024.281DUF2201_N (PF13203, IPR025154): Putative metallopeptidase domain
144 MED4interactor140.198356.028Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
145 METTL7Ainteractor2048.408Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain
146 MID2interactor70.4676.967fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
147 MRFAP1L1interactor41.0000MRFAP1 (PF15155, IPR029254): MORF4 family-associated protein1
148 MRPL44interactor20104.836dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Ribonuclease_3 (PF00636, IPR000999, SM00535): Ribonuclease III domain
149 MRPS25interactor21.0000L51_S25_CI-B8 (PF05047, IPR007741, SM00916): Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
150 MRVI1suppressor100MRVI1 (PF05781, IPR008677): MRVI1 protein
151 MTDHinteractor30.6670.883NST1 (PF13945, IPR025279): Salt tolerance down-regulator
NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
LYRIC (PF15686, IPR031402): Lysine-rich CEACAM1 co-isolated protein family
152 MTHFD1interactor50.200133.320FTHFS (PF01268, IPR000559): Formate--tetrahydrofolate ligase
THF_DHG_CYH (PF00763, IPR020630): Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
THF_DHG_CYH_C (PF02882, IPR020631): Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
153 MTUS2suppressor50.8330.500DUF496 (PF04363, IPR007458): Protein of unknown function (DUF496)
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
FAM184 (PF15665): Family with sequence similarity 184, A and B
154 MYH9suppressor60.40041.263IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
155 NADKinteractor100NAD_kinase (PF01513, IPR002504): ATP-NAD kinase
156 NAGKprotein found in more fusions31.0000BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family
157 NDRG1suppressor50.20079.456Ndr (PF03096, IPR004142): Ndr family
158 NDUFA10interactor30.33331.345dNK (PF01712, IPR002624): Deoxynucleoside kinase
159 NDUFA9interactor70.333284.562Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family
160 NDUFB4interactor21.0000NDUF_B4 (PF07225, IPR009866): NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)
161 NECAB2interactor50.5003.547ABM (PF03992, IPR007138): Antibiotic biosynthesis monooxygenase
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
162 NF2suppressor100.167270.168ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
163 NNTinteractor21.0000AlaDh_PNT_C (PF01262, IPR007698, SM01002): Alanine dehydrogenase/PNT, C-terminal domain
AlaDh_PNT_N (PF05222, IPR007886, SM01003): Alanine dehydrogenase/PNT, N-terminal domain
PNTB (PF02233, IPR012136): NAD(P) transhydrogenase beta subunit
PNTB_4TM (PF12769, IPR024605): 4TM region of pyridine nucleotide transhydrogenase, mitoch
164 NOLC1interactor30.6676.154DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
SRP40_C (PF05022, IPR007718): SRP40, C-terminal domain
Stm1_N (PF09598, IPR019084): Stm1
stn_TNFRSF12A (PF12191, IPR022316): Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain
NST1 (PF13945, IPR025279): Salt tolerance down-regulator
SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
PAF (PF15715, IPR031444): PCNA-associated factor
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
NuDC (PF16273, IPR032572): Nuclear distribution C domain
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
165 NOTCH2NLinteractor110.382463.255EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
166 NPPAinteractor100ANP (PF00212, IPR000663, SM00183): Atrial natriuretic peptide
167 NT5C2protein found in more fusions2005_nucleotid (PF05761, IPR008380): 5' nucleotidase family
168 NUCKS1interactor40.333146.244FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
169 OPA1interactor40.33372.012DUF1593 (PF07632, IPR011483): Protein of unknown function (DUF1593)
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
IncA (PF04156, IPR007285): IncA protein
Ras (PF00071, IPR001806, SM00173): Ras family
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
DUF4061 (PF13270, IPR025271): Domain of unknown function (DUF4061)
170 OSTF1interactor40.5009.441SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
171 PCNAoncoprotein90.214323.033PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
172 PDCD6IPinteractor90.35750.681BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
173 PDE4DIPoncoprotein50.50021.780ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1220 (PF06758, IPR010630, SM01148): Repeat of unknown function (DUF1220)
DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515)
IncA (PF04156, IPR007285): IncA protein
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
Nup54 (PF13874, IPR025712): Nucleoporin complex subunit 54
FAM76 (PF16046, IPR032017): FAM76 protein
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
174 PDIA5interactor30.33384.586Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
175 PHC2interactor60.40011.375SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
zf-CGNR (PF11706, IPR021005): CGNR zinc finger
DUF4692 (PF15763, IPR031517): Domain of unknown function (DUF4692)
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
176 PNMA1oncoprotein21.0000PNMA (PF14893, IPR026523): PNMA
177 PNMA2interactor21.0000PNMA (PF14893, IPR026523): PNMA
178 POTEIinteractor100Actin (PF00022, IPR004000, SM00268): Actin
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
DUF3641 (PF12345, IPR024521): Protein of unknown function (DUF3641)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
CCDC144C (PF14915): CCDC144C protein coiled-coil region
179 PPP6R2interactor40.167227.387SAMP (PF05924, IPR009224): SAMP Motif
SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
180 PRPF38Ainteractor70.40054.712PRP38 (PF03371, IPR005037): PRP38 family
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
181 PRPF40Aprotein found in more fusions110.267162.973FF (PF01846, IPR002713, SM00441): FF domain
MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain
Transformer (PF06495, IPR010519): Fruit fly transformer protein
WW (PF00397, IPR001202, SM00456): WW domain
YqzE (PF14038, IPR025622): YqzE-like protein
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus
SOBP (PF15279, IPR026092): Sine oculis-binding protein
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
182 PRR13interactor80.28627.897DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
183 PSMC6interactor100.361124.281AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
184 PSTPIP1interactor40.16760.706ABATE (PF07336, IPR010852): Putative stress-induced transcription regulator
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
WXG100 (PF06013, IPR010310): Proteins of 100 residues with WXG
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
185 PTENsuppressor100.156611.953DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
186 PTPRJsuppressor31.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Interfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
Syndecan (PF01034, IPR027789): Syndecan domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
187 PTSprotein found in more fusions200PTPS (PF01242, IPR007115): 6-pyruvoyl tetrahydropterin synthase
188 PUF60protein found in more fusions100.306115.423RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Titin_Z (PF09042, IPR015129): Titin Z
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
189 PYCRLinteractor200F420_oxidored (PF03807, IPR028939): NADP oxidoreductase coenzyme F420-dependent
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
P5CR_dimer (PF14748, IPR029036): Pyrroline-5-carboxylate reductase dimerisation
190 QARSinteractor130.64126.306tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain
tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain
tRNA_synt_1c_R1 (PF04558, IPR007639): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1
tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
191 RAB5Aoncoprotein50.50015.054Ras (PF00071, IPR001806, SM00173): Ras family
192 RAP2Boncoprotein40.167113.109Ras (PF00071, IPR001806, SM00173): Ras family
193 RARSinteractor130.74424.102Arg_tRNA_synt_N (PF03485, IPR005148, SM01016): Arginyl tRNA synthetase N terminal domain
DALR_1 (PF05746, IPR008909, SM00836): DALR anticodon binding domain
DivIC (PF04977, IPR007060): Septum formation initiator
tRNA-synt_1d (PF00750, IPR015945): tRNA synthetases class I (R)
Mto2_bdg (PF12808, IPR024545): Micro-tubular organiser Mto1 C-term Mto2-binding region
194 RBM39oncoprotein190.1642023.790RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
195 REEP6interactor200TB2_DP1_HVA22 (PF03134, IPR004345): TB2/DP1, HVA22 family
196 RELoncoprotein120.167200.586RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
197 RGPD6interactor100GRIP (PF01465, IPR000237, SM00755): GRIP domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
FlxA (PF14282, IPR025577): FlxA-like protein
TPR_19 (PF14559): Tetratricopeptide repeat
Rab_bind (PF16704, IPR032023): Rab binding domain
198 RIC8Ainteractor21.0000PUL (PF08324, IPR013535): PUL domain
Ric8 (PF10165, IPR019318): Guanine nucleotide exchange factor synembryn
199 RNH1suppressor100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
Metallothio_Euk (PF12749, IPR024306): Eukaryotic metallothionein
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
200 ROPN1interactor200RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
201 RP9Pprotein found in more fusions50.6673.843NA
202 RPL30interactor70.52490.154NCBP3 (PF10309, IPR019416): Nuclear cap-binding protein subunit 3
203 RPS10interactor80.357255.665S10_plectin (PF03501, IPR005326): Plectin/S10 domain
204 RPS23interactor50.6009.265Ribosom_S12_S23 (PF00164, IPR006032): Ribosomal protein S12/S23
205 RTN1interactor20259.154Reticulon (PF02453, IPR003388): Reticulon
206 RUNDC3Ainteractor2085.851Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20
RUN (PF02759, IPR004012, SM00593): RUN domain
207 RUVBL1oncoprotein150.198399.912TIP49 (PF06068, IPR010339): TIP49 C-terminus
208 RUVBL2oncoprotein100.278182.049TIP49 (PF06068, IPR010339): TIP49 C-terminus
209 SAMD1interactor30.66711.163CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
PRIMA1 (PF16101): Proline-rich membrane anchor 1
210 SCLT1oncoprotein50.50042.112DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
SlyX (PF04102, IPR007236): SlyX
XhlA (PF10779, IPR019715): Haemolysin XhlA
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Imm7 (PF15585, IPR028965): Immunity protein 7
CCCAP (PF15964, IPR031887): Centrosomal colon cancer autoantigen protein family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
211 SDC1oncoprotein30.6673.706Herpes_TAF50 (PF03326, IPR004998): Herpesvirus transcription activation factor (transactivator)
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3592 (PF12158, IPR021994): Protein of unknown function (DUF3592)
AJAP1_PANP_C (PF15298, IPR029198): AJAP1/PANP C-terminus
212 SDC2protein found in more fusions31.0000Glycophorin_A (PF01102, IPR001195): Glycophorin A
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
213 SDCCAG3interactor50.50026.130GA (PF01468, IPR002988, SM00844): GA module
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
214 SDF4interactor100Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
215 SEPT3interactor200Septin (PF00735, IPR000038): Septin
216 SEToncoprotein40.6676.919NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
Nop14 (PF04147, IPR007276): Nop14-like family
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
217 SIAH1suppressor90.25021.087Sina (PF03145, IPR018121): Seven in absentia protein family
218 SLC16A1oncoprotein2017.378MFS_1 (PF07690, IPR011701): Major Facilitator Superfamily
219 SLC9A3R1suppressor50134.183EBP50_C (PF09007, IPR015098): EBP50, C-terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
220 SMARCA2suppressor40.16745.998DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168)
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
YL1 (PF05764, IPR008895): YL1 nuclear protein
BRK (PF07533, IPR006576, SM00592): BRK domain
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
221 SOX4oncoprotein21.0000Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
MRI (PF15325, IPR028278): Modulator of retrovirus infection
DUF4685 (PF15737, IPR032756): Domain of unknown function (DUF4685)
222 SREK1IP1interactor31.0000zf-CCHC_3 (PF13917): Zinc knuckle
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
223 SRSF11interactor90.3891215.089Rtf2 (PF04641, IPR027799): Rtf2 RING-finger
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TP2 (PF01254, IPR000678): Nuclear transition protein 2
Transformer (PF06495, IPR010519): Fruit fly transformer protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
224 SRSF7interactor60.60016.100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TP2 (PF01254, IPR000678): Nuclear transition protein 2
zf-CCHC (PF00098, IPR001878): Zinc knuckle
225 SSNA1protein found in more fusions31.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
226 SSR4interactor4099.122TRAP-delta (PF05404, IPR008855): Translocon-associated protein, delta subunit precursor (TRAP-delta)
OppC_N (PF12911, IPR025966): N-terminal TM domain of oligopeptide transport permease C
227 SULT1B1interactor100Sulfotransfer_1 (PF00685, IPR000863): Sulfotransferase domain
228 TARSL2interactor21.0000HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
TGS (PF02824, IPR004095): TGS domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
229 TDO2interactor31.0000Trp_dioxygenase (PF03301, IPR004981): Tryptophan 2,3-dioxygenase
230 TEKT1interactor100CI-B14_5a (PF07347, IPR009947): NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
Tektin (PF03148, IPR000435): Tektin family
231 TFCP2interactor40.5004.214CP2 (PF04516, IPR007604): CP2 transcription factor
DUF2967 (PF11179, IPR021349): Protein of unknown function (DUF2967)
232 THG1Linteractor31.0000Thg1 (PF04446, IPR024956): tRNAHis guanylyltransferase
Thg1C (PF14413, IPR025845): Thg1 C terminal domain
233 TIFAinteractor50.50013.277FHA (PF00498, IPR000253, SM00240): FHA domain
234 TKFCinteractor30.333102.843Dak1 (PF02733, IPR004006): Dak1 domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
235 TM9SF1interactor100EMP70 (PF02990, IPR004240): Endomembrane protein 70
236 TMEM239interactor100TMEM239 (PF15841, IPR031694): Transmembrane protein 239 family
237 TNFAIP8interactor50.4007.232DUF758 (PF05527, IPR008477): Domain of unknown function (DUF758)
NiFeSe_Hases (PF00374, IPR001501): Nickel-dependent hydrogenase
238 TNPO1interactor30.33328.045Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
239 TRAF5interactor60.40023.677Sina (PF03145, IPR018121): Seven in absentia protein family
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
240 TRAF6protein found in more fusions130.167536.537SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
241 TRIM27oncoprotein160.200123.181IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
242 TRIM32suppressor80.47622.609NHL (PF01436, IPR001258): NHL repeat
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
243 TRIM38interactor60.300113.136DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
244 TRIM54interactor80.23862.456DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
zf-HIT (PF04438, IPR007529): HIT zinc finger
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
245 TSPAN3interactor30.6675.160Hum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein
Tetraspannin (PF00335, IPR018499): Tetraspanin family
246 TUBB8interactor100Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
247 UBAC2interactor30.33395.929Rhomboid (PF01694, IPR022764): Rhomboid family
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
248 UBCprotein found in more fusions310.1311824.652ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
249 UBE2Ainteractor60.400127.120UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
250 ULK1protein found in more fusions31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
251 UNKinteractor80.107617.747MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
252 UTRNprotein found in more fusions40111.824bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
EF-hand_2 (PF09068, IPR015153): EF hand
EF-hand_3 (PF09069, IPR015154): EF-hand
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
WW (PF00397, IPR001202, SM00456): WW domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
253 VCAM1interactor280.2121427.344C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
254 VDAC2interactor80.214258.463Porin_3 (PF01459, IPR027246): Eukaryotic porin
255 WASLinteractor50.40017.624Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
256 WRAP73interactor60.300186.216eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
IKI3 (PF04762, IPR006849): IKI3 family
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2555 (PF10742, IPR019678): Protein of unknown function (DUF2555)
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
257 XRCC5suppressor130.288187.012Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like
258 ZBTB14interactor60.6007.295BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
259 ZBTB8Ainteractor40.6670.869BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
260 ZCCHC10interactor120.182209.710Macoilin (PF09726, IPR019130): Transmembrane protein
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
zf-CCHC_3 (PF13917): Zinc knuckle
261 ZCCHC17interactor100S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
262 ZMPSTE24interactor2048.408Peptidase_M48 (PF01435, IPR001915): Peptidase family M48
Peptidase_M48_N (PF16491, IPR032456): CAAX prenyl protease N-terminal, five membrane helices

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