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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins LOC105371743, CCL5 (from a repository: Thu Aug 29 17:55:25 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins9 (32.14 %)
The number (and %) of the tumor suppressors8 (28.57 %)
Total number of binary PPIs (saturation %)40 (10.58 %)
The number (and %) of affected PPIs26 (65.00 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI2.286
Assortativity coefficient-0.4956
The network average Clustering coefficient0.274
The number (and %) of a zero Clustering coefficients19 (67.86 %)
The number (and %) of a zero Betweenness Centrality26 (92.86 %)


List of the fusions

PPI for parental proteins: CCL5,LOC105371743 All fusions
Proteins found in more fusions APC (see 1 fusions); CXCL8 (see 3 fusions); RANGAP1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 CCL5parental protein260.018637.000IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
2 LOC105371743interactor000NA
3 ACKR2interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4 APCsuppressor200APC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
5 BAG4interactor100BAG (PF02179, IPR003103, SM00264): BAG domain
DMP12 (PF16779, IPR031891): DNA-mimic protein
6 BCAR3oncoprotein100RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
7 CCL2interactor40.6671.000IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
8 CCR1oncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
9 CCR3interactor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
10 CCR4interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
11 CCR5interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
12 CHEK2suppressor200FHA (PF00498, IPR000253, SM00240): FHA domain
Pkinase (PF00069, IPR000719): Protein kinase domain
13 CXCL8protein found in more fusions31.0000IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
14 EDC4interactor100DUF445 (PF04286, IPR007383): Protein of unknown function (DUF445)
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
DUF2756 (PF10956, IPR020158): Protein of unknown function (DUF2756)
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
15 FZR1suppressor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
16 KRASoncoprotein41.0000Ras (PF00071, IPR001806, SM00173): Ras family
17 PALB2suppressor200IncA (PF04156, IPR007285): IncA protein
PALB2_WD40 (PF16756, IPR031920): Partner and localizer of BRCA2 WD40 domain
18 PHBsuppressor31.0000Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
19 PTPN1suppressor31.0000Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
20 RANGAP1protein found in more fusions200RanGAP1_C (PF07834, IPR009109): RanGAP1 C-terminal domain
SDA1 (PF05285, IPR007949): SDA1
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
21 RELAoncoprotein200DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
22 SDC1oncoprotein21.0000Herpes_TAF50 (PF03326, IPR004998): Herpesvirus transcription activation factor (transactivator)
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3592 (PF12158, IPR021994): Protein of unknown function (DUF3592)
AJAP1_PANP_C (PF15298, IPR029198): AJAP1/PANP C-terminus
23 SDC4oncoprotein100Syndecan (PF01034, IPR027789): Syndecan domain
24 SLC2A5interactor100Sugar_tr (PF00083, IPR005828): Sugar (and other) transporter
25 TGFB1suppressor100TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
26 TRIP6interactor100DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
LIM (PF00412, IPR001781, SM00132): LIM domain
27 VCANoncoprotein21.0000EGF (PF00008, IPR000742, SM00181): EGF-like domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
Xlink (PF00193, IPR000538, SM00445): Extracellular link domain
28 WT1suppressor100WT1 (PF02165, IPR000976): Wilm's tumour protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
CCAP (PF11105, IPR024276): Arthropod cardioacceleratory peptide 2a
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain

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