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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)60
The number (and %) of the onco-proteins18 (30.00 %)
The number (and %) of the tumor suppressors9 (15.00 %)
Total number of binary PPIs (saturation %)239 (13.50 %)
The number (and %) of affected PPIs58 (24.27 %)
The number of possible different fusions16
PPI diameter4
PPI radius2
The average degree of PPI7.033
Assortativity coefficient-0.2039
The network average Clustering coefficient0.527
The number (and %) of a zero Clustering coefficients12 (20.00 %)
The number (and %) of a zero Betweenness Centrality24 (40.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ATXN2,IFITM1 All fusions
Proteins found in more fusions TSG101 (see 2 fusions); RBFOX2 (see 3 fusions); ACTN1 (see 3 fusions); DDX17 (see 4 fusions); KHDRBS1 (see 1 fusions); PABPC1 (see 3 fusions); CUL3 (see 1 fusions); ATXN1 (see 3 fusions); DDX5 (see 1 fusions); SH3KBP1 (see 1 fusions); PARK2 (see 1 fusions); EGFR (see 2 fusions); VHL (see 1 fusions); ACTN2 (see 1 fusions); SH3GL2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ATXN2parental protein540.1002325.976LsmAD (PF06741, IPR009604): LsmAD domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Spt20 (PF12090, IPR021950): Spt20 family
SM-ATX (PF14438, IPR025852): Ataxin 2 SM domain
2 IFITM1parental protein40.5008.972CD225 (PF04505, IPR007593): Interferon-induced transmembrane protein
3 ABHD16Ainteractor2017.230Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
4 ACTN1protein found in more fusions80.23866.517CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
5 ACTN2protein found in more fusions31.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
6 ADAinteractor100A_deaminase (PF00962, IPR001365): Adenosine/AMP deaminase
7 ATXN1protein found in more fusions41.0000AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
8 BAG6interactor50.6672.000DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
9 BCAT1interactor100Aminotran_4 (PF01063, IPR001544): Amino-transferase class IV
10 BMI1oncoprotein100.47214.113zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
11 CAND1interactor180.50041.144Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
12 CARD8oncoprotein100CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
FIIND (PF13553, IPR025307): Function to find
13 CCNDBP1suppressor100CheF-arch (PF04283, IPR007381): Chemotaxis signal transduction system protein F from archaea
GCIP (PF13324): Grap2 and cyclin-D-interacting
14 CCT5interactor40.6670.800Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
15 CD19interactor31.0000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
16 CD81interactor100.278317.916Tetraspannin (PF00335, IPR018499): Tetraspanin family
17 CELA2Binteractor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
18 CHGBinteractor21.0000Granin (PF01271, IPR001990): Granin (chromogranin or secretogranin)
19 CR2oncoprotein31.0000C_tripleX (PF02363, IPR003341): Cysteine rich repeat
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
TIL (PF01826, IPR002919): Trypsin Inhibitor like cysteine rich domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
20 CUL3protein found in more fusions200.45655.766Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
21 DDX17protein found in more fusions160.43891.659CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Ferritin (PF00210, IPR008331): Ferritin-like domain
GRP (PF07172, IPR010800): Glycine rich protein family
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
22 DDX5oncoprotein170.50096.889DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
P68HR (PF08061, IPR012587): P68HR (NUC004) repeat
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
23 DDX6oncoprotein80.6434.210DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
24 DHX15interactor130.59065.986DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
AAA_29 (PF13555): P-loop containing region of AAA domain
25 EGFRoncoprotein80.4768.817Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
26 FGL1interactor100Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
27 GFI1Boncoprotein30.6672.107zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
28 GOLGA6L5Pinteractor100NA
29 GPKOWinteractor21.0000KOW (PF00467, IPR005824, SM00739): KOW motif
G-patch_2 (PF12656, IPR026822): G-patch domain
30 IDH3Binteractor50.6002.822Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
31 ISG15suppressor40.6671.167ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
32 KHDRBS1protein found in more fusions140.50079.115KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
33 KHDRBS2interactor80.6194.036KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
34 KHDRBS3interactor50.8330.500KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
35 KIF1BPinteractor21.0000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
KBP_C (PF12309, IPR022083): KIF-1 binding protein C terminal
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
36 LSM12interactor60.7334.000AD (PF09793, IPR019181, SM00995): Anticodon-binding domain
37 MDC1suppressor21.0000FHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
38 MOV10interactor110.49112.175AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
39 NCOA4suppressor100ARA70 (PF12489, IPR022174): Nuclear coactivator
40 NTRK1oncoprotein240.304149.519I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
41 NXF1interactor130.394133.669NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
42 PABPC1oncoprotein120.49167.471RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
YflT (PF11181, IPR025889): Heat induced stress protein YflT
43 PABPC4interactor110.5459.037ApbA_C (PF08546, IPR013752): Ketopantoate reductase PanE/ApbA C terminal
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
HHV-5_US34A (PF17087, IPR031384): Herpesvirus US34A protein family
44 PARK2suppressor70.5338.684IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
45 RBFOX1interactor41.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Fox-1_C (PF12414, IPR025670): Calcitonin gene-related peptide regulator C terminal
46 RBFOX2protein found in more fusions90.57114.460RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Fox-1_C (PF12414, IPR025670): Calcitonin gene-related peptide regulator C terminal
47 RPL10suppressor90.8332.083Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
48 SEC16Ainteractor50.8000.500APC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
49 SH3GL2oncoprotein51.0000BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
50 SH3GL3interactor51.0000BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
51 SH3KBP1protein found in more fusions120.32733.890Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
52 SHFM1interactor21.0000CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
53 SKAP1interactor200PH (PF00169, IPR001849, SM00233): PH domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
54 TARDBPinteractor190.43852.648RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
55 TDRD7interactor200TUDOR (PF00567, IPR002999, SM00333): Tudor domain
OST-HTH (PF12872, IPR025605): OST-HTH/LOTUS domain
56 TSG101suppressor110.42216.850APG6 (PF04111, IPR007243): Autophagy protein Apg6
Laminin_II (PF06009, IPR010307): Laminin Domain II
UEV (PF05743, IPR008883): UEV domain
Vps23_core (PF09454, IPR017916): Vps23 core domain
57 VHLsuppressor60.7002.322Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain
58 WWOXsuppressor70.6192.950adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain
59 YEATS4interactor100YEATS (PF03366, IPR005033): YEATS family
SOGA (PF11365, IPR027881): Protein SOGA
60 ZNRD1interactor21.0000RecR (PF02132, IPR023628): RecR protein
RNA_POL_M_15KD (PF02150, IPR001529): RNA polymerases M/15 Kd subunit
TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS)

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