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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)80
The number (and %) of the onco-proteins16 (20.00 %)
The number (and %) of the tumor suppressors14 (17.50 %)
Total number of binary PPIs (saturation %)437 (13.83 %)
The number (and %) of affected PPIs80 (18.31 %)
The number of possible different fusions16
PPI diameter4
PPI radius2
The average degree of PPI10.000
Assortativity coefficient-0.2552
The network average Clustering coefficient0.477
The number (and %) of a zero Clustering coefficients6 (7.50 %)
The number (and %) of a zero Betweenness Centrality14 (17.50 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: AQR,S100A8 All fusions
Proteins found in more fusions NF2 (see 1 fusions); APP (see 4 fusions); BAG3 (see 4 fusions); S100A8 (see 3 fusions); MCM2 (see 1 fusions); RALYL (see 1 fusions); COPS5 (see 1 fusions); SHC1 (see 1 fusions); WDR77 (see 1 fusions); GRB2 (see 1 fusions); DHX8 (see 1 fusions); USF2 (see 1 fusions); TP53 (see 3 fusions); SUZ12 (see 2 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AQRparental protein360.249789.776AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
Mif2_N (PF15624, IPR028929): Kinetochore CENP-C fungal homologue, Mif2, N-terminal
Aquarius_N (PF16399, IPR032174): Intron-binding protein aquarius N-terminus
2 S100A8parental protein440.0901946.285S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
3 APPprotein found in more fusions200.146382.435APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 ASB3interactor21.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
5 BAG3oncoprotein90.32155.195BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
6 BECN1suppressor303.599APG6 (PF04111, IPR007243): Autophagy protein Apg6
Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain
BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
7 BLMsuppressor110.26761.680BDHCT (PF08072, IPR012532): BDHCT (NUC031) domain
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
HRDC (PF00570, IPR002121, SM00341): HRDC domain
RQC (PF09382, IPR018982, SM00956): RQC domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
ALMT (PF11744, IPR020966): Aluminium activated malate transporter
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
BLM_N (PF16202, IPR032437): N-terminal region of Bloom syndrome protein
BDHCT_assoc (PF16204, IPR032439): BDHCT-box associated domain on Bloom syndrome protein
8 BMI1oncoprotein140.359133.552zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
9 C14orf1interactor208.049Erg28 (PF03694, IPR005352): Erg28 like protein
10 CCDC94interactor60.9330.208DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
11 CDK2suppressor150.45175.143Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
12 CDKN1Asuppressor90.36146.565CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
13 CHGBinteractor40.6671.987Granin (PF01271, IPR001990): Granin (chromogranin or secretogranin)
14 COPS5protein found in more fusions130.39454.806JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
15 CRNKL1interactor230.403158.977NRDE-2 (PF08424, IPR013633): NRDE-2, necessary for RNA interference
HAT (PF02184, IPR003107, SM00386): HAT (Half-A-TPR) repeat
Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Suf (PF05843, IPR008847): Suppressor of forked protein (Suf)
U3_assoc_6 (PF08640, IPR013949): U3 small nucleolar RNA-associated protein 6
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
16 DHX8protein found in more fusions130.53050.901DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
17 DMWDinteractor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
18 EIF4A3interactor240.368277.764DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
19 ESR1suppressor160.314103.656Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
20 GDF9interactor21.0000CAMSAP_CKK (PF08683, IPR014797, SM01051): Microtubule-binding calmodulin-regulated spectrin-associated
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
21 GRB2oncoprotein100.38956.010SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
22 HNRNPA1interactor210.368141.396RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
23 IGSF21interactor21.0000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
24 ISY1interactor180.38265.169Isy1 (PF06246, IPR009360): Isy1-like splicing family
25 ISY1-RAB43interactor60.8000.905Isy1 (PF06246, IPR009360): Isy1-like splicing family
26 LGR4interactor301.1027tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
27 LRIF1interactor70.40022.601LRIF1 (PF15741, IPR026191): Ligand-dependent nuclear receptor-interacting factor 1
28 LRRK1interactor50.6672.000Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
29 MAGOHinteractor180.412109.840Mago_nashi (PF02792, IPR004023): Mago nashi protein
30 MCM2oncoprotein150.363125.476AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
31 MCM5oncoprotein100.37834.114MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
32 MOB1Asuppressor21.0000Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
33 NCF2interactor21.0000PB1 (PF00564, IPR000270, SM00666): PB1 domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
TPR_16 (PF13432): Tetratricopeptide repeat
34 NF2suppressor40.3335.613ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
35 NTRK1oncoprotein230.255319.957I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
36 NUAK1suppressor30.6670.554Pkinase (PF00069, IPR000719): Protein kinase domain
37 NXF1interactor190.301187.924NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
38 OBSL1interactor210.300131.927BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
39 PAXIP1interactor60.33320.149BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
40 PDCD11interactor100.178106.104DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
Suf (PF05843, IPR008847): Suppressor of forked protein (Suf)
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
41 POT1interactor51.0000POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
42 PPIAinteractor110.50936.779Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
43 PPIEinteractor140.51643.337Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
44 PPM1Binteractor50.40037.378PP2C (PF00481, IPR001932): Protein phosphatase 2C
PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain
45 PPP4R1interactor21.0000HEAT (PF02985, IPR000357): HEAT repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_2 (PF13646): HEAT repeats
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
46 PQBP1interactor80.17995.457WW (PF00397, IPR001202, SM00456): WW domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
47 PRMT1interactor180.316181.351Methyltransf_25 (PF13649): Methyltransferase domain
48 PTENsuppressor60.40020.710DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
49 RALYLprotein found in more fusions60.7000.758RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TFIIIC_sub6 (PF10419, IPR019481): TFIIIC subunit
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
50 RBM22interactor100.40021.122FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Torus (PF16131, IPR032297): Torus domain
51 RBM4suppressor90.44425.622RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
CompInhib_SCIN (PF11546, IPR021612): Staphylococcal complement inhibitor SCIN
52 RNF2interactor160.371150.402zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
53 S100A9oncoprotein160.200249.442S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
54 SF3A2interactor90.44425.623Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32
PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like
Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
zf-met (PF12874): Zinc-finger of C2H2 type
ARL6IP6 (PF15062, IPR029383): Haemopoietic lineage transmembrane helix
SF3A2 (PF16835, IPR031781): Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)
55 SHC1oncoprotein100.30664.023PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
56 SHMT2interactor90.30641.022SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
57 SIRT6suppressor21.0000SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
58 SIRT7interactor120.333217.210DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
59 SLX1Binteractor100GIY-YIG (PF01541, IPR000305, SM00465): GIY-YIG catalytic domain
FANCL_C (PF11793, IPR026850): FANCL C-terminal domain
60 SNIP1interactor80.6794.463FHA (PF00498, IPR000253, SM00240): FHA domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
FAM176 (PF14851): FAM176 family
61 SNRNP40interactor110.61831.900WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
62 SNRPA1interactor100.57826.583LRR_9 (PF14580): Leucine-rich repeat
63 SNW1protein found in more fusions280.336307.530SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
64 SUZ12suppressor190.373118.203DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
65 TERF1interactor90.39332.550TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
66 TERF2interactor90.35740.631Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
67 TFAP4oncoprotein40.5005.185DivIC (PF04977, IPR007060): Septum formation initiator
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF2407 (PF10302, IPR019413): DUF2407 ubiquitin-like domain
68 TP53suppressor170.283186.342DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
69 TRAF3IP1interactor21.0000MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
70 TSSC4suppressor90.55652.239TSSC4 (PF15264, IPR029338): Tumour suppressing sub-chromosomal transferable candidate 4
71 TUBGCP3interactor60.40036.752Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
72 UBASH3Binteractor41.0000His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily
SH3_9 (PF14604, IPR001452): Variant SH3 domain
73 UNC119interactor21.0000GMP_PDE_delta (PF05351, IPR008015): GMP-PDE, delta subunit
74 USB1interactor80.7861.876HVSL (PF09749, IPR027521): Uncharacterised conserved protein
75 USF2protein found in more fusions40.6671.307DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
76 USP28interactor200TPR_3 (PF07720, IPR011716): Tetratricopeptide repeat
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
UBA_4 (PF14555): UBA-like domain
DUF4769 (PF15992, IPR031934): Domain of unknown function (DUF4769)
77 WDR77oncoprotein100.36137.601LT-IIB (PF06453, IPR010503): Type II heat-labile enterotoxin , B subunit (LT-IIB)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
78 WDR83interactor90.8332.552WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
79 XAB2interactor210.419134.301NRDE-2 (PF08424, IPR013633): NRDE-2, necessary for RNA interference
HAT (PF02184, IPR003107, SM00386): HAT (Half-A-TPR) repeat
Suf (PF05843, IPR008847): Suppressor of forked protein (Suf)
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
80 ZNF830interactor40.8330.333Sec34 (PF04136, IPR007265): Sec34-like family
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding

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