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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RXRB, AC016526.4 (from a repository: Mon Mar 9 03:06:48 2020)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)37
The number (and %) of the onco-proteins15 (40.54 %)
The number (and %) of the tumor suppressors8 (21.62 %)
Total number of binary PPIs (saturation %)75 (11.26 %)
The number (and %) of affected PPIs35 (46.67 %)
The number of possible different fusions7
PPI diameter2
PPI radiusinf
The average degree of PPI3.459
Assortativity coefficient-0.5650
The network average Clustering coefficient0.361
The number (and %) of a zero Clustering coefficients19 (51.35 %)
The number (and %) of a zero Betweenness Centrality26 (70.27 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: AC016526.4,RXRB All fusions
Proteins found in more fusions RARA (see 1 fusions); PPARD (see 1 fusions); TXLNA (see 3 fusions); NR3C1 (see 8 fusions); VDR (see 2 fusions); NCOA1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AC016526.4interactor000NA
2 RXRBparental protein350.0491051.056zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
3 AFF4oncoprotein100AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
4 AKAP13oncoprotein21.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
IncA (PF04156, IPR007285): IncA protein
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
RII_binding_1 (PF10522, IPR018459): RII binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
5 C2CD5oncoprotein100C2 (PF00168, IPR000008, SM00239): C2 domain
YbjQ_1 (PF01906, IPR002765): Putative heavy-metal-binding
6 CACNA1Binteractor100Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Ion_trans (PF00520, IPR005821): Ion transport protein
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
7 CCNKinteractor100Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
8 CDC42BPBinteractor100CNH (PF00780, IPR001180, SM00036): CNH domain
DMPK_coil (PF08826, IPR014930): DMPK coiled coil domain like
PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
XkdW (PF09636, IPR019094): XkdW protein
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
9 CDC5Linteractor200OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
10 FLYWCH2interactor100FLYWCH_N (PF15423, IPR029279): FLYWCH-type zinc finger-containing protein
11 GRK2interactor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
12 GTF2H1oncoprotein100BSD (PF03909, IPR005607, SM00751): BSD domain
PH_TFIIH (PF08567, IPR013876): TFIIH p62 subunit, N-terminal domain
13 MAP4oncoprotein100SdiA-regulated (PF06977, IPR009722): SdiA-regulated
Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
14 MCATinteractor100Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain
15 MRPS10interactor100Ribosomal_S10 (PF00338, IPR027486): Ribosomal protein S10p/S20e
16 NCOA1oncoprotein140.23151.833DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
17 NR1H2oncoprotein50.8000.722zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
18 NR1H3interactor50.8000.722zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
19 NR1I2suppressor21.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
20 NR2C2suppressor200Flagellin_N (PF00669, IPR001029): Bacterial flagellin N-terminal helical region
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
21 NR3C1protein found in more fusions70.6004.722GCR (PF02155, IPR001409): Glucocorticoid receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
22 NR4A2oncoprotein21.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
23 NRIP1oncoprotein90.38913.833ALMT (PF11744, IPR020966): Aluminium activated malate transporter
NRIP1_repr_1 (PF15687, IPR031405): Nuclear receptor-interacting protein 1 repression 1
NRIP1_repr_2 (PF15688, IPR031406): Nuclear receptor-interacting protein 1 repression 2
NRIP1_repr_3 (PF15689, IPR031407): Nuclear receptor-interacting protein 1 repression 3
NRIP1_repr_4 (PF15690, IPR031408): Nuclear receptor-interacting protein 1 repression 4
24 POLR3Finteractor100RNA_pol_Rpc34 (PF05158, IPR007832): RNA polymerase Rpc34 subunit
25 PPARAsuppressor50.6003.222zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
26 PPARDoncoprotein31.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
27 PPARGsuppressor70.6004.722zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
28 PTMSinteractor21.0000Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34
29 RARAoncoprotein50.8330.222zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
30 RARBsuppressor21.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
31 RARGoncoprotein21.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
32 SPOPsuppressor200BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
MATH (PF00917, IPR002083, SM00061): MATH domain
33 THRBsuppressor40.6670.222zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
34 TXLNAprotein found in more fusions200Taxilin (PF09728, IPR026183): Myosin-like coiled-coil protein
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
35 VDRsuppressor60.8000.722zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
36 WRAP53oncoprotein100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
37 ZDHHC12interactor100ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
SH (PF01445, IPR001477): Viral small hydrophobic protein
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase

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