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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RTN1, RALGPS2 (from a repository: Wed Jul 17 11:35:39 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins3 (23.08 %)
The number (and %) of the tumor suppressors2 (15.38 %)
Total number of binary PPIs (saturation %)24 (30.77 %)
The number (and %) of affected PPIs11 (45.83 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI2.923
Assortativity coefficient-0.7346
The network average Clustering coefficient0.469
The number (and %) of a zero Clustering coefficients4 (30.77 %)
The number (and %) of a zero Betweenness Centrality6 (46.15 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RALGPS2,RTN1 All fusions
Proteins found in more fusions SFN (see 1 fusions); YWHAG (see 1 fusions); BCL2L1 (see 1 fusions); YWHAZ (see 5 fusions); RTN4 (see 11 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RALGPS2parental protein40.8336.000PH (PF00169, IPR001849, SM00233): PH domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
2 RTN1parental protein70.09582.000Reticulon (PF02453, IPR003388): Reticulon
3 BCL2L1oncoprotein31.0000Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
4 FAM160A2interactor100RAI16-like (PF10257, IPR019384): Retinoic acid induced 16-like protein
5 HDAC8interactor100DNase-RNase (PF02577, IPR003729): Bifunctional nuclease
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
6 PLEKHF2interactor30.33370.000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
PH (PF00169, IPR001849, SM00233): PH domain
7 RTN4suppressor40.6676.000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Reticulon (PF02453, IPR003388): Reticulon
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
8 SDCBPinteractor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
9 SFNsuppressor50.50064.00014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
10 UGCGinteractor100Glyco_transf_21 (PF13506, IPR025993): Glycosyl transferase family 21
11 YWHABinteractor31.000014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
12 YWHAGprotein found in more fusions50.8336.00014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
13 YWHAZprotein found in more fusions50.8336.00014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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