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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RPS6KA3, C12orf57 (from a repository: Wed Aug 21 12:07:59 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)54
The number (and %) of the onco-proteins22 (40.74 %)
The number (and %) of the tumor suppressors9 (16.67 %)
Total number of binary PPIs (saturation %)169 (11.81 %)
The number (and %) of affected PPIs52 (30.77 %)
The number of possible different fusions14
PPI diameter5
PPI radius3
The average degree of PPI5.481
Assortativity coefficient-0.1664
The network average Clustering coefficient0.464
The number (and %) of a zero Clustering coefficients13 (24.07 %)
The number (and %) of a zero Betweenness Centrality17 (31.48 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: C12orf57,RPS6KA3 All fusions
Proteins found in more fusions CREBBP (see 6 fusions); FGFR1 (see 2 fusions); SLC9A3R1 (see 2 fusions); CDC37 (see 2 fusions); TGM2 (see 3 fusions); COL1A1 (see 14 fusions); HSP90AA1 (see 6 fusions); PLXNB2/TACC1 (see 2 fusions); MAPK1 (see 2 fusions); MAPK14 (see 1 fusions); EGFR (see 2 fusions); NEDD4 (see 1 fusions); MAPT (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 C12orf57parental protein100.022351.633P_C10 (PF14974, IPR026317): Protein C10
2 RPS6KA3parental protein420.1001649.431Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
3 ACO1interactor2043.257Aconitase (PF00330, IPR001030): Aconitase family (aconitate hydratase)
Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
4 ATP5Jinteractor30.33392.981ATP-synt_F6 (PF05511, IPR008387): Mitochondrial ATP synthase coupling factor 6
5 BARX1interactor100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
6 CDC37protein found in more fusions80.66711.333CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
7 COL1A1oncoprotein200COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
EKLF_TAD1 (PF16832, IPR031786): Erythroid krueppel-like transcription factor, transactivation 1
8 CREBBPsuppressor80.52410.927Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
9 CSE1Loncoprotein80.60711.100CAS_CSE1 (PF03378, IPR005043): CAS/CSE protein, C-terminus
Cse1 (PF08506, IPR013713): Cse1
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
10 DFFAsuppressor21.0000CIDE-N (PF02017, IPR003508): CIDE-N domain
DFF-C (PF09033, IPR015121): DNA Fragmentation factor 45kDa, C terminal domain
T2SSppdC (PF12528, IPR022204): Type II secretion prepilin peptidase dependent protein C
SAPIS-gp6 (PF16722, IPR031999): Pathogenicity island protein gp6 in Staphylococcus
11 EGFRoncoprotein150.33064.967Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
12 EIF3Concoprotein21.0000eIF-3c_N (PF05470, IPR008905): Eukaryotic translation initiation factor 3 subunit 8 N-terminus
PCI (PF01399, IPR000717, SM00088): PCI domain
13 ESR1suppressor110.44474.512Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
14 FGFR1oncoprotein50.5001.900I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
15 FKBP7interactor2026.048FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
16 GBAinteractor50.6008.133Glyco_hydro_30 (PF02055, IPR001139): Glycosyl hydrolase family 30 TIM-barrel domain
Glyco_hydro_30C (PF17189): Glycosyl hydrolase family 30 beta sandwich domain
17 GDAinteractor41.0000Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
18 H2AFXsuppressor60.5337.994Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
19 HIST1H3Ainteractor40.6670.667Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
20 HMGN1interactor200HMG14_17 (PF01101, IPR000079, SM00527): HMG14 and HMG17
21 HNRNPH1oncoprotein31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
22 HSP90AA1oncoprotein120.49126.200HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
23 HSPA8oncoprotein110.41884.015HSP70 (PF00012, IPR013126): Hsp70 protein
24 KIAA1456interactor100Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain
Methyltransf_23 (PF13489): Methyltransferase domain
25 LETM1interactor2043.257DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
LETM1 (PF07766, IPR011685): LETM1-like protein
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Acetyltransf_11 (PF13720, IPR029098): Udp N-acetylglucosamine O-acyltransferase; Domain 2
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
26 MAPK1oncoprotein100.52830.074Pkinase (PF00069, IPR000719): Protein kinase domain
27 MAPK14oncoprotein60.5003.833Pkinase (PF00069, IPR000719): Protein kinase domain
28 MAPK3oncoprotein70.6673.167Pkinase (PF00069, IPR000719): Protein kinase domain
29 MAPTprotein found in more fusions50.6670.667Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
30 MASP1interactor30.6670.500CUB (PF00431, IPR000859, SM00042): CUB domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Trypsin (PF00089, IPR001254, SM00020): Trypsin
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
31 NAPRTinteractor30.6672.300NAPRTase (PF04095, IPR007229): Nicotinate phosphoribosyltransferase (NAPRTase) family
32 NEDD4suppressor60.6006.350Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
33 NFATC1oncoprotein100RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
34 NFKBIAoncoprotein30.6670.500Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
35 NPEPPSinteractor60.7335.033Peptidase_M1 (PF01433, IPR014782): Peptidase family M1
ERAP1_C (PF11838, IPR024571): ERAP1-like C-terminal domain
36 NTRK1oncoprotein230.186577.280I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
37 PALM2interactor2027.381Paralemmin (PF03285, IPR004965): Paralemmin
Phage_int_SAM_5 (PF13102, IPR025269): Phage integrase SAM-like domain
AKAP2_C (PF15304, IPR029304): A-kinase anchor protein 2 C-terminus
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
38 PDPK1interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
PH_3 (PF14593): PH domain
39 PEA15suppressor40.6672.000DED (PF01335, IPR001875, SM00031): Death effector domain
40 PLXNB2protein found in more fusions30.33352.324Anth_Ig (PF05587, IPR008400): Anthrax receptor extracellular domain
OPA3 (PF07047, IPR010754): Optic atrophy 3 protein (OPA3)
Plexin_cytopl (PF08337, IPR013548): Plexin cytoplasmic RasGAP domain
PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
TIG (PF01833, IPR002909): IPT/TIG domain
41 PPP1CAsuppressor40.333146.967Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
42 RASAL1suppressor21.0000BTK (PF00779, IPR001562, SM00107): BTK motif
C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
43 RPS6KA1oncoprotein120.37946.807Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
44 SLC9A3R1suppressor100.417207.462EBP50_C (PF09007, IPR015098): EBP50, C-terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
45 SMSinteractor50.9002.233Spermine_synth (PF01564, IPR001045): Spermine/spermidine synthase
46 SNAP23interactor200DivIC (PF04977, IPR007060): Septum formation initiator
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SNAP-25 (PF00835, IPR000928): SNAP-25 family
DUF5089 (PF17002, IPR031547): Domain of unknown function (DUF5089)
47 SRIoncoprotein200EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
48 STIP1interactor51.0000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
Wtap (PF17098, IPR029732): WTAP/Mum2p family
49 TACC1oncoprotein30.33329.115TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC)
DUF4613 (PF15390, IPR028041): Domain of unknown function (DUF4613)
50 TGM2protein found in more fusions60.7002.733Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
51 TMEM139interactor100TMEM51 (PF15345, IPR029265): Transmembrane protein 51
52 TRAF2interactor31.0000MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
53 YBX1oncoprotein50.9000.917CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
54 ZMYM5interactor100DUF2116 (PF09889, IPR019216): Uncharacterized protein containing a Zn-ribbon (DUF2116)
zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain

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