Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins RPS6, PARD6G (from a repository: Sun Dec 2 00:39:08 2018)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 212 The number (and %) of the onco-proteins 53 (25.00 %) The number (and %) of the tumor suppressors 21 (9.91 %) Total number of binary PPIs (saturation %) 6757 (30.21 %) The number (and %) of affected PPIs 210 (3.11 %) The number of possible different fusions 41 PPI diameter 5 PPI radius 3 The average degree of PPI 63.226 Assortativity coefficient -0.0138 The network average Clustering coefficient 0.617 The number (and %) of a zero Clustering coefficients 2 (0.94 %) The number (and %) of a zero Betweenness Centrality 3 (1.42 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: RPS6,PARD6G	All fusions
Proteins found in more fusions	VHL (see 1 fusions); YWHAH (see 2 fusions); HNRNPU/RPL24 (see 1 fusions); RPLP2 (see 1 fusions); RPS24/RPS23 (see 1 fusions); RPS24/RPS27 (see 1 fusions); EEF1A1/RPL12 (see 1 fusions); RPL38/RPL3 (see 1 fusions); NCL (see 3 fusions); RPS19/RPS14 (see 1 fusions); TUBG1 (see 1 fusions); NTRK1/RPL7A (see 1 fusions); CUL3 (see 1 fusions); RAC1 (see 1 fusions); NAP1L1 (see 4 fusions); KIF11 (see 1 fusions); COPS5 (see 1 fusions); TP53 (see 3 fusions); CRY2 (see 3 fusions); RACK1 (see 3 fusions); FN1/RPL6 (see 1 fusions); CUL1 (see 3 fusions); GAN (see 1 fusions); RPL30/NOP58 (see 1 fusions); VCP (see 4 fusions); HSP90AA1 (see 5 fusions); HSP90AB1 (see 3 fusions); MARK2 (see 2 fusions); RPS6/RPL27 (see 1 fusions); IMPDH2 (see 2 fusions); CLINT1 (see 2 fusions); STAU1 (see 2 fusions); CUL7 (see 2 fusions); RACK1/FN1 (see 1 fusions); MTOR (see 1 fusions); NCL/NAP1L1 (see 1 fusions); SFN (see 1 fusions); PABPC1 (see 2 fusions); SERBP1 (see 1 fusions); RPTOR (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	RPS6	parental protein	193	0.343	5055.709	Ribosomal_S6e (PF01092, IPR001377): Ribosomal protein S6e DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574)
2	PARD6G	parental protein	17	0.213	563.502	PB1 (PF00564, IPR000270, SM00666): PB1 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
3	ARRB2	interactor	59	0.550	148.694	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
4	ATF4	oncoprotein	4	0.667	0.511	bZIP_1 (PF00170, IPR004827): bZIP transcription factor
5	BRINP1	suppressor	5	0.300	18.793	MACPF (PF01823, IPR020864, SM00457): MAC/Perforin domain
6	CAND1	interactor	118	0.573	297.029	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
7	CBX8	interactor	22	0.590	58.702	Atrophin-1 (PF03154, IPR002951): Atrophin-1 family Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain RBR (PF17208): RNA binding Region CBX7_C (PF17218): CBX family C-terminal motif
8	CD81	interactor	48	0.723	26.056	Tetraspannin (PF00335, IPR018499): Tetraspanin family
9	CDC42	oncoprotein	8	0.333	48.385	Ras (PF00071, IPR001806, SM00173): Ras family
10	CEP250	interactor	60	0.769	43.652	ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1 DivIC (PF04977, IPR007060): Septum formation initiator DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) EHN (PF06441, IPR010497): Epoxide hydrolase N terminus ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family IncA (PF04156, IPR007285): IncA protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain SlyX (PF04102, IPR007236): SlyX Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal TSC22 (PF01166, IPR000580): TSC-22/dip/bun family CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570) DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
11	CLINT1	protein found in more fusions	9	0.571	0.600	ENTH (PF01417, IPR001026, SM00273): ENTH domain
12	COPS5	protein found in more fusions	105	0.615	182.898	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
13	CRY2	protein found in more fusions	19	0.542	4.914	DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
14	CUL1	suppressor	109	0.577	252.721	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
15	CUL2	suppressor	74	0.682	111.428	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
16	CUL3	protein found in more fusions	117	0.534	543.029	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
17	CUL4B	oncoprotein	62	0.654	86.578	Cullin (PF00888, IPR001373, SM00182): Cullin family EBP50_C (PF09007, IPR015098): EBP50, C-terminal Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain MDFI (PF15316, IPR026134): MyoD family inhibitor
18	CUL5	suppressor	75	0.667	86.959	Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
19	CUL7	protein found in more fusions	79	0.546	174.909	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
20	DCC	suppressor	12	0.803	1.601	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Neogenin_C (PF06583, IPR010560): Neogenin C-terminus DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
21	DCUN1D1	interactor	34	0.749	10.275	Cullin_binding (PF03556, IPR005176): Cullin binding UBA_4 (PF14555): UBA-like domain
22	DDX18	interactor	37	0.688	14.284	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3 Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF4217 (PF13959, IPR025313, SM01178): Domain of unknown function (DUF4217)
23	DHX9	oncoprotein	51	0.511	62.738	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold T2SSE (PF00437, IPR001482): Type II/IV secretion system protein HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
24	EBNA1BP2	interactor	35	0.739	10.237	Ebp2 (PF05890, IPR008610): Eukaryotic rRNA processing protein EBP2
25	EEF1A1	suppressor	84	0.564	251.941	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
26	EEF2	interactor	57	0.630	52.579	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
27	EIF2A	interactor	16	0.600	18.099	Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
28	EIF3B	interactor	25	0.187	70.965	eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal PALB2_WD40 (PF16756, IPR031920): Partner and localizer of BRCA2 WD40 domain Methyltr_RsmF_N (PF17125, IPR031341): N-terminal domain of 16S rRNA methyltransferase RsmF
29	EIF3CL	interactor	22	0.766	5.544	eIF-3c_N (PF05470, IPR008905): Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI (PF01399, IPR000717, SM00088): PCI domain
30	EIF4A3	interactor	53	0.650	37.682	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
31	EIF5	interactor	8	0.643	4.233	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5 W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
32	EIF5B	interactor	11	0.600	1.190	GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 MIase (PF02426, IPR026029): Muconolactone delta-isomerase NOA36 (PF06524, IPR010531): NOA36 protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306) IF-2 (PF11987, IPR023115): Translation-initiation factor 2 DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807) GTP_EFTU_D4 (PF14578, IPR029459): Elongation factor Tu domain 4 DUF4632 (PF15451, IPR027952): Domain of unknown function (DUF4632) Coilin_N (PF15862, IPR031722): Coilin N-terminus DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
33	EIF6	interactor	40	0.687	24.306	eIF-6 (PF01912, IPR002769, SM00654): eIF-6 family
34	ESR1	suppressor	88	0.554	336.091	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
35	FAU	interactor	45	0.785	14.669	Ribosomal_S30 (PF04758, IPR006846): Ribosomal protein S30 ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
36	FBL	interactor	61	0.627	84.484	Fibrillarin (PF01269, IPR000692): Fibrillarin
37	FBXO6	interactor	44	0.483	61.268	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
38	FN1	oncoprotein	103	0.552	435.284	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
39	FRS2	interactor	3	0.333	2.783	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
40	GAN	protein found in more fusions	32	0.615	19.343	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif
41	GNL3	interactor	46	0.750	17.115	GN3L_Grn1 (PF08701, IPR014813): GNL3L/Grn1 putative GTPase GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family FAM176 (PF14851): FAM176 family
42	HDAC6	oncoprotein	9	0.643	5.361	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP) zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
43	HIST1H2AD	interactor	16	0.817	1.108	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
44	HNRNPA0	interactor	30	0.607	9.478	SAP130_C (PF16014, IPR031963): Histone deacetylase complex subunit SAP130 C-terminus
45	HNRNPA1	interactor	69	0.399	477.992	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
46	HNRNPM	interactor	77	0.581	103.215	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region
47	HNRNPU	protein found in more fusions	126	0.519	400.719	CDC45 (PF02724, IPR003874): CDC45-like protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
48	HSP90AA1	oncoprotein	63	0.447	294.987	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
49	HSP90AB1	oncoprotein	59	0.458	145.667	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
50	HSPA4	interactor	29	0.360	261.356	Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
51	ICAM1	oncoprotein	53	0.779	25.533	Adhes-Ig_like (PF09085, IPR015169): Adhesion molecule, immunoglobulin-like C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
52	IGSF8	oncoprotein	56	0.752	30.906	V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
53	ILF2	interactor	71	0.639	76.544	DZF (PF07528, IPR006561, SM00572): DZF domain
54	ILF3	oncoprotein	85	0.650	109.726	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif DZF (PF07528, IPR006561, SM00572): DZF domain
55	IMPDH2	protein found in more fusions	17	0.358	13.021	IMPDH (PF00478, IPR001093): IMP dehydrogenase / GMP reductase domain
56	ITGA4	interactor	79	0.641	133.793	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
57	KIF11	protein found in more fusions	16	0.467	65.373	Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2 DUF106 (PF01956, IPR002809): Integral membrane protein DUF106 DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein KxDL (PF10241, IPR019371): Uncharacterized conserved protein Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510) Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding
58	LLGL1	suppressor	9	0.444	42.917	Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal LLGL (PF08366, IPR013577): LLGL2 WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
59	LLGL2	interactor	8	0.286	29.617	Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal LLGL (PF08366, IPR013577): LLGL2 WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain RAB3GAP2_N (PF14655, IPR032839): Rab3 GTPase-activating protein regulatory subunit N-terminus
60	LOC101929876	interactor	62	0.939	5.197	NA
61	MAGOH	interactor	38	0.670	35.963	Mago_nashi (PF02792, IPR004023): Mago nashi protein
62	MAPKAP1	interactor	7	0.667	2.424	SIN1 (PF05422, IPR008828): Stress-activated map kinase interacting protein 1 (SIN1) CRIM (PF16978, IPR031567): SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH (PF16979, IPR031313): SAPK-interacting protein 1 (Sin1), Pleckstrin-homology
63	MARK2	protein found in more fusions	10	0.556	24.876	DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702) KA1 (PF02149, IPR001772): Kinase associated domain 1 Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
64	MDM2	oncoprotein	49	0.441	246.965	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
65	MTOR	oncoprotein	18	0.419	81.680	DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats TPR_19 (PF14559): Tetratricopeptide repeat
66	MYBBP1A	suppressor	42	0.722	16.289	DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi Pol_alpha_B_N (PF08418, IPR013627): DNA polymerase alpha subunit B N-terminal
67	NAP1L1	protein found in more fusions	34	0.723	15.159	NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP) RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31 PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
68	NCL	protein found in more fusions	76	0.508	259.238	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Myc_N (PF01056, IPR012682): Myc amino-terminal region RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YL1 (PF05764, IPR008895): YL1 nuclear protein Limkain-b1 (PF11608, IPR024582): Limkain b1
69	NDRG1	suppressor	22	0.645	7.398	Ndr (PF03096, IPR004142): Ndr family
70	NFIA	interactor	11	0.691	1.209	CTF_NFI (PF00859, IPR000647): CTF/NF-I family transcription modulation region NfI_DNAbd_pre-N (PF10524, IPR019548): Nuclear factor I protein pre-N-terminus MH1 (PF03165, IPR003619, SM00523): MH1 domain
71	NIFK	interactor	42	0.674	42.073	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) hNIFK_binding (PF12196, IPR021043): FHA Ki67 binding domain of hNIFK
72	NOLC1	interactor	27	0.652	128.958	DTHCT (PF08070, IPR012542): DTHCT (NUC029) region SRP40_C (PF05022, IPR007718): SRP40, C-terminal domain Stm1_N (PF09598, IPR019084): Stm1 stn_TNFRSF12A (PF12191, IPR022316): Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain NST1 (PF13945, IPR025279): Salt tolerance down-regulator SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611) PAF (PF15715, IPR031444): PCNA-associated factor IMUP (PF15761, IPR026621): Immortalisation up-regulated protein NuDC (PF16273, IPR032572): Nuclear distribution C domain PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
73	NOP2	interactor	51	0.705	40.460	BSP_II (PF05432, IPR008412): Bone sialoprotein II (BSP-II) Methyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F P120R (PF08062, IPR012586): P120R (NUC006) repeat Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein DUF2477 (PF10631, IPR018904): Protein of unknown function (DUF2477) FAM176 (PF14851): FAM176 family Methyltr_RsmF_N (PF17125, IPR031341): N-terminal domain of 16S rRNA methyltransferase RsmF
74	NOP56	interactor	87	0.649	428.016	Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5 SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
75	NOP58	protein found in more fusions	42	0.729	16.537	Cellulose_synt (PF03552, IPR005150): Cellulose synthase Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
76	NOP9	interactor	6	0.667	0.816	PUF (PF00806, IPR001313, SM00025): Pumilio-family RNA binding repeat
77	NPM1	suppressor	130	0.485	1172.731	Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
78	NTRK1	oncoprotein	95	0.376	1024.349	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
79	OBSL1	interactor	58	0.548	80.229	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
80	PABPC1	oncoprotein	73	0.577	116.830	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain YflT (PF11181, IPR025889): Heat induced stress protein YflT
81	PAN2	interactor	84	0.676	140.452	RNase_T (PF00929, IPR013520): Exonuclease UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase WD40_like (PF17005, IPR031544): WD40-like domain
82	PARD3	interactor	13	0.385	77.850	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
83	PARD6B	interactor	12	0.364	63.765	PB1 (PF00564, IPR000270, SM00666): PB1 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
84	PARK2	suppressor	44	0.471	140.337	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
85	PCK1	interactor	10	0.933	0.108	PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
86	PLA2G12A	interactor	2	1.000	0	PLA2G12 (PF06951, IPR010711): Group XII secretory phospholipase A2 precursor (PLA2G12)
87	PNMA2	interactor	4	0.167	22.741	PNMA (PF14893, IPR026523): PNMA
88	PNMA3	interactor	3	0	16.049	zf-CCHC (PF00098, IPR001878): Zinc knuckle PNMA (PF14893, IPR026523): PNMA
89	PNMAL1	interactor	1	0	0	PNMA (PF14893, IPR026523): PNMA
90	PNO1	interactor	26	0.732	9.591	KH_1 (PF00013, IPR004088, SM00322): KH domain
91	POT1	interactor	13	0.470	8.529	POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13 tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
92	PRKACB	interactor	6	0.733	0.227	Pkinase (PF00069, IPR000719): Protein kinase domain
93	PRKCI	interactor	14	0.407	78.832	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
94	PRKCSH	interactor	5	0.400	0.324	CDC45 (PF02724, IPR003874): CDC45-like protein Ax_dynein_light (PF10211, IPR019347): Axonemal dynein light chain PRKCSH-like (PF12999, IPR028146): Glucosidase II beta subunit-like PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein EF-hand_5 (PF13202, IPR002048): EF hand
95	PRKCZ	interactor	14	0.410	84.432	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
96	PTEN	suppressor	35	0.714	171.945	DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
97	PTOV1	interactor	6	0.400	5.252	Med25 (PF11232, IPR021394): Mediator complex subunit 25 PTOV activation and synapsin 2
98	PYM1	interactor	33	0.797	13.637	CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD) Mago-bind (PF09282, IPR015362): Mago binding AAA_23 (PF13476): AAA domain
99	RAC1	oncoprotein	10	0.306	63.319	Ras (PF00071, IPR001806, SM00173): Ras family
100	RACK1	suppressor	59	0.636	438.505	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
101	RAD21	oncoprotein	39	0.727	16.674	Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein FAM176 (PF14851): FAM176 family WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
102	RICTOR	interactor	15	0.543	17.241	RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_N (PF14664, IPR028267): Rapamycin-insensitive companion of mTOR, N-term RICTOR_phospho (PF14665, IPR029259): Rapamycin-insensitive companion of mTOR, phosphorylation-site RICTOR_M (PF14666, IPR029451): Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V (PF14668, IPR029452): Rapamycin-insensitive companion of mTOR, domain 5
103	RPL10	suppressor	114	0.628	203.640	Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
104	RPL10A	interactor	109	0.689	126.616	Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
105	RPL10L	interactor	67	0.886	21.178	Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e Cytochrome_P460 (PF16694, IPR032033): Cytochrome P460
106	RPL11	suppressor	122	0.616	213.552	Ribosomal_L5 (PF00281, IPR002132): Ribosomal protein L5 Ribosomal_L5_C (PF00673, IPR002132): ribosomal L5P family C-terminus
107	RPL12	protein found in more fusions	108	0.693	107.881	Ribosomal_L11 (PF00298, IPR020783): Ribosomal protein L11, RNA binding domain Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain
108	RPL13	interactor	114	0.614	295.409	Ribosomal_L13e (PF01294, IPR001380): Ribosomal protein L13e
109	RPL13A	interactor	88	0.782	49.283	Ribosomal_L13 (PF00572, IPR005822): Ribosomal protein L13
110	RPL14	interactor	121	0.620	208.954	KOW (PF00467, IPR005824, SM00739): KOW motif Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14 UPF0688 (PF15772, IPR031530): UPF0688 family
111	RPL15	interactor	116	0.644	214.242	Ribosomal_L15e (PF00827, IPR000439): Ribosomal L15
112	RPL17	interactor	99	0.681	99.748	Ribosomal_L22 (PF00237, IPR001063): Ribosomal protein L22p/L17e
113	RPL18	interactor	121	0.637	174.340	Ribosomal_L18 (PF17135): Ribosomal protein 60S L18 and 50S L18e
114	RPL18A	interactor	102	0.691	119.306	Ribosomal_L18A (PF01775, IPR023573): Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A
115	RPL19	interactor	117	0.638	173.719	DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682) Ribosomal_L19e (PF01280, IPR000196): Ribosomal protein L19e
116	RPL21	interactor	112	0.694	107.106	Ribosomal_L21e (PF01157, IPR001147): Ribosomal protein L21e
117	RPL22	oncoprotein	100	0.732	159.636	Ribosomal_L22e (PF01776, IPR002671): Ribosomal L22e protein family
118	RPL23	interactor	120	0.589	513.000	Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
119	RPL23A	interactor	125	0.585	367.378	Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23 Ribosomal_L23eN (PF03939, IPR005633): Ribosomal protein L23, N-terminal domain
120	RPL24	protein found in more fusions	109	0.683	123.983	MAS20 (PF02064, IPR002056): MAS20 protein import receptor Ribosomal_L24e (PF01246, IPR000988): Ribosomal protein L24e
121	RPL26	oncoprotein	67	0.682	77.496	TP2 (PF01254, IPR000678): Nuclear transition protein 2 Ribosomal_L26 (PF16906, IPR005756): Ribosomal proteins L26 eukaryotic, L24P archaeal
122	RPL26L1	interactor	54	0.739	22.978	Ribosomal_L26 (PF16906, IPR005756): Ribosomal proteins L26 eukaryotic, L24P archaeal
123	RPL27	protein found in more fusions	95	0.759	65.004	Ribosomal_L27e (PF01777, IPR001141): Ribosomal L27e protein family
124	RPL27A	interactor	98	0.711	152.750	Ribosomal_L27A (PF00828, IPR021131): Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
125	RPL28	interactor	52	0.679	70.125	Ribosomal_L28e (PF01778, IPR029004): Ribosomal L28e protein family
126	RPL29	interactor	42	0.818	26.290	BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain Ribosomal_L29e (PF01779, IPR002673): Ribosomal L29e protein family
127	RPL3	protein found in more fusions	108	0.686	207.631	Ribosomal_L3 (PF00297, IPR000597): Ribosomal protein L3
128	RPL30	protein found in more fusions	96	0.739	71.023	NCBP3 (PF10309, IPR019416): Nuclear cap-binding protein subunit 3
129	RPL31	interactor	106	0.679	116.110	Ribosomal_L31e (PF01198, IPR000054): Ribosomal protein L31e
130	RPL32	interactor	62	0.831	26.650	Ribosomal_L32e (PF01655, IPR001515): Ribosomal protein L32
131	RPL34	interactor	64	0.863	16.425	Redoxin (PF08534, IPR013740): Redoxin Ribosomal_L34e (PF01199, IPR008195): Ribosomal protein L34e
132	RPL35	interactor	89	0.786	48.162	Ribosomal_L29 (PF00831, IPR001854): Ribosomal L29 protein XFP_N (PF09364, IPR018970): XFP N-terminal domain
133	RPL35A	interactor	67	0.886	12.573	Ribosomal_L35Ae (PF01247, IPR001780): Ribosomal protein L35Ae
134	RPL36	interactor	88	0.807	39.456	Ribosomal_L36e (PF01158, IPR000509): Ribosomal protein L36e
135	RPL37A	interactor	102	0.664	181.109	Ribosomal_L37ae (PF01780, IPR002674): Ribosomal L37ae protein family
136	RPL38	protein found in more fusions	82	0.816	47.602	Ribosomal_L38e (PF01781, IPR002675): Ribosomal L38e protein family
137	RPL3L	interactor	34	0.998	0.032	Ribosomal_L3 (PF00297, IPR000597): Ribosomal protein L3
138	RPL4	interactor	132	0.571	338.523	Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family Ribos_L4_asso_C (PF14374, IPR025755): 60S ribosomal protein L4 C-terminal domain
139	RPL5	suppressor	140	0.538	539.924	Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
140	RPL6	protein found in more fusions	136	0.560	331.468	Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e Ribosomal_L6e_N (PF03868, IPR005568): Ribosomal protein L6, N-terminal domain
141	RPL7	interactor	124	0.607	226.726	Ribosomal_L30 (PF00327, IPR016082): Ribosomal protein L30p/L7e Ribosomal_L30_N (PF08079, IPR012988): Ribosomal L30 N-terminal domain
142	RPL7A	protein found in more fusions	115	0.644	156.586	Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
143	RPL8	interactor	116	0.626	198.012	Ribosomal_L2 (PF00181, IPR022666): Ribosomal Proteins L2, RNA binding domain Ribosomal_L2_C (PF03947, IPR022669): Ribosomal Proteins L2, C-terminal domain
144	RPL9	interactor	112	0.665	471.790	Ribosomal_L6 (PF00347, IPR020040): Ribosomal protein L6
145	RPLP0	interactor	119	0.624	283.999	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
146	RPLP0P6	interactor	74	0.748	69.508	NA
147	RPLP1	interactor	75	0.857	17.743	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
148	RPLP2	protein found in more fusions	94	0.746	62.781	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
149	RPS10	interactor	99	0.704	125.167	S10_plectin (PF03501, IPR005326): Plectin/S10 domain