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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PTPN21, RPN2 (from a repository: Wed Jul 24 13:46:41 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)74
The number (and %) of the onco-proteins19 (25.68 %)
The number (and %) of the tumor suppressors13 (17.57 %)
Total number of binary PPIs (saturation %)454 (16.81 %)
The number (and %) of affected PPIs72 (15.86 %)
The number of possible different fusions10
PPI diameter5
PPI radius3
The average degree of PPI11.784
Assortativity coefficient-0.1550
The network average Clustering coefficient0.499
The number (and %) of a zero Clustering coefficients4 (5.41 %)
The number (and %) of a zero Betweenness Centrality11 (14.86 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RPN2,PTPN21 All fusions
Proteins found in more fusions VCP (see 4 fusions); TCF3 (see 4 fusions); MCM2 (see 1 fusions); HDAC5 (see 1 fusions); EZH2 (see 1 fusions); CUL3 (see 1 fusions); ATP5A1 (see 1 fusions); FAF1 (see 3 fusions); MYC (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RPN2parental protein680.1572229.885Ribophorin_II (PF05817, IPR008814): Oligosaccharyltransferase subunit Ribophorin II
2 PTPN21parental protein40.167286.000FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PRIMA1 (PF16101): Proline-rich membrane anchor 1
3 ADRB2interactor140.449105.9327tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4 ARRB2interactor100.37863.011Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
5 ATP5A1protein found in more fusions140.50019.356ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
6 AUP1interactor100.5338.866CUE (PF02845, IPR003892, SM00546): CUE domain
7 BMXinteractor30.33333.643BTK (PF00779, IPR001562, SM00107): BTK motif
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PH_8 (PF15409): Pleckstrin homology domain
8 BREoncoprotein21.0000BRE (PF06113, IPR010358): Brain and reproductive organ-expressed protein (BRE)
9 CANXinteractor290.323147.219Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
10 CLGNinteractor120.53013.794Calreticulin (PF00262, IPR001580): Calreticulin family
CDC45 (PF02724, IPR003874): CDC45-like protein
S-antigen (PF05756, IPR008825): S-antigen protein
DUF3742 (PF12553, IPR022213): Protein of unknown function (DUF3742)
SieB (PF14163, IPR025982): Super-infection exclusion protein B
11 CLN3interactor60.8001.000CLN3 (PF02487, IPR003492): CLN3 protein
12 CUL3protein found in more fusions220.37167.394Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
13 DDOSTinteractor240.330115.891DDOST_48kD (PF03345, IPR005013): Oligosaccharyltransferase 48 kDa subunit beta
14 DDX39Binteractor90.6395.709DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
15 DERL2interactor30.6670.200DER1 (PF04511, IPR007599): Der1-like family
16 EEDsuppressor120.43614.949WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
17 EPRSinteractor120.40915.917GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
ProRS-C_1 (PF09180, IPR016061, SM00946): Prolyl-tRNA synthetase, C-terminal
tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain
tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
18 ESR1suppressor200.345161.118Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
19 EZH2suppressor90.6433.940CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
20 FAF1protein found in more fusions100.6114.829UBX (PF00789, IPR001012, SM00166): UBX domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
AAA_11 (PF13086): AAA domain
UBA_4 (PF14555): UBA-like domain
21 FBN3interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
TB (PF00683, IPR017878): TB domain
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
22 FBXO25suppressor40.500120.410Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
23 FBXO6interactor190.40438.721FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
24 FUSsuppressor150.48622.538Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
25 GSTK1interactor51.0000DSBA (PF01323, IPR001853): DSBA-like thioredoxin domain
26 H2AFXsuppressor70.3817.262Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
27 HDAC5protein found in more fusions170.48318.823Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
28 HSP90B1suppressor240.38085.447CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
29 ILF3oncoprotein180.34048.881dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
30 IPO5interactor90.5565.934HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
AAA_30 (PF13604): AAA domain
HEAT_2 (PF13646): HEAT repeats
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
31 IPO9interactor110.5279.706IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
HEAT_EZ (PF13513): HEAT-like repeat
32 KDSRoncoprotein100.5787.6407kD_coat (PF02495, IPR003411): 7kD viral coat protein
adh_short (PF00106, IPR002198): short chain dehydrogenase
33 KIF1Cinteractor100FHA (PF00498, IPR000253, SM00240): FHA domain
IncA (PF04156, IPR007285): IncA protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
34 MCM2oncoprotein190.40536.012AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
35 MMS19interactor80.6079.525DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
36 MYConcoprotein90.6074.442HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
37 NCLNinteractor100.5337.651Peptidase_M28 (PF04389, IPR007484): Peptidase family M28
38 NDRG1suppressor60.5331.896Ndr (PF03096, IPR004142): Ndr family
39 NGFRsuppressor40.6670.500LHC (PF00556, IPR000066): Antenna complex alpha/beta subunit
40 NTRK1oncoprotein340.258433.229I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
41 PARD6Binteractor100PB1 (PF00564, IPR000270, SM00666): PB1 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
42 PCinteractor90.6674.391Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
HMGL-like (PF00682, IPR000891): HMGL-like
PYC_OADA (PF02436, IPR003379): Conserved carboxylase domain
43 PDIA3interactor100.46712.537Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
44 PPP2R1Aoncoprotein140.53815.480TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
45 RAB1Aoncoprotein160.40038.424Ras (PF00071, IPR001806, SM00173): Ras family
46 RAB1Boncoprotein110.54510.382Ras (PF00071, IPR001806, SM00173): Ras family
47 RAB7Asuppressor130.33325.770Ras (PF00071, IPR001806, SM00173): Ras family
48 RBBP4oncoprotein130.46219.487eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
49 RCHY1suppressor200C1_2 (PF03107, IPR004146): C1 domain
zf-CHY (PF05495, IPR008913): CHY zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zinc_ribbon_6 (PF14599): Zinc-ribbon
50 RCN1interactor110.49110.041EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
51 RDH13interactor60.8001.019adh_short (PF00106, IPR002198): short chain dehydrogenase
52 RHOAsuppressor21.0000Ras (PF00071, IPR001806, SM00173): Ras family
53 RNF185interactor50.8330.333zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
54 RPLP0interactor110.40012.053Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
55 RPN1oncoprotein380.279326.573Ribophorin_I (PF04597, IPR007676): Ribophorin I
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
56 SAP18interactor30.6670.167SAP18 (PF06487, IPR010516): Sin3 associated polypeptide p18 (SAP18)
57 SIRT7interactor110.40013.058DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
58 SPTAN1oncoprotein90.6115.112EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Tetrabrachion (PF11401, IPR021535): Tetrabrachion
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
59 SRConcoprotein70.133424.769Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
60 SSR4interactor170.39036.076TRAP-delta (PF05404, IPR008855): Translocon-associated protein, delta subunit precursor (TRAP-delta)
OppC_N (PF12911, IPR025966): N-terminal TM domain of oligopeptide transport permease C
61 STT3Binteractor110.6009.188STT3 (PF02516, IPR003674): Oligosaccharyl transferase STT3 subunit
62 TCF3suppressor41.0000CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
63 TCTN1interactor90.5565.445DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
64 TCTN2interactor130.52611.508DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
65 TCTN3interactor170.36052.264DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
66 TM9SF2interactor21.0000FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
EMP70 (PF02990, IPR004240): Endomembrane protein 70
67 TM9SF4interactor21.0000EMP70 (PF02990, IPR004240): Endomembrane protein 70
DUF4229 (PF14012, IPR025323): Protein of unknown function (DUF4229)
68 TMBIM4interactor21.0000Presenilin (PF01080, IPR001108): Presenilin
Bax1-I (PF01027, IPR006214): Inhibitor of apoptosis-promoting Bax1
69 UBAC2interactor30.6670.286Rhomboid (PF01694, IPR022764): Rhomboid family
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
70 UBL4Ainteractor160.32538.033ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
71 UQCRC2oncoprotein220.38572.525Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
72 VAPAinteractor150.37138.448DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
73 VAPBinteractor100.6005.476ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
ZapB (PF06005, IPR009252): Cell division protein ZapB
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
74 VCPprotein found in more fusions310.283189.886AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)

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