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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RPL29, PTPN21 (from a repository: Sat Aug 17 07:06:34 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)67
The number (and %) of the onco-proteins15 (22.39 %)
The number (and %) of the tumor suppressors7 (10.45 %)
Total number of binary PPIs (saturation %)893 (40.39 %)
The number (and %) of affected PPIs65 (7.28 %)
The number of possible different fusions12
PPI diameter4
PPI radius2
The average degree of PPI26.119
Assortativity coefficient-0.0512
The network average Clustering coefficient0.714
The number (and %) of a zero Clustering coefficients6 (8.96 %)
The number (and %) of a zero Betweenness Centrality8 (11.94 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RPL29,PTPN21 All fusions
Proteins found in more fusions STAU1 (see 2 fusions); RPS24/RPS23 (see 1 fusions); HSP90AA1 (see 6 fusions); NTRK1/RPL7A (see 1 fusions); NPM1 (see 1 fusions); CUL7 (see 2 fusions); RPL5 (see 1 fusions); EWSR1 (see 1 fusions); CHD3 (see 1 fusions); FN1/RPL6 (see 1 fusions); PSMC5 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RPL29parental protein610.4381078.328BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Ribosomal_L29e (PF01779, IPR002673): Ribosomal L29e protein family
2 PTPN21parental protein40.16710.441FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PRIMA1 (PF16101): Proline-rich membrane anchor 1
3 BLMHinteractor200Peptidase_C1_2 (PF03051, IPR004134): Peptidase C1-like family
4 BMXinteractor30.66710.667BTK (PF00779, IPR001562, SM00107): BTK motif
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PH_8 (PF15409): Pleckstrin homology domain
5 BTF3interactor31.0000NAC (PF01849, IPR002715): NAC domain
6 CHD3oncoprotein41.0000CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087)
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956)
FAM176 (PF14851): FAM176 family
7 CUL7protein found in more fusions280.67858.638ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
8 DDX56interactor100.7781.074DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
9 DESinteractor21.0000Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
HAUS-augmin3 (PF14932, IPR032733): HAUS augmin-like complex subunit 3
10 EEDsuppressor170.83310.015WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
11 EIF4Binteractor50.5000.666RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF3774 (PF12609, IPR022251): Wound-induced protein
PROL5-SMR (PF15621, IPR026288): Proline-rich submaxillary gland androgen-regulated family
12 EIF5interactor40.8330.087CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region
eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5
W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
13 ESR1suppressor360.74695.317Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
14 EWSR1oncoprotein150.7142.575RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
15 FBXW7suppressor40.6670.382Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
16 FN1oncoprotein330.85625.441fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
17 HIST1H3Einteractor110.7646.540Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
18 HSP90AA1oncoprotein240.672165.174HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
19 IL7Rinteractor70.9520.056fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
20 ILF3oncoprotein390.76236.978dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
21 KIF1Cinteractor2014.567FHA (PF00498, IPR000253, SM00240): FHA domain
IncA (PF04156, IPR007285): IncA protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
22 MDC1suppressor40.6670.640FHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
23 NOC4Linteractor100CBF (PF03914, IPR005612, SM00521): CBF/Mak21 family
24 NPM1suppressor420.693194.735Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
25 NTRK1oncoprotein290.61696.391I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
26 PAN2interactor320.83139.157RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
27 PARD6Binteractor2023.440PB1 (PF00564, IPR000270, SM00666): PB1 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
28 POU5F1oncoprotein70.6001.091Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
29 PSMC5protein found in more fusions70.6000.532AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
30 PSTPIP1interactor41.0000ABATE (PF07336, IPR010852): Putative stress-induced transcription regulator
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
WXG100 (PF06013, IPR010310): Proteins of 100 residues with WXG
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
31 RNF2interactor280.68438.522zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
32 RPL10suppressor440.749154.714Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
33 RPL10Ainteractor400.8768.553Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
34 RPL12interactor390.85612.900Ribosomal_L11 (PF00298, IPR020783): Ribosomal protein L11, RNA binding domain
Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain
35 RPL14interactor440.77735.063KOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14
UPF0688 (PF15772, IPR031530): UPF0688 family
36 RPL17interactor410.79565.474Ribosomal_L22 (PF00237, IPR001063): Ribosomal protein L22p/L17e
37 RPL21interactor410.83733.587Ribosomal_L21e (PF01157, IPR001147): Ribosomal protein L21e
38 RPL23Ainteractor430.78348.711Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
Ribosomal_L23eN (PF03939, IPR005633): Ribosomal protein L23, N-terminal domain
39 RPL32interactor340.82928.860Ribosomal_L32e (PF01655, IPR001515): Ribosomal protein L32
40 RPL38interactor330.89814.047Ribosomal_L38e (PF01781, IPR002675): Ribosomal L38e protein family
41 RPL4interactor400.87411.151Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family
Ribos_L4_asso_C (PF14374, IPR025755): 60S ribosomal protein L4 C-terminal domain
42 RPL5suppressor420.83822.154Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region
Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
43 RPL6protein found in more fusions420.82325.170Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e
Ribosomal_L6e_N (PF03868, IPR005568): Ribosomal protein L6, N-terminal domain
44 RPL7Aprotein found in more fusions440.78132.218Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
45 RPL8interactor410.79630.893Ribosomal_L2 (PF00181, IPR022666): Ribosomal Proteins L2, RNA binding domain
Ribosomal_L2_C (PF03947, IPR022669): Ribosomal Proteins L2, C-terminal domain
46 RPL9interactor420.83317.755Ribosomal_L6 (PF00347, IPR020040): Ribosomal protein L6
47 RPLP0P6interactor320.9294.647NA
48 RPLP1interactor310.9541.919Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
49 RPS12interactor350.8919.111Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
50 RPS15Ainteractor390.86413.551Ribosomal_S8 (PF00410, IPR000630): Ribosomal protein S8
51 RPS16interactor400.84620.181Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
52 RPS2interactor410.85712.991Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
53 RPS20interactor390.84624.419Ribosomal_S10 (PF00338, IPR027486): Ribosomal protein S10p/S20e
54 RPS23protein found in more fusions380.86621.965Ribosom_S12_S23 (PF00164, IPR006032): Ribosomal protein S12/S23
55 RPS24protein found in more fusions370.8967.472Fascin (PF06268, IPR022768): Fascin domain
Ribosomal_S24e (PF01282, IPR001976): Ribosomal protein S24e
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
56 RPS25interactor390.83525.983Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein
57 RPS26interactor400.83816.450Ribosomal_S26e (PF01283, IPR000892): Ribosomal protein S26e
58 RPS3interactor430.79734.317KH_2 (PF07650, IPR004044): KH domain
Ribosomal_S3_C (PF00189, IPR001351): Ribosomal protein S3, C-terminal domain
59 RPS3Ainteractor430.81026.841Ribosomal_S3Ae (PF01015, IPR001593): Ribosomal S3Ae family
60 RPS4Xinteractor420.82921.160KOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_S4e (PF00900, IPR013845): Ribosomal family S4e
RS4NT (PF08071, IPR013843): RS4NT (NUC023) domain
S4 (PF01479, IPR002942, SM00363): S4 domain
40S_S4_C (PF16121, IPR032277): 40S ribosomal protein S4 C-terminus
61 RPS6interactor420.81842.025Ribosomal_S6e (PF01092, IPR001377): Ribosomal protein S6e
DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574)
62 RPSAinteractor410.80129.242Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
40S_SA_C (PF16122, IPR032281): 40S ribosomal protein SA C-terminus
63 SLC9A3R2interactor100EBP50_C (PF09007, IPR015098): EBP50, C-terminal
GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
64 SRConcoprotein70.40088.805Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
65 STAU1protein found in more fusions250.743159.458dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
66 SYBUinteractor100Herpes_pp85 (PF04637, IPR006731): Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaphilin (PF15290, IPR028197): Golgi-localised syntaxin-1-binding clamp
67 UBL4Ainteractor320.9314.760ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family

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