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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)110
The number (and %) of the onco-proteins21 (19.09 %)
The number (and %) of the tumor suppressors16 (14.55 %)
Total number of binary PPIs (saturation %)1409 (23.50 %)
The number (and %) of affected PPIs109 (7.74 %)
The number of possible different fusions15
PPI diameter4
PPI radius2
The average degree of PPI24.964
Assortativity coefficient0.2898
The network average Clustering coefficient0.605
The number (and %) of a zero Clustering coefficients7 (6.36 %)
The number (and %) of a zero Betweenness Centrality8 (7.27 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: VPS11,RPL28 All fusions
Proteins found in more fusions SMAD4 (see 2 fusions); VPS39 (see 1 fusions); CUL1 (see 3 fusions); KIF11 (see 1 fusions); MARK3 (see 1 fusions); COPS5 (see 1 fusions); UBC (see 1 fusions); RPLP2 (see 1 fusions); TP53 (see 3 fusions); RPL38/RPL3 (see 1 fusions); EZR (see 2 fusions); MCM2 (see 1 fusions); KDM1A (see 2 fusions); RPS19/RPS14 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 VPS11parental protein430.0922163.692DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
VPS11_C (PF12451, IPR024763): Vacuolar protein sorting protein 11 C terminal
TPR_11 (PF13414, IPR011990): TPR repeat
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
2 RPL28parental protein660.497828.513Ribosomal_L28e (PF01778, IPR029004): Ribosomal L28e protein family
3 ARRB2interactor190.74340.303Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
4 BCAR1oncoprotein206.423Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513)
Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
5 BMI1oncoprotein90.35747.369zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
6 BRCA1suppressor150.36342.308BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
7 CAMSAP3interactor2010.065CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
CAMSAP_CKK (PF08683, IPR014797, SM01051): Microtubule-binding calmodulin-regulated spectrin-associated
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
CAMSAP_CC1 (PF17095, IPR031372): Spectrin-binding region of Ca2+-Calmodulin
8 CAND1interactor500.689194.376Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
9 CCDC8interactor240.66445.796Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
10 CCNDBP1suppressor31.0000CheF-arch (PF04283, IPR007381): Chemotaxis signal transduction system protein F from archaea
GCIP (PF13324): Grap2 and cyclin-D-interacting
11 CDK2suppressor400.686189.274Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
12 COPS5protein found in more fusions460.685253.456JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
13 CUL1suppressor450.700153.648Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
14 CUL2suppressor360.74667.582Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
15 DCCsuppressor80.7506.045fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neogenin_C (PF06583, IPR010560): Neogenin C-terminus
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
16 EDNRAinteractor3028.7047tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
17 EIF4A3interactor250.59155.383DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
18 ESR1suppressor340.625228.252Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
19 EZRprotein found in more fusions110.26787.724DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
20 FBXO6interactor150.55221.803FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
21 FN1oncoprotein430.621395.024fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
22 GGA3interactor60.60010.266Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
23 GRSF1interactor70.8100.670RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
VWA_N2 (PF16164, IPR032361): VWA N-terminal
24 GTF2Iinteractor100.37873.919GTF2I (PF02946, IPR004212): GTF2I-like repeat
25 HNRNPUinteractor490.72870.953CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
26 ITGA4interactor350.72269.892FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
27 KDM1Aprotein found in more fusions90.42930.274Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
28 KIAA0368interactor50.50023.013HEAT (PF02985, IPR000357): HEAT repeat
IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
CLASP_N (PF12348, IPR024395): CLASP N terminal
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
Ecm29 (PF13001, IPR024372): Proteasome stabiliser
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
29 KIF11protein found in more fusions90.6794.204Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510)
Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding
30 KRTAP10-3interactor40.6671.596Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
31 KRTAP10-8interactor31.0000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
32 LRSAM1interactor31.0000Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
33 LSM1interactor202.749LSM (PF01423, IPR001163): LSM domain
34 MAGEB2interactor100.9780.056MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
35 MAGOHinteractor190.591157.416Mago_nashi (PF02792, IPR004023): Mago nashi protein
36 MAP2K5oncoprotein300.213PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
37 MARK3protein found in more fusions31.0000KA1 (PF02149, IPR001772): Kinase associated domain 1
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
38 MCM2oncoprotein390.624161.574AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
39 MON1Binteractor51.0000Mon1 (PF03164, IPR004353): Trafficking protein Mon1
40 MOV10interactor220.364266.547AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
41 MSNoncoprotein80.42932.015DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
42 NOTCH1suppressor80.28624.435Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
43 NTRK1oncoprotein440.3011232.435I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
44 NXF1interactor240.221415.135NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
45 PA2G4interactor150.58111.822Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein
TraC (PF07820, IPR012930): TraC-like protein
46 PAN2interactor330.9229.778RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
47 PARVAoncoprotein100CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
48 PCSK9interactor200.213Peptidase_S8 (PF00082, IPR000209): Subtilase family
Inhibitor_I9 (PF05922, IPR010259): Peptidase inhibitor I9
49 RAB7Asuppressor90.417113.959Ras (PF00071, IPR001806, SM00173): Ras family
50 RANBP17oncoprotein30.6670.267CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
51 RDXinteractor60.33320.984ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
52 RILPinteractor60.8001.348NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
53 RNF166interactor21.0000zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zinc-ribbons_6 (PF07191, IPR010807): zinc-ribbons
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
54 RNF181interactor40.3334.320AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
55 RNF2interactor340.485330.086zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
56 RPL13interactor500.73094.275Ribosomal_L13e (PF01294, IPR001380): Ribosomal protein L13e
57 RPL14interactor480.76367.487KOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14
UPF0688 (PF15772, IPR031530): UPF0688 family
58 RPL19interactor480.77454.921DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
Ribosomal_L19e (PF01280, IPR000196): Ribosomal protein L19e
59 RPL21interactor510.71186.509Ribosomal_L21e (PF01157, IPR001147): Ribosomal protein L21e
60 RPL23interactor460.81832.365Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
61 RPL23Ainteractor500.75267.198Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
Ribosomal_L23eN (PF03939, IPR005633): Ribosomal protein L23, N-terminal domain
62 RPL3protein found in more fusions510.73674.431Ribosomal_L3 (PF00297, IPR000597): Ribosomal protein L3
63 RPL34interactor390.76159.503Redoxin (PF08534, IPR013740): Redoxin
Ribosomal_L34e (PF01199, IPR008195): Ribosomal protein L34e
64 RPL35interactor390.9038.145Ribosomal_L29 (PF00831, IPR001854): Ribosomal L29 protein
XFP_N (PF09364, IPR018970): XFP N-terminal domain
65 RPL36interactor440.82629.014Ribosomal_L36e (PF01158, IPR000509): Ribosomal protein L36e
66 RPL38protein found in more fusions400.86220.929Ribosomal_L38e (PF01781, IPR002675): Ribosomal L38e protein family
67 RPL5suppressor500.76367.902Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region
Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
68 RPL7interactor500.74564.908Ribosomal_L30 (PF00327, IPR016082): Ribosomal protein L30p/L7e
Ribosomal_L30_N (PF08079, IPR012988): Ribosomal L30 N-terminal domain
69 RPL8interactor510.72080.022Ribosomal_L2 (PF00181, IPR022666): Ribosomal Proteins L2, RNA binding domain
Ribosomal_L2_C (PF03947, IPR022669): Ribosomal Proteins L2, C-terminal domain
70 RPLP0interactor520.724124.924Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
71 RPLP1interactor390.86234.458Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
72 RPLP2protein found in more fusions450.79436.928Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
73 RPS10interactor470.76066.140S10_plectin (PF03501, IPR005326): Plectin/S10 domain
74 RPS11interactor500.721308.655Ribosomal_S17 (PF00366, IPR000266): Ribosomal protein S17
Ribosomal_S17_N (PF16205, IPR032440): Ribosomal_S17 N-terminal
75 RPS14protein found in more fusions490.78143.382Ribosomal_S11 (PF00411, IPR001971): Ribosomal protein S11
76 RPS15interactor370.9118.537Ribosomal_S19 (PF00203, IPR002222): Ribosomal protein S19
Prok_Ub (PF14454, IPR032866): Prokaryotic Ubiquitin
77 RPS15Ainteractor460.81735.221Ribosomal_S8 (PF00410, IPR000630): Ribosomal protein S8
78 RPS16interactor480.79938.978Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
79 RPS18interactor480.80730.696Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18
80 RPS19protein found in more fusions470.759100.782Ribosomal_S19e (PF01090, IPR001266): Ribosomal protein S19e
81 RPS2interactor520.72984.116Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
82 RPS23interactor460.78683.056Ribosom_S12_S23 (PF00164, IPR006032): Ribosomal protein S12/S23
83 RPS25interactor460.82835.733Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein
84 RPS29interactor190.9710.333Ribosomal_S14 (PF00253, IPR001209): Ribosomal protein S14p/S29e
85 RPS3interactor540.693118.157KH_2 (PF07650, IPR004044): KH domain
Ribosomal_S3_C (PF00189, IPR001351): Ribosomal protein S3, C-terminal domain
86 RPS3Ainteractor530.714104.402Ribosomal_S3Ae (PF01015, IPR001593): Ribosomal S3Ae family
87 RPS6interactor530.669193.581Ribosomal_S6e (PF01092, IPR001377): Ribosomal protein S6e
DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574)
88 SCRIBsuppressor80.25031.970Hormone_3 (PF00159, IPR001955): Pancreatic hormone peptide
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SDA1 (PF05285, IPR007949): SDA1
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
LRR_9 (PF14580): Leucine-rich repeat
AbLIM_anchor (PF16182, IPR032402): Putative adherens-junction anchoring region of AbLIM
89 SHMT2interactor80.39329.951SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
90 SMAD4suppressor70.40066.286MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
91 STX17interactor60.7331.848Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
Gly-zipper_YMGG (PF13441, IPR027367): YMGG-like Gly-zipper
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
92 STX7interactor60.26752.629SNARE (PF05739, IPR000727, SM00397): SNARE domain
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
Syntaxin_2 (PF14523): Syntaxin-like protein
93 TARDBPinteractor380.66590.153RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
94 TDRD3interactor31.0000RMI1_N (PF08585, IPR013894, SM01161): RecQ mediated genome instability protein
TUDOR (PF00567, IPR002999, SM00333): Tudor domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
DUF3472 (PF11958, IPR021862): Domain of unknown function (DUF3472)
95 TGFBRAP1interactor80.60735.742CNH (PF00780, IPR001180, SM00036): CNH domain
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
96 TP53suppressor400.605229.417DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
97 TRIM32suppressor70.26724.891NHL (PF01436, IPR001258): NHL repeat
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
98 TSG101suppressor100.444102.471APG6 (PF04111, IPR007243): Autophagy protein Apg6
Laminin_II (PF06009, IPR010307): Laminin Domain II
UEV (PF05743, IPR008883): UEV domain
Vps23_core (PF09454, IPR017916): Vps23 core domain
99 UBCprotein found in more fusions270.348285.044ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
100 UBE2Uinteractor60.26763.233UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
efb-c (PF12199, IPR021033): Extracellular fibrinogen binding protein C terminal
TMEM154 (PF15102, IPR028064): TMEM154 protein family
101 UBL4Ainteractor350.75871.210ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
102 UVRAGsuppressor70.52419.376C2 (PF00168, IPR000008, SM00239): C2 domain
HTH_1 (PF00126, IPR000847): Bacterial regulatory helix-turn-helix protein, lysR family
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
103 VPS16interactor130.462237.703Vps16_C (PF04840, IPR006925): Vps16, C-terminal region
Vps16_N (PF04841, IPR006926): Vps16, N-terminal region
104 VPS18interactor140.41885.441Pep3_Vps18 (PF05131, IPR007810): Pep3/Vps18/deep orange family
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
105 VPS33Ainteractor90.69435.122Sec1 (PF00995, IPR001619): Sec1 family
106 VPS39protein found in more fusions90.32173.604CNH (PF00780, IPR001180, SM00036): CNH domain
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
107 VPS41interactor100.57816.049Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
108 VPS8interactor50.9004.720GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Vps8 (PF12816, IPR025941): Golgi CORVET complex core vacuolar protein 8
zf-C3H2C3 (PF17122, IPR001841): Zinc-finger
zf-RING_11 (PF17123, IPR001841): RING-like zinc finger
109 WWP2interactor70.6678.459WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
110 XPO1interactor300.499359.112CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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