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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)104
The number (and %) of the onco-proteins45 (43.27 %)
The number (and %) of the tumor suppressors21 (20.19 %)
Total number of binary PPIs (saturation %)599 (11.18 %)
The number (and %) of affected PPIs106 (17.70 %)
The number of possible different fusions29
PPI diameter4
PPI radius2
The average degree of PPI10.635
Assortativity coefficient-0.2002
The network average Clustering coefficient0.416
The number (and %) of a zero Clustering coefficients16 (15.38 %)
The number (and %) of a zero Betweenness Centrality20 (19.23 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: BCR,FGFR1 All fusions
: AB742171; AJ298917; AJ298916; AB742170;
Proteins found in more fusions AP2M1 (see 3 fusions); BCR/ABL1 (see 182 fusions); GRK5 (see 3 fusions); GAB2 (see 3 fusions); HSP90AA1 (see 2 fusions); CBL (see 1 fusions); CTPS2 (see 1 fusions); JAK2 (see 3 fusions); KPNB1 (see 2 fusions); FRS3 (see 1 fusions); GRB2 (see 1 fusions); RAC1 (see 1 fusions); MYC (see 1 fusions); ERBB3 (see 2 fusions); CREBBP (see 5 fusions); STAT3 (see 2 fusions); CDH1 (see 3 fusions); ERBIN (see 4 fusions); PIK3R1 (see 1 fusions); STUB1 (see 1 fusions); SHC1 (see 1 fusions); RAC1/PKM (see 1 fusions); UBC (see 1 fusions); FGFR1 (see 1 fusions); NEDD4 (see 1 fusions); TP53 (see 3 fusions); HSPA8/HSPD1 (see 1 fusions); CDK9 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BCRparental protein560.1452550.022Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain
C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
IQ_SEC7_PH (PF16453, IPR001849): PH domain
2 FGFR1parental protein500.0633252.761I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
3 ABL1oncoprotein350.337272.360Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
4 AFDNoncoprotein31.0000DIL (PF01843, IPR018444, SM01132): DIL domain
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
FHA (PF00498, IPR000253, SM00240): FHA domain
MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Pap_E4 (PF02711, IPR003861): E4 protein
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
ARGLU (PF15346): Arginine and glutamate-rich 1
5 AP2M1protein found in more fusions110.64412.494Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
6 BNIP2interactor4019.628BNIP2 (PF12496, IPR022181): Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
CRAL_TRIO_2 (PF13716, IPR001251): Divergent CRAL/TRIO domain
7 CBLsuppressor360.272504.943Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
8 CCDC183interactor100MRP-63 (PF14978, IPR016576): Mitochondrial ribosome protein 63
9 CDC20oncoprotein90.17992.547WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
10 CDC42oncoprotein120.255106.414Ras (PF00071, IPR001806, SM00173): Ras family
11 CDH1suppressor110.33358.747Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
12 CDK9protein found in more fusions80.47643.677Pkinase (PF00069, IPR000719): Protein kinase domain
13 CEACAM21interactor21.0000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
14 CEP128interactor70.42915.028DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
15 CFTRsuppressor150.31993.759ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
16 CREBBPsuppressor140.256127.205Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
17 CRKoncoprotein240.409256.951SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
18 CRKLoncoprotein160.56740.841SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
19 CSNK2A2interactor90.306141.694Pkinase (PF00069, IPR000719): Protein kinase domain
20 CTNNB1oncoprotein140.319101.832Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
21 CTPS2protein found in more fusions40.33311.856CTP_synth_N (PF06418, IPR017456): CTP synthase N-terminus
GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
22 DLK1suppressor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
23 DOK1suppressor170.45066.959IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
24 ERBB3oncoprotein200.43384.373Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
25 ERBINoncoprotein80.5248.141LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
26 ERCC3oncoprotein40.8330.551ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
DUF2748 (PF10871, IPR020183): Protein of unknown function (DUF2748)
Helicase_C_3 (PF13625, IPR032830): Helicase conserved C-terminal domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
ERCC3_RAD25_C (PF16203, IPR032438): ERCC3/RAD25/XPB C-terminal helicase
27 EVI2Ainteractor100EVI2A (PF05399, IPR008608): Ectropic viral integration site 2A protein (EVI2A)
28 FDPSinteractor40.33315.341polyprenyl_synt (PF00348, IPR000092): Polyprenyl synthetase
29 FESoncoprotein80.33312.656FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Remorin_C (PF03763, IPR005516): Remorin, C-terminal region
SH2 (PF00017, IPR000980, SM00252): SH2 domain
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
30 FGF1oncoprotein308.894FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
31 FGF2oncoprotein208.894FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
32 FGF23interactor100FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
33 FGF8oncoprotein100FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
TraC_F_IV (PF11130, IPR025955): F pilus assembly Type-IV secretion system for plasmid transfer
34 FRS2interactor60.7337.720IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
35 FRS3suppressor50.50012.481IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
36 GAB2oncoprotein150.49527.297PH (PF00169, IPR001849, SM00233): PH domain
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
37 GABRR1interactor200Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
38 GINM1interactor21.0000NA
39 GOLGA7Binteractor100Serglycin (PF04360, IPR007455): Serglycin
Erf4 (PF10256, IPR019383): Golgin subfamily A member 7/ERF4 family
40 GRB14interactor30.6675.967BPS (PF08947, IPR015042): BPS (Between PH and SH2)
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
41 GRB2oncoprotein380.317368.103SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
42 GRK5protein found in more fusions50.5003.814Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
43 HCKoncoprotein130.321159.335Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
44 HEPACAM2interactor30.3336.671V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
PgaD (PF13994, IPR023829): PgaD-like protein
45 HIF1Asuppressor150.39053.304Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
46 HOXA9oncoprotein30.6673.443Hox9_act (PF04617, IPR006711): Hox9 activation region
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
47 HSP90AA1oncoprotein330.248647.484HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
48 HSPA4interactor130.55124.674Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
49 HSPA8oncoprotein250.377160.770HSP70 (PF00012, IPR013126): Hsp70 protein
50 HSPD1suppressor130.46239.640Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
51 IGSF21interactor100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
52 IL20RBinteractor100Interfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
Tissue_fac (PF01108, IPR003961): Tissue factor
53 IL3oncoprotein100IL3 (PF02059, IPR002183): Interleukin-3
54 INPP5Dinteractor110.67310.516Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
SH2 (PF00017, IPR000980, SM00252): SH2 domain
55 ITKoncoprotein90.67910.409BTK (PF00779, IPR001562, SM00107): BTK motif
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
56 JAK2oncoprotein160.43878.802FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
57 KIToncoprotein140.53867.841ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
58 KPNB1protein found in more fusions100.16779.111Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
59 LDLRAD4interactor30.6670.374Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
DUF2615 (PF11027, IPR020309): Protein of unknown function (DUF2615)
60 LGALS8interactor100Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
61 LNX1interactor60.6009.240PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
62 LRRK1interactor90.6078.691Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
63 LTBRoncoprotein31.0000Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family
64 MREGinteractor100MREG (PF15812, IPR031638): Melanoregulin
65 MYConcoprotein170.308123.685HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
66 NCAM1interactor30.6673.139fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Syndecan (PF01034, IPR027789): Syndecan domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
67 NCK1oncoprotein120.48557.607SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
68 NEDD4suppressor140.205159.367Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
69 NINLinteractor50.5008.235PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat
TBCA (PF02970, IPR004226): Tubulin binding cofactor A
DUF2389 (PF09493, IPR012663): Tryptophan-rich protein (DUF2389)
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
FAM184 (PF15665): Family with sequence similarity 184, A and B
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
70 NTRK1oncoprotein350.241559.035I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
71 PIK3CGoncoprotein21.0000Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3244 (PF11589, IPR021638): Domain of unknown function (DUF3244)
DUF4135 (PF13575, IPR025410): Domain of unknown function (DUF4135)
72 PIK3R1oncoprotein270.406192.910RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
73 PIK3R2oncoprotein160.542106.398RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
74 PKMoncoprotein60.26734.395PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
75 PLCG1oncoprotein190.380169.240C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
76 PPP2R1Bsuppressor50.5007.074HEAT (PF02985, IPR000357): HEAT repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_2 (PF13646): HEAT repeats
77 PTGES3interactor80.6672.640CS (PF04969, IPR007052): CS domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
78 PTK6interactor50.5004.988Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
79 PTPN6suppressor100.64411.154SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus
80 PXNoncoprotein90.6399.601LIM (PF00412, IPR001781, SM00132): LIM domain
Paxillin (PF03535): Paxillin family
81 RAC1oncoprotein80.14326.540Ras (PF00071, IPR001806, SM00173): Ras family
82 RB1suppressor90.52814.847RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
83 RHOAsuppressor40.16732.603Ras (PF00071, IPR001806, SM00173): Ras family
84 RPS6KA3interactor60.4679.400Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
85 RSPH9interactor100Radial_spoke (PF04712, IPR006802): Radial spokehead-like protein
86 SEC13interactor31.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
87 SHBinteractor80.7866.097Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
SH2 (PF00017, IPR000980, SM00252): SH2 domain
Period_C (PF12114, IPR022728): Period protein 2/3C-terminal region
88 SHC1oncoprotein240.49072.759PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
89 SOS1oncoprotein150.571130.303Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
PH (PF00169, IPR001849, SM00233): PH domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
90 SRConcoprotein280.311333.917Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
91 STAT3suppressor180.272166.527SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
92 STUB1suppressor140.61515.141U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
93 TGFBR2suppressor70.42922.270ecTbetaR2 (PF08917, IPR015013): Transforming growth factor beta receptor 2 ectodomain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
94 TNFRSF10Bsuppressor70.19089.366Death (PF00531, IPR000488, SM00005): Death domain
RskA (PF10099, IPR018764): Anti-sigma-K factor rskA
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
95 TP53suppressor230.277192.563DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
96 TSG101suppressor90.53616.068APG6 (PF04111, IPR007243): Autophagy protein Apg6
Laminin_II (PF06009, IPR010307): Laminin Domain II
UEV (PF05743, IPR008883): UEV domain
Vps23_core (PF09454, IPR017916): Vps23 core domain
97 TSPAN3interactor21.0000Hum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein
Tetraspannin (PF00335, IPR018499): Tetraspanin family
98 UBASH3Binteractor120.7279.080His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily
SH3_9 (PF14604, IPR001452): Variant SH3 domain
99 UBCprotein found in more fusions230.312185.296ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
100 UNC119interactor30.6670.917GMP_PDE_delta (PF05351, IPR008015): GMP-PDE, delta subunit
101 VAV1oncoprotein130.47466.566PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
102 VPS28interactor40.8330.200VPS28 (PF03997, IPR007143): VPS28 protein
103 WDR48suppressor50.8001.114WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF3337 (PF11816, IPR021772): Domain of unknown function (DUF3337)
104 XPO1interactor210.257236.701CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 BCRparental proteinBcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain
C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
IQ_SEC7_PH (PF16453, IPR001849): PH domain
AB742170, AB742171, AJ298916, AJ298917
2 EVI2AinteractorEVI2A (PF05399, IPR008608): Ectropic viral integration site 2A protein (EVI2A)AB742170, AJ298916
3 FDPSinteractorpolyprenyl_synt (PF00348, IPR000092): Polyprenyl synthetaseAB742170, AB742171, AJ298916, AJ298917
4 FGF1oncoproteinFGF (PF00167, IPR002209, SM00442): Fibroblast growth factorAB742170, AJ298916
5 FGF2oncoproteinFGF (PF00167, IPR002209, SM00442): Fibroblast growth factorAB742170, AJ298916
6 FGF23interactorFGF (PF00167, IPR002209, SM00442): Fibroblast growth factorAB742170, AJ298916
7 FGFR1parental proteinI-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
AB742170, AB742171, AJ298916, AJ298917
8 GINM1interactorNAAB742170, AB742171, AJ298916, AJ298917
9 HEPACAM2interactorV-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
PgaD (PF13994, IPR023829): PgaD-like protein
AB742170, AJ298916
10 LDLRAD4interactorLdl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
DUF2615 (PF11027, IPR020309): Protein of unknown function (DUF2615)
AB742170, AJ298916
11 LGALS8interactorGal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectinAB742170, AJ298916
12 MREGinteractorMREG (PF15812, IPR031638): MelanoregulinAB742170, AJ298916

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